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- W2070026322 abstract "Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death. Despite improvements in the clinical management, the prognosis of PDAC remains dismal. In the present comprehensive review, we will examine the knowledge of PDAC genetics and the new insights into human genome sequencing and clonal evolution. Additionally, the biology and the role of the stroma in tumour progression and response to treatment will be presented. Furthermore, we will describe the evidence on tumour chemoresistance and radioresistance and will provide an overview on the recent advances in PDAC metabolism and circulating tumour cells. Next, we will explore the characteristics and merits of the different mouse models of PDAC. The inflammatory milieu and the immunosuppressive microenvironment mediate tumour initiation and treatment failure. Hence, we will also review the inflammatory and immune escaping mechanisms and the new immunotherapies tested in PDAC. A better understanding of the different mechanisms of tumour formation and progression will help us to identify the best targets for testing in future clinical studies of PDAC." @default.
- W2070026322 created "2016-06-24" @default.
- W2070026322 creator A5014763229 @default.
- W2070026322 creator A5021186593 @default.
- W2070026322 creator A5028206592 @default.
- W2070026322 creator A5046500317 @default.
- W2070026322 creator A5048742778 @default.
- W2070026322 creator A5062623247 @default.
- W2070026322 date "2015-01-01" @default.
- W2070026322 modified "2023-09-27" @default.
- W2070026322 title "Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic" @default.
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