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• W2070010006 abstract "Using evidence from randomized trials, systematic reviews and meta-analyses only, the following conclusions can be drawn regarding intrauterine insemination (IUI) for male subfertility: Compared with timed intercourse, IUI significantly increases the probability of conception [Peto OR with 95% CIs: 3.1 (1.5–6.3)]. Mild ovarian hyperstimulation does not increase pregnancy rates, except for couples with a mild semen factor [Peto OR with 95% CIs: 1.4 (0.86–2.4)]. In cases where mild ovarian hyperstimulation (MOH) is applied, gonadotropins seem to be more effective compared with clomiphene citrate [Peto OR with 95% CIs: 2.2 (1.2–3.9)]. Prevention of multiplets is a major issue when applying MOH. A strategy to prevent multiple pregnancies is proposed. Only a few randomized trials exist that compare the cost-effectiveness of MOH/IUI with IVF-ET and/or ICSI. From the available evidence, it can be concluded that IUI is the most cost-effective treatment option when multiple pregnancies are prevented. There is no difference in treatment outcome after IUI between gradient techniques and swim-up for semen preparation [Peto OR with 95% CIs: 0.55 (0.17–1.76)]. Up till now it has been impossible to predict treatment outcome on an individual basis. The post-wash total motile count is a good predictor of non-pregnancy. The optimal cut-off level is between 0.8 and 5 million. Below these levels, ICSI should be considered the treatment option of first choice." @default.
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• W2070010006 creator A5064864190 @default.
• W2070010006 date "2004-04-01" @default.
• W2070010006 modified "2023-09-26" @default.
• W2070010006 title "Intrauterine insemination for idiopathic male subfertility" @default.
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• W2070010006 doi "https://doi.org/10.1016/j.ics.2004.02.005" @default.
• W2070010006 hasPublicationYear "2004" @default.
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