FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070017821> ?p ?o ?g. }

• W2070017821 endingPage "159" @default.
• W2070017821 startingPage "158" @default.
• W2070017821 abstract "To the Editor:We read with interest the article by Lee et al.1.Lee S.K. Lo W. Memeo L. Rotterdam H. Green P.H.R. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet.Gastrointest Endosc. 2003; 57: 187-191Abstract Full Text PDF PubMed Scopus (185) Google Scholar on the persistence of mucosal damage in patients with celiac disease who maintained a gluten-free diet. They concluded that some degree of villous atrophy is the rule and not the exception, even in patients treated long-term. Based on our data, we have a more optimistic view.Our routine has been to take small intestinal biopsy specimens at 6 and, recently, at 12 months after the institution of a gluten-free diet. In addition, a number of specimens have been taken from patients treated long-term for celiac disease while they participated in various follow-up studies.2.Kaukinen K. Collin P. Holm K. Rantala I. Vuolteenaho N. Reunala T. Maki M. Wheat starch-containing gluten-free flour products in the treatment of coeliac disease and dermatitis herpetiformis. A long-term follow-up study.Scand J Gastroenterol. 1999; 34: 164-169Google Scholar, 3.Kaukinen K. Sulkanen S. Maki M. Collin P. IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease.Eur J Gastroenterol Hepatol. 2002; 14: 311-315Crossref PubMed Scopus (125) Google Scholar These patients represent well our population of patients with celiac disease, which includes more than 800 adults. As shown in the figure, the mucosal morphology in patients treated with a gluten-free diet for an average of 8 years was similar to that in our nonceliac control subjects. Only 3 (4%) of 65 patients with celiac disease had partial atrophy and none had subtotal villous atrophy. By comparison, after 6 to 12 months of dietary therapy, 43% had normal, 47% partial, and 10% subtotal villous atrophy, although intraepithelial lymphocytosis was not present. Of note, when dietary assessment revealed occasional transgressions, the mucosal damage was persistent in most cases, as has also been shown by others.4.Ciacci C. Maurelli L. Klain M. Savino G. Salvatore M. Mazzacca G. et al.Effects of dietary treatment on bone mineral density in adults with celiac disease: factors predicting response.Am J Gastroenterol. 1997; 92: 992-996PubMed Google ScholarOne reason for the discrepancy might be that Lee et al.1.Lee S.K. Lo W. Memeo L. Rotterdam H. Green P.H.R. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet.Gastrointest Endosc. 2003; 57: 187-191Abstract Full Text PDF PubMed Scopus (185) Google Scholar applied a relatively high crypt:villous ratio (1:4) as proof of complete recovery; this being even higher than the average ratio in our nonceliac control subjects. The decision as to where the villous ends and the crypt begins is subjective.5.Corazza G.R. Frazzoni M. Dixon M.F. Gasbarrini G. Quantitative assessment of the mucosal architecture of jejunal biopsy specimens: a comparison between linear measurement, stereology, and computer aided microscopy.J Clin Pathol. 1985; 38: 765-770Crossref PubMed Scopus (47) Google Scholar However, histologic specimens were also evaluated blindly with no knowledge of the clinical diagnosis, and the average crypt:villous ratio in control subjects was comparable to that in previous studies.6.Kuitunen P. Kosnai I. Savilahti E. Morphometric study of the jejunal mucosa in various childhood enteropathies with special reference to intraepithelial lymphocytes.J Pediatr Gastroenterol Nutr. 1982; 1: 525-531Crossref PubMed Scopus (85) Google Scholar, 7.Roy-Choudhury D. Cooke W.T. Tan D.T. Banwell J.G. Smits B.J. Jejunal biopsy: criteria and significance.Scand J Gastroenterol. 1966; 1: 57-74PubMed Google Scholar In addition, the severity of the disease may originally have been different and, as Lee et al.1.Lee S.K. Lo W. Memeo L. Rotterdam H. Green P.H.R. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet.Gastrointest Endosc. 2003; 57: 187-191Abstract Full Text PDF PubMed Scopus (185) Google Scholar state, inadvertent gluten intake is difficult to identify. We agree that complete recovery of the celiac mucosa often requires longer than 12 months. On the other hand, persistent mucosal atrophy increases the risk of complications such as osteoporosis, even in asymptomatic patients.8.Valdimarsson T. Lofman O. Toss G. Strom M. Reversal of osteopenia with diet in adult coeliac disease.Gut. 1996; 38: 322-327Crossref PubMed Scopus (184) Google Scholar, 9.Walters J.R. Bone mineral density in coeliac disease.Gut. 1994; 35: 150-151Crossref PubMed Scopus (55) Google Scholar, 10.Cellier C. Flobert C. Cormier C. Roux C. Schmitz J. Severe osteopenia in symptom-free adults with a childhood diagnosis of coeliac disease.Lancet. 2000; 355: 806Abstract Full Text Full Text PDF PubMed Scopus (110) Google Scholar Therefore, in every case where significant villous atrophy is present, a thorough check-up, and especially a comprehensive dietary assessment, are essential.It should not be inferred that a normal villous architecture is unattainable in patients with celiac disease. A high percentage of clinically detected celiac cases, a wide selection of gluten-free products on the market, and the active role of lay societies devoted to celiac disease are of help in achieving this definitive goal, that is a good clinical and histopathologic response to a gluten-free diet. To the Editor: We read with interest the article by Lee et al.1.Lee S.K. Lo W. Memeo L. Rotterdam H. Green P.H.R. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet.Gastrointest Endosc. 2003; 57: 187-191Abstract Full Text PDF PubMed Scopus (185) Google Scholar on the persistence of mucosal damage in patients with celiac disease who maintained a gluten-free diet. They concluded that some degree of villous atrophy is the rule and not the exception, even in patients treated long-term. Based on our data, we have a more optimistic view. Our routine has been to take small intestinal biopsy specimens at 6 and, recently, at 12 months after the institution of a gluten-free diet. In addition, a number of specimens have been taken from patients treated long-term for celiac disease while they participated in various follow-up studies.2.Kaukinen K. Collin P. Holm K. Rantala I. Vuolteenaho N. Reunala T. Maki M. Wheat starch-containing gluten-free flour products in the treatment of coeliac disease and dermatitis herpetiformis. A long-term follow-up study.Scand J Gastroenterol. 1999; 34: 164-169Google Scholar, 3.Kaukinen K. Sulkanen S. Maki M. Collin P. IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease.Eur J Gastroenterol Hepatol. 2002; 14: 311-315Crossref PubMed Scopus (125) Google Scholar These patients represent well our population of patients with celiac disease, which includes more than 800 adults. As shown in the figure, the mucosal morphology in patients treated with a gluten-free diet for an average of 8 years was similar to that in our nonceliac control subjects. Only 3 (4%) of 65 patients with celiac disease had partial atrophy and none had subtotal villous atrophy. By comparison, after 6 to 12 months of dietary therapy, 43% had normal, 47% partial, and 10% subtotal villous atrophy, although intraepithelial lymphocytosis was not present. Of note, when dietary assessment revealed occasional transgressions, the mucosal damage was persistent in most cases, as has also been shown by others.4.Ciacci C. Maurelli L. Klain M. Savino G. Salvatore M. Mazzacca G. et al.Effects of dietary treatment on bone mineral density in adults with celiac disease: factors predicting response.Am J Gastroenterol. 1997; 92: 992-996PubMed Google Scholar One reason for the discrepancy might be that Lee et al.1.Lee S.K. Lo W. Memeo L. Rotterdam H. Green P.H.R. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet.Gastrointest Endosc. 2003; 57: 187-191Abstract Full Text PDF PubMed Scopus (185) Google Scholar applied a relatively high crypt:villous ratio (1:4) as proof of complete recovery; this being even higher than the average ratio in our nonceliac control subjects. The decision as to where the villous ends and the crypt begins is subjective.5.Corazza G.R. Frazzoni M. Dixon M.F. Gasbarrini G. Quantitative assessment of the mucosal architecture of jejunal biopsy specimens: a comparison between linear measurement, stereology, and computer aided microscopy.J Clin Pathol. 1985; 38: 765-770Crossref PubMed Scopus (47) Google Scholar However, histologic specimens were also evaluated blindly with no knowledge of the clinical diagnosis, and the average crypt:villous ratio in control subjects was comparable to that in previous studies.6.Kuitunen P. Kosnai I. Savilahti E. Morphometric study of the jejunal mucosa in various childhood enteropathies with special reference to intraepithelial lymphocytes.J Pediatr Gastroenterol Nutr. 1982; 1: 525-531Crossref PubMed Scopus (85) Google Scholar, 7.Roy-Choudhury D. Cooke W.T. Tan D.T. Banwell J.G. Smits B.J. Jejunal biopsy: criteria and significance.Scand J Gastroenterol. 1966; 1: 57-74PubMed Google Scholar In addition, the severity of the disease may originally have been different and, as Lee et al.1.Lee S.K. Lo W. Memeo L. Rotterdam H. Green P.H.R. Duodenal histology in patients with celiac disease after treatment with a gluten-free diet.Gastrointest Endosc. 2003; 57: 187-191Abstract Full Text PDF PubMed Scopus (185) Google Scholar state, inadvertent gluten intake is difficult to identify. We agree that complete recovery of the celiac mucosa often requires longer than 12 months. On the other hand, persistent mucosal atrophy increases the risk of complications such as osteoporosis, even in asymptomatic patients.8.Valdimarsson T. Lofman O. Toss G. Strom M. Reversal of osteopenia with diet in adult coeliac disease.Gut. 1996; 38: 322-327Crossref PubMed Scopus (184) Google Scholar, 9.Walters J.R. Bone mineral density in coeliac disease.Gut. 1994; 35: 150-151Crossref PubMed Scopus (55) Google Scholar, 10.Cellier C. Flobert C. Cormier C. Roux C. Schmitz J. Severe osteopenia in symptom-free adults with a childhood diagnosis of coeliac disease.Lancet. 2000; 355: 806Abstract Full Text Full Text PDF PubMed Scopus (110) Google Scholar Therefore, in every case where significant villous atrophy is present, a thorough check-up, and especially a comprehensive dietary assessment, are essential. It should not be inferred that a normal villous architecture is unattainable in patients with celiac disease. A high percentage of clinically detected celiac cases, a wide selection of gluten-free products on the market, and the active role of lay societies devoted to celiac disease are of help in achieving this definitive goal, that is a good clinical and histopathologic response to a gluten-free diet." @default.
• W2070017821 created "2016-06-24" @default.
• W2070017821 creator A5003543575 @default.
• W2070017821 creator A5079910350 @default.
• W2070017821 creator A5087372337 @default.
• W2070017821 date "2004-01-01" @default.
• W2070017821 modified "2023-09-23" @default.
• W2070017821 title "Complete small intestinal mucosal recovery is obtainable in the treatment of celiac disease" @default.
• W2070017821 cites W1973788606 @default.
• W2070017821 cites W2021277967 @default.
• W2070017821 cites W2051252749 @default.
• W2070017821 cites W2080985727 @default.
• W2070017821 cites W2082346562 @default.
• W2070017821 cites W2106392301 @default.
• W2070017821 cites W2321872434 @default.
• W2070017821 cites W2395195010 @default.
• W2070017821 doi "https://doi.org/10.1016/s0016-5107(03)01311-7" @default.
• W2070017821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14740630" @default.
• W2070017821 hasPublicationYear "2004" @default.
• W2070017821 type Work @default.
• W2070017821 sameAs 2070017821 @default.
• W2070017821 citedByCount "36" @default.
• W2070017821 countsByYear W20700178212012 @default.
• W2070017821 countsByYear W20700178212013 @default.
• W2070017821 countsByYear W20700178212014 @default.
• W2070017821 countsByYear W20700178212015 @default.
• W2070017821 countsByYear W20700178212017 @default.
• W2070017821 countsByYear W20700178212018 @default.
• W2070017821 countsByYear W20700178212021 @default.
• W2070017821 countsByYear W20700178212022 @default.
• W2070017821 crossrefType "journal-article" @default.
• W2070017821 hasAuthorship W2070017821A5003543575 @default.
• W2070017821 hasAuthorship W2070017821A5079910350 @default.
• W2070017821 hasAuthorship W2070017821A5087372337 @default.
• W2070017821 hasConcept C126322002 @default.
• W2070017821 hasConcept C2779134260 @default.
• W2070017821 hasConcept C71924100 @default.
• W2070017821 hasConcept C90924648 @default.
• W2070017821 hasConceptScore W2070017821C126322002 @default.
• W2070017821 hasConceptScore W2070017821C2779134260 @default.
• W2070017821 hasConceptScore W2070017821C71924100 @default.
• W2070017821 hasConceptScore W2070017821C90924648 @default.
• W2070017821 hasIssue "1" @default.
• W2070017821 hasLocation W20700178211 @default.
• W2070017821 hasLocation W20700178212 @default.
• W2070017821 hasOpenAccess W2070017821 @default.
• W2070017821 hasPrimaryLocation W20700178211 @default.
• W2070017821 hasRelatedWork W1506200166 @default.
• W2070017821 hasRelatedWork W1995515455 @default.
• W2070017821 hasRelatedWork W2048182022 @default.
• W2070017821 hasRelatedWork W2080531066 @default.
• W2070017821 hasRelatedWork W2604872355 @default.
• W2070017821 hasRelatedWork W2748952813 @default.
• W2070017821 hasRelatedWork W2899084033 @default.
• W2070017821 hasRelatedWork W3031052312 @default.
• W2070017821 hasRelatedWork W3032375762 @default.
• W2070017821 hasRelatedWork W3108674512 @default.
• W2070017821 hasVolume "59" @default.
• W2070017821 isParatext "false" @default.
• W2070017821 isRetracted "false" @default.
• W2070017821 magId "2070017821" @default.
• W2070017821 workType "article" @default.