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• W2070022998 abstract "Both p16(INK4) and p21(Waf1) are very important negative regulators of the cell cycle. In this study we examined the effects of p21(Waf1) on the transcription of p16(INK4). We determined that p21(Waf1) can activate the transcription of p16(INK4), and that this effect is GC-box dependent. We also found that the transcription factor Sp1 plays a key role in this event. Upregulation of Sp1 contributes to the transcriptional activation and protein level of p16(INK4) mediated by p21(Waf1), and is a potential point of cooperation between the p16/pRb and p14 (ARF)/p53 tumor suppressor pathways." @default.
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• W2070022998 date "2004-03-31" @default.
• W2070022998 modified "2023-10-11" @default.
• W2070022998 title "Sp1 is involved in the transcriptional activation of p16^INK4 by p21^Waf1 in HeLa cells" @default.
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• W2070022998 doi "https://doi.org/10.1016/s0014-5793(04)00352-7" @default.
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