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• W2070003669 abstract "The values of bone mineral density (BMD) were compared in postmenopausal women with and without breast cancer. A cross-sectional study was conducted, including 51 breast cancer survivors (BCS) and 71 women without breast cancer, who were non-users of hormone therapy, tamoxifen, or aromatase inhibitors. BMD T-scores and measurements in grams per centimeter squared (g/cm2) were obtained at the femoral neck, trochanter, Ward's triangle, and lumbar spine. Osteopenia and osteoporosis were grouped and categorized as abnormal BMD. Unconditional logistic regression analysis was used to estimate the odds ratios (OR) of abnormal BMD values as measures of association, with 95% confidence intervals (CIs), adjusting for age, years since menopause, parity, and body mass index (BMI). The mean age of the women with and without breast cancer was 54.7 ± 5.8 years and 58.2 ± 4.8 years (p < 0.01), respectively. After adjusting for age, parity and BMI, abnormal BMD at the femoral neck (adjusted OR: 4.8; 95% CI: 1.5–15.4), trochanter (adjusted OR: 4.6; 95% CI: 1.4–15.5), and Ward's triangle (adjusted OR: 4.5; 95% CI: 1.5–12.9) were significantly more frequent in postmenopausal BCS than in women without breast cancer. Postmenopausal BCS had a significantly lower mean BMD at the trochanter (0.719 vs. 0.809 g/cm2, p < 0.01) and at the Ward's triangle (0.751 vs. 0.805 g/cm2, p = 0.03). The prevalence of abnormal BMD was higher in postmenopausal BCS than in postmenopausal women without breast cancer. Bone health requires special vigilance and the adoption of interventions should be instituted early to minimize bone loss in BCS. Comparar a densidade mineral óssea (DMO) de mulheres na pós-menopausa com e sem câncer de mama. Conduziu-se estudo de corte transversal, incluindo 51 mulheres com câncer de mama e 71 mulheres sem câncer de mama, não usuárias de terapia hormonal, tamoxifeno ou de inibidores da aromatase. Avaliou-se a DMO, em T-score e em gramas por centímetro quadrado (g/cm2), no colo do fêmur, trocânter, triângulo de Wards e na coluna lombar. Osteopenia e osteoporose foram agrupadas e categorizadas como DMO alterada. Utilizou-se a análise de regressão logística não condicional para estimar o odds ratios (OR) de DMO alterada como medida de associação, com intervalo de confiança de 95% (IC 95%), ajustando-se por idade, anos de menopausa, paridade e índice de massa corpórea (IMC). A média de idade de mulheres com e sem câncer de mama foi 54,7 ± 5,8 anos e 58,2 ± 4,8 anos (p < 0,01), respectivamente. Após ajustar por idade, paridade e IMC, DMO alterada no colo do fêmur (OR ajustado: 4,8; IC 95%: 1,5–15,4), trocânter (OR ajustado: 4,6; IC 95%: 1,4–15,5) e no triângulo de Wards (OR ajustado: 4,5; IC 95%: 1,5–12,9) foi mais frequente em mulheres com câncer de mama. Mulheres com câncer de mama apresentaram significativamente menor média de DMO no trocânter (0,719 vs. 0,809 g/cm2, p < 0,01) e no triângulo de Wards (0,751 vs. 0,805 g/cm2, p = 0,03). A prevalência de DMO alterada foi maior em mulheres na pós-menopausa com câncer de mama. A saúde óssea requer vigilância especial e a adoção precoce de intervenções para minimizar a perda óssea de mulheres com câncer de mama." @default.
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• W2070003669 date "2012-11-01" @default.
• W2070003669 modified "2023-09-30" @default.
• W2070003669 title "Bone mineral density in postmenopausal women with and without breast cancer" @default.
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• W2070003669 doi "https://doi.org/10.1590/s0104-42302012000600011" @default.
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