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- W2070029051 abstract "Effects of C-terminal octapeptide of cholecystokinin (C8-CCK) and prostaglandins E1. E2 and F2α on noradrenaline-induced responses and 3H-noradrenaline release in the gallbladder and sphincter of Oddi of guinea pigs were examined. In the sphincter of Oddi, noradrenaline in low concentrations induced a relaxation which was blocked by either phen-tolamine or propranolol, while noradrenaline in high concentrations induced a contraction which was blocked by phentolamine. These results suggest the existence of excitatory and inhibitory α-receptors and inhibitory β-receptors in the sphincter of Oddi. In the gallbladder, the adrenergic receptors are α-excitatory and β-inhibitory. C8-CCK (10−9 g/ml) potentiated both contractile and relaxing responses to noradrenaline, in the gallbladder. The same concentration of prostaglandins potentiated only contractile response to noradrenaline. In the sphincter of Oddi, noradrenaline-induced responses were not affected by C8-CCK and prostaglandins. Prostaglandins inhibited 3H-efflux evoked by electrical stimulation, while Cs-CCK had no effect on the 3H-efflux from both preparations. These results suggest that C8-CCK enhances the contractile and relaxing responses to noradrenaline, and that prostaglandins act in a similar way on the postsynaptic response and, in addition, inhibit presynaptically the release of noradrenaline in the gallbladder. In the sphincter of Oddi, only prostaglandins inhibit the presynaptic event." @default.
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- W2070029051 date "1981-01-01" @default.
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- W2070029051 title "Effects of C-terminal octapeptide of cholecystokinin and prostaglandins on adrenergic functions in the guinea-pig gallbladder and sphincter of Oddi." @default.
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- W2070029051 doi "https://doi.org/10.1254/jjp.31.77" @default.
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