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- W2070011703 abstract "La connaissance de la physiologie de la vitamine D a considérablement progressé, la faisant passer du rôle d’hormone à tropisme purement phosphocalcique et osseux à celui d’hormone jouant un rôle global sur la santé (anti-infectieux, anti-inflammatoire, antitumoral et protecteur cardiovasculaire). En parallèle à cette description d’effets pléiotropes à la fois dans des modèles cellulaires, des modèles animaux et des études cliniques, de plus en plus d’études épidémiologiques ont montré l’importance de la carence en vitamine D dans la population générale. Nous proposons une revue de la littérature, en l’illustrant de données lyonnaises sur le statut vitaminique D d’une population pédiatrique. À la lumière de ces nouvelles données physiopathologiques d’une part et au vu de la proportion d’enfants français semblant souffrir de déficit en vitamine D d’autre part, il apparaît urgent de réfléchir à une actualisation des recommandations actuelles de supplémentation systématique en vitamine D et de surveiller régulièrement les concentrations sériques de vitamine D chez les enfants souffrant de pathologies chroniques, d’autant plus qu’ils sont à risque de poussées inflammatoires, de complications osseuses, cardiovasculaires ou infectieuses. There is a recent renewed interest in vitamin D metabolism and pathophysiology, due to its recent description as a hormone with a positive impact on global health rather than a strictly bone hormone: vitamin D could be a protective factor against infection, autoimmunity, cardiovascular morbidity, and cancer. By contrast, vitamin D deficiency appears to be increasingly frequent worldwide. We propose a review of these new aspects of vitamin D metabolism, with a focus on vitamin D status in a local pediatric cohort. There is an urgent need for revisiting current guidelines on vitamin D supplementation and for closely monitoring serum vitamin D in children with chronic diseases, i.e., at greater risk of cardiovascular impairment, bone morbidity, infectious disease, and acute inflammation." @default.
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- W2070011703 date "2010-12-01" @default.
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- W2070011703 title "Vitamine D : un acteur majeur en santé ?" @default.
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- W2070011703 doi "https://doi.org/10.1016/j.arcped.2010.09.003" @default.
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