Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070016469> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2070016469 endingPage "314" @default.
- W2070016469 startingPage "293" @default.
- W2070016469 abstract "The advent of magnetic resonance imaging (MRI) and spectroscopy (MRS) and of single photon and positron emission tomography (SPET:PET) has allowed acquisition of data, not otherwise available, on cerebral metabolic function in patients with hepatic encephalopathy. Hyperintensity of the globus pallidus has been observed in cerebral T1-weighted MR images in patients with sub-clinical or overt hepatic encephalopathy, most likely due to the deposition of manganese; these trace metal deposits reflect either intoxication or the presence of an adaptive process leading to improved efficacy of ammonia detoxification by astrocytes. Cerebral 31P MRS has shown that there is no primary deficit in energy metabolism in patients with hepatic encephalopathy, but rather an impairment of phospholipid membrane metabolism; cerebral 1H MRS shows a characteristic pattern of abnormalities in these patients, namely, a significant increase in glutamine/glutamate and significant reductions in choline-containing compounds associated with phospholipid membrane metabolism and of myo-inositol which functions, in part, as an organic osmolyte. SPET and PET technology have not been adequately exploited in the study of hepatic encephalopathy to date; the few studies available have produced conflicting results, most likely because little or no account was taken of the effects of chronic liver disease, portal-systemic shunting or enhanced blood-brain barrier permeability on tracer-ligand availability. All of these techniques need to be further exploited in well-characterized populations with, wherever possible, standardization of techniques between centers; the factors likely to affect tracer-ligand availability must be adequately controlled to allow correct interpretation of the data obtained." @default.
- W2070016469 created "2016-06-24" @default.
- W2070016469 creator A5069623980 @default.
- W2070016469 date "1996-01-01" @default.
- W2070016469 modified "2023-10-04" @default.
- W2070016469 title "Noninvasive Neuroinvestigation in Liver Disease" @default.
- W2070016469 doi "https://doi.org/10.1055/s-2007-1007242" @default.
- W2070016469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8989815" @default.
- W2070016469 hasPublicationYear "1996" @default.
- W2070016469 type Work @default.
- W2070016469 sameAs 2070016469 @default.
- W2070016469 citedByCount "33" @default.
- W2070016469 countsByYear W20700164692012 @default.
- W2070016469 countsByYear W20700164692014 @default.
- W2070016469 countsByYear W20700164692015 @default.
- W2070016469 countsByYear W20700164692016 @default.
- W2070016469 countsByYear W20700164692019 @default.
- W2070016469 crossrefType "journal-article" @default.
- W2070016469 hasAuthorship W2070016469A5069623980 @default.
- W2070016469 hasConcept C126322002 @default.
- W2070016469 hasConcept C126838900 @default.
- W2070016469 hasConcept C142724271 @default.
- W2070016469 hasConcept C143409427 @default.
- W2070016469 hasConcept C146638467 @default.
- W2070016469 hasConcept C2775842073 @default.
- W2070016469 hasConcept C2777075537 @default.
- W2070016469 hasConcept C2777214474 @default.
- W2070016469 hasConcept C2778621155 @default.
- W2070016469 hasConcept C2779102576 @default.
- W2070016469 hasConcept C2780325230 @default.
- W2070016469 hasConcept C2781123555 @default.
- W2070016469 hasConcept C2989005 @default.
- W2070016469 hasConcept C71924100 @default.
- W2070016469 hasConceptScore W2070016469C126322002 @default.
- W2070016469 hasConceptScore W2070016469C126838900 @default.
- W2070016469 hasConceptScore W2070016469C142724271 @default.
- W2070016469 hasConceptScore W2070016469C143409427 @default.
- W2070016469 hasConceptScore W2070016469C146638467 @default.
- W2070016469 hasConceptScore W2070016469C2775842073 @default.
- W2070016469 hasConceptScore W2070016469C2777075537 @default.
- W2070016469 hasConceptScore W2070016469C2777214474 @default.
- W2070016469 hasConceptScore W2070016469C2778621155 @default.
- W2070016469 hasConceptScore W2070016469C2779102576 @default.
- W2070016469 hasConceptScore W2070016469C2780325230 @default.
- W2070016469 hasConceptScore W2070016469C2781123555 @default.
- W2070016469 hasConceptScore W2070016469C2989005 @default.
- W2070016469 hasConceptScore W2070016469C71924100 @default.
- W2070016469 hasIssue "03" @default.
- W2070016469 hasLocation W20700164691 @default.
- W2070016469 hasLocation W20700164692 @default.
- W2070016469 hasOpenAccess W2070016469 @default.
- W2070016469 hasPrimaryLocation W20700164691 @default.
- W2070016469 hasRelatedWork W1510544982 @default.
- W2070016469 hasRelatedWork W2122572820 @default.
- W2070016469 hasRelatedWork W2774144274 @default.
- W2070016469 hasRelatedWork W2777786092 @default.
- W2070016469 hasRelatedWork W2905028812 @default.
- W2070016469 hasRelatedWork W2955727009 @default.
- W2070016469 hasRelatedWork W3030351087 @default.
- W2070016469 hasRelatedWork W3128176530 @default.
- W2070016469 hasRelatedWork W4251345870 @default.
- W2070016469 hasRelatedWork W2946539037 @default.
- W2070016469 hasVolume "16" @default.
- W2070016469 isParatext "false" @default.
- W2070016469 isRetracted "false" @default.
- W2070016469 magId "2070016469" @default.
- W2070016469 workType "article" @default.