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- W2070009178 abstract "El objetivo de este estudio de corte transversal fue comparar la prevalencia de lesión de órganos diana (LOD) y de enfermedad cardiovascular (ECV) establecida en una cohorte de pacientes hipertensos no diabéticos con 3 o más factores de riesgo cardiovascular (FRCV) frente a un grupo de hipertensos diabéticos tipo 2. Se incluyeron 4.725 pacientes, 62% varones, con una edad media (DE) de 64 (12) años, hipertensos diabéticos tipo 2, independientemente del número de FRCV asociados (N = 2.608), o no diabéticos, en cuyo caso se requería la presencia de 3 FRCV (N = 2.117). Se determinó la prevalencia de ECV establecida (interrogatorio clínico) y de LOD (hipertrofia ventricular izquierda por electrocardiografía, microalbuminuria y filtrado glomerular estimado). Los pacientes hipertensos diabéticos tipo 2 presentaban una mayor edad y obesidad más marcada. Asimismo, dichos pacientes mostraban mayores prevalencias de microalbuminuria y macroalbuminuria, insuficiencia renal, hipertrofia ventricular izquierda, placas de ateroma en arterias carótidas y ECV en comparación con los hipertensos no diabéticos con 3 o más FRCV. El análisis multivariante mostraba que el riesgo de presentar LOD o ECV previa se relacionaba de forma independiente con la presencia de diabetes. Los pacientes hipertensos diabéticos tipo 2 presentan una mayor prevalencia de LOD y de ECV respecto a los pacientes hipertensos no diabéticos con 3 o más FRCV. Aunque ambas situaciones se incluyen en el estrato de riesgo cardiovascular elevado, cabe esperar que los hipertensos diabéticos tengan una mayor incidencia de complicaciones cardiovasculares. The aim of this cross-sectional study was to compare the prevalence of target organ damage (TOD) and established cardiovascular disease (CVD) in a cohort of nondiabetic hypertensive patients with 3 or more cardiovascular risk factors (CVRF) against a group of hypertensives with type 2 diabetes. We included 4,725 hypertensive patients, 62% male, mean age 64 (SD 12) years, with type 2 diabetes mellitus, independently of the number of associated CVRF (N = 2,608), or non-diabetics, in which case we required the presence of 3 CVRF (N = 2,117). The prevalence of established CVD (clinical interview) and TOD (left ventricular hypertrophy by electrocardiogram, microalbuminuria and estimated glomerular filtration rate) were estimated. Hypertensive patients with type 2 diabetes had an older age and more marked obesity. Furthermore, these patients showed a higher prevalence of micro- and macroalbuminuria, renal failure, left ventricular hypertrophy, atherosclerotic plaques in carotid arteries and CVD compared with nondiabetic hypertensive patients with 3 or more CVRF. Multivariate analysis showed that the risk of TOD or established CVD were associated independently with the presence of diabetes. Hypertensive patients with type 2 diabetes have a higher prevalence of LOD and CVD compared to nondiabetic hypertensive patients with 3 or more CVRF. Although both situations are included in the high cardiovascular risk stratum, it would be expected an increased incidence of cardiovascular complications in hypertensive diabetic patients." @default.
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- W2070009178 date "2013-10-01" @default.
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- W2070009178 title "Influencia de la diabetes sobre la prevalencia de lesión de órganos diana y enfermedad cardiovascular en los pacientes hipertensos de alto riesgo" @default.
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- W2070009178 doi "https://doi.org/10.1016/j.medcli.2012.05.032" @default.
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