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- W2070035368 abstract "Abstract Expressions of proliferating cell nuclear antigen (PCNA) in various liver diseases were investigated with an immunohistochemical method, using liver biopsy specimens. The disease category and the number of cases were as follows: nonspecific change 10, acute hepatitis 11, chronic inactive hepatitis 13, chronic active hepatitis without cirrhosis (CAH) 30, liver cirrhosis 10, and hepatocellular carcinoma 10. Significantly higher expression of PCNA was seen in chronic active hepatitis (CAH), compared to other disease groups. The PCNA expression in CAH was not correlated with the conventional histological evaluation of hepatitis activity or Knodell's hepatitis activity index. Among laboratory data, indocyanine green retention rate was negatively correlated with the PCNA expression ( r = −0.467 , P ). Significantly higher expression was also noted in acute hepatitis and hepatocellular carcinoma, compared with nonspecific change or liver cirrhosis. Although clinical significance of PCNA in chronic active hepatitis remains to be elucidated, PCNA might be a new histological marker of regeneration in benign liver disease." @default.
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- W2070035368 date "1994-11-01" @default.
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- W2070035368 title "Expression of proliferating cell nuclear antigen in benign liver diseases" @default.
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- W2070035368 doi "https://doi.org/10.1016/0928-4346(94)90037-x" @default.
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