FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070000009> ?p ?o ?g. }

• W2070000009 endingPage "892" @default.
• W2070000009 startingPage "889" @default.
• W2070000009 abstract "Abstract As glucuronidation is a major process for the metabolism and removal of lipophilic chemicals, polymorphic variations in genes encoding the enzymes involved in this process, the UDP glucuronosyltransferases (UGT), may have a significant impact on our capacity to detoxify and eliminate drugs and toxins. Although 24 human UGT genes have been identified to date, only polymorphisms in five UGTs, viz. UGT1A1, UGT1A6, UGT2B4, UGT2B7 and UGT2B15 have been described. Polymorphisms in UGT1A1, the major bilirubin-glucuronidating form, often result in a decreased capacity to glucuronidate bilirubin, such as observed in Gilbert Syndrome and some forms of perinatal jaundice. The frequencies of individual UGT1A1 polymorphisms show extensive variability across ethnic groups. Two variants of UGT1A6 and UGT2B4 and one variant of UGT2B7 and UGT2B15 have been identified. However, the clinical significance of these variants is unclear. More UGT polymorphisms will undoubtedly be discovered when the human genome is sequenced. However, unless the UGT in question is responsible for the exclusive metabolism of a particular drug or chemical ( e.g. UGT1A1 and bilirubin) or is the predominant or only UGT present in the cell, it is unlikely that these polymorphisms will be of major clinical significance." @default.
• W2070000009 created "2016-06-24" @default.
• W2070000009 creator A5008901409 @default.
• W2070000009 creator A5055670639 @default.
• W2070000009 creator A5076781787 @default.
• W2070000009 date "2000-09-18" @default.
• W2070000009 modified "2023-10-18" @default.
• W2070000009 title "Polymorphisms in UDP Glucuronosyltransferase Genes: Functional Consequences and Clinical Relevance" @default.
• W2070000009 cites W144444663 @default.
• W2070000009 cites W1509233017 @default.
• W2070000009 cites W1875161015 @default.
• W2070000009 cites W1967282710 @default.
• W2070000009 cites W1989012950 @default.
• W2070000009 cites W1995727180 @default.
• W2070000009 cites W2006478647 @default.
• W2070000009 cites W2016335393 @default.
• W2070000009 cites W2016527473 @default.
• W2070000009 cites W2026270269 @default.
• W2070000009 cites W2030868542 @default.
• W2070000009 cites W2041675615 @default.
• W2070000009 cites W2043189587 @default.
• W2070000009 cites W2048327703 @default.
• W2070000009 cites W2049820137 @default.
• W2070000009 cites W2058859278 @default.
• W2070000009 cites W2061639233 @default.
• W2070000009 cites W2089720722 @default.
• W2070000009 cites W2107262592 @default.
• W2070000009 cites W2137613776 @default.
• W2070000009 cites W2161069288 @default.
• W2070000009 cites W2168212144 @default.
• W2070000009 cites W2322536880 @default.
• W2070000009 cites W4234585565 @default.
• W2070000009 doi "https://doi.org/10.1515/cclm.2000.129" @default.
• W2070000009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11097345" @default.
• W2070000009 hasPublicationYear "2000" @default.
• W2070000009 type Work @default.
• W2070000009 sameAs 2070000009 @default.
• W2070000009 citedByCount "98" @default.
• W2070000009 countsByYear W20700000092012 @default.
• W2070000009 countsByYear W20700000092013 @default.
• W2070000009 countsByYear W20700000092014 @default.
• W2070000009 countsByYear W20700000092015 @default.
• W2070000009 countsByYear W20700000092016 @default.
• W2070000009 countsByYear W20700000092017 @default.
• W2070000009 countsByYear W20700000092018 @default.
• W2070000009 countsByYear W20700000092019 @default.
• W2070000009 countsByYear W20700000092020 @default.
• W2070000009 countsByYear W20700000092021 @default.
• W2070000009 countsByYear W20700000092022 @default.
• W2070000009 countsByYear W20700000092023 @default.
• W2070000009 crossrefType "journal-article" @default.
• W2070000009 hasAuthorship W2070000009A5008901409 @default.
• W2070000009 hasAuthorship W2070000009A5055670639 @default.
• W2070000009 hasAuthorship W2070000009A5076781787 @default.
• W2070000009 hasConcept C104317684 @default.
• W2070000009 hasConcept C126322002 @default.
• W2070000009 hasConcept C149737253 @default.
• W2070000009 hasConcept C180754005 @default.
• W2070000009 hasConcept C181199279 @default.
• W2070000009 hasConcept C2777469378 @default.
• W2070000009 hasConcept C2779907587 @default.
• W2070000009 hasConcept C2781278898 @default.
• W2070000009 hasConcept C54355233 @default.
• W2070000009 hasConcept C55493867 @default.
• W2070000009 hasConcept C62231903 @default.
• W2070000009 hasConcept C63363279 @default.
• W2070000009 hasConcept C71924100 @default.
• W2070000009 hasConcept C86803240 @default.
• W2070000009 hasConcept C87644729 @default.
• W2070000009 hasConcept C89311334 @default.
• W2070000009 hasConceptScore W2070000009C104317684 @default.
• W2070000009 hasConceptScore W2070000009C126322002 @default.
• W2070000009 hasConceptScore W2070000009C149737253 @default.
• W2070000009 hasConceptScore W2070000009C180754005 @default.
• W2070000009 hasConceptScore W2070000009C181199279 @default.
• W2070000009 hasConceptScore W2070000009C2777469378 @default.
• W2070000009 hasConceptScore W2070000009C2779907587 @default.
• W2070000009 hasConceptScore W2070000009C2781278898 @default.
• W2070000009 hasConceptScore W2070000009C54355233 @default.
• W2070000009 hasConceptScore W2070000009C55493867 @default.
• W2070000009 hasConceptScore W2070000009C62231903 @default.
• W2070000009 hasConceptScore W2070000009C63363279 @default.
• W2070000009 hasConceptScore W2070000009C71924100 @default.
• W2070000009 hasConceptScore W2070000009C86803240 @default.
• W2070000009 hasConceptScore W2070000009C87644729 @default.
• W2070000009 hasConceptScore W2070000009C89311334 @default.
• W2070000009 hasIssue "9" @default.
• W2070000009 hasLocation W20700000091 @default.
• W2070000009 hasLocation W20700000092 @default.
• W2070000009 hasOpenAccess W2070000009 @default.
• W2070000009 hasPrimaryLocation W20700000091 @default.
• W2070000009 hasRelatedWork W1974120186 @default.
• W2070000009 hasRelatedWork W1991523976 @default.
• W2070000009 hasRelatedWork W2003537469 @default.
• W2070000009 hasRelatedWork W2070000009 @default.
• W2070000009 hasRelatedWork W2093652475 @default.
• W2070000009 hasRelatedWork W2105026769 @default.
• W2070000009 hasRelatedWork W2110507385 @default.

• next