Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070033366> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2070033366 endingPage "45" @default.
- W2070033366 startingPage "35" @default.
- W2070033366 abstract "The objective of this work was to develop an in vitro model to screen possible antidotal treatments against membrane-active compounds. Toward this end, studies were conducted to examine changes in membrane potential and resistance induced by several test compounds, i.e., gramicidin D, ouabain, and minoxidil, in differentiated NG108-15 hybrid (mouse neuroblastoma X rat glioma) cells using intracellular electrodes and standard current clamp techniques. In general, changes observed were consistent with known actions of these compounds and their effects demonstrated in a number ofother systems.For example, the channel-forming ionophore gramicidin D produced severe membrane depolarization with markedly reduced resistance. Also, the Na+-K+ pump blocker ouabain produced membrane depolarization, and the potassium channel activator minoxidil produced membrane hyperpolarization. Neither ouabain nor minoxidil significantly altered input resistanceof theNG108-15 cells.Thenature of theobserved alterations combined with theconsistency apparent in concentration-response profiles suggests that this model system is suitable for screening the effects of possible antidotal treatments against these and other membraneactive compounds." @default.
- W2070033366 created "2016-06-24" @default.
- W2070033366 creator A5022900167 @default.
- W2070033366 date "1999-01-01" @default.
- W2070033366 modified "2023-09-23" @default.
- W2070033366 title "MEMBRANE POTENTIAL AND RESISTANCE CHANGES IN NG108-15 CELLS: AN IN VITRO MODEL TO STUDY MEMBRANE-ACTIVE COMPOUNDS" @default.
- W2070033366 cites W1507990006 @default.
- W2070033366 cites W1515146239 @default.
- W2070033366 cites W1925620426 @default.
- W2070033366 cites W1975909527 @default.
- W2070033366 cites W1987847765 @default.
- W2070033366 cites W1988052349 @default.
- W2070033366 cites W1991851546 @default.
- W2070033366 cites W2004752421 @default.
- W2070033366 cites W2005369799 @default.
- W2070033366 cites W2007767935 @default.
- W2070033366 cites W2030456302 @default.
- W2070033366 cites W2031881472 @default.
- W2070033366 cites W2035283816 @default.
- W2070033366 cites W2035794998 @default.
- W2070033366 cites W2059414011 @default.
- W2070033366 cites W2061415409 @default.
- W2070033366 cites W2062673686 @default.
- W2070033366 cites W2073480665 @default.
- W2070033366 cites W2073753246 @default.
- W2070033366 cites W2075109532 @default.
- W2070033366 cites W2087705211 @default.
- W2070033366 cites W2090509794 @default.
- W2070033366 cites W2093273852 @default.
- W2070033366 cites W2114372399 @default.
- W2070033366 cites W2137706896 @default.
- W2070033366 cites W2144518570 @default.
- W2070033366 cites W71959242 @default.
- W2070033366 cites W1944578697 @default.
- W2070033366 doi "https://doi.org/10.1080/105172399242816" @default.
- W2070033366 hasPublicationYear "1999" @default.
- W2070033366 type Work @default.
- W2070033366 sameAs 2070033366 @default.
- W2070033366 citedByCount "6" @default.
- W2070033366 crossrefType "journal-article" @default.
- W2070033366 hasAuthorship W2070033366A5022900167 @default.
- W2070033366 hasConcept C12554922 @default.
- W2070033366 hasConcept C131453863 @default.
- W2070033366 hasConcept C170493617 @default.
- W2070033366 hasConcept C178790620 @default.
- W2070033366 hasConcept C181911157 @default.
- W2070033366 hasConcept C185592680 @default.
- W2070033366 hasConcept C202751555 @default.
- W2070033366 hasConcept C2779014961 @default.
- W2070033366 hasConcept C2779133857 @default.
- W2070033366 hasConcept C2779650302 @default.
- W2070033366 hasConcept C4141045 @default.
- W2070033366 hasConcept C41625074 @default.
- W2070033366 hasConcept C537181965 @default.
- W2070033366 hasConcept C55493867 @default.
- W2070033366 hasConcept C66974803 @default.
- W2070033366 hasConcept C71240020 @default.
- W2070033366 hasConcept C86803240 @default.
- W2070033366 hasConcept C88045685 @default.
- W2070033366 hasConcept C98274493 @default.
- W2070033366 hasConceptScore W2070033366C12554922 @default.
- W2070033366 hasConceptScore W2070033366C131453863 @default.
- W2070033366 hasConceptScore W2070033366C170493617 @default.
- W2070033366 hasConceptScore W2070033366C178790620 @default.
- W2070033366 hasConceptScore W2070033366C181911157 @default.
- W2070033366 hasConceptScore W2070033366C185592680 @default.
- W2070033366 hasConceptScore W2070033366C202751555 @default.
- W2070033366 hasConceptScore W2070033366C2779014961 @default.
- W2070033366 hasConceptScore W2070033366C2779133857 @default.
- W2070033366 hasConceptScore W2070033366C2779650302 @default.
- W2070033366 hasConceptScore W2070033366C4141045 @default.
- W2070033366 hasConceptScore W2070033366C41625074 @default.
- W2070033366 hasConceptScore W2070033366C537181965 @default.
- W2070033366 hasConceptScore W2070033366C55493867 @default.
- W2070033366 hasConceptScore W2070033366C66974803 @default.
- W2070033366 hasConceptScore W2070033366C71240020 @default.
- W2070033366 hasConceptScore W2070033366C86803240 @default.
- W2070033366 hasConceptScore W2070033366C88045685 @default.
- W2070033366 hasConceptScore W2070033366C98274493 @default.
- W2070033366 hasIssue "1" @default.
- W2070033366 hasLocation W20700333661 @default.
- W2070033366 hasOpenAccess W2070033366 @default.
- W2070033366 hasPrimaryLocation W20700333661 @default.
- W2070033366 hasRelatedWork W1982684952 @default.
- W2070033366 hasRelatedWork W2010897136 @default.
- W2070033366 hasRelatedWork W2042545009 @default.
- W2070033366 hasRelatedWork W2061354090 @default.
- W2070033366 hasRelatedWork W2070033366 @default.
- W2070033366 hasRelatedWork W2140774907 @default.
- W2070033366 hasRelatedWork W2240300191 @default.
- W2070033366 hasRelatedWork W2268223071 @default.
- W2070033366 hasRelatedWork W2409871305 @default.
- W2070033366 hasRelatedWork W2411060286 @default.
- W2070033366 hasVolume "9" @default.
- W2070033366 isParatext "false" @default.
- W2070033366 isRetracted "false" @default.
- W2070033366 magId "2070033366" @default.
- W2070033366 workType "article" @default.