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• W2070035507 abstract "Previous studies have shown that a western diet impairs, whereas physical exercise enhances hippocampus-dependent learning and memory. Both diet and exercise influence expression of hippocampal brain-derived neurotrophic factor (BDNF), which is associated with improved cognition. We hypothesized that exercise reverses diet-induced cognitive decline while increasing hippocampal BDNF.To test the effects of exercise on hippocampal-dependent memory, we compared cognitive scores of Sprague-Dawley rats exercised by voluntary running wheel (RW) access or forced treadmill (TM) to sedentary (Sed) animals. Memory was tested by two-way active avoidance test (TWAA), in which animals are exposed to a brief shock in a specific chamber area. When an animal avoids, escapes or has reduced latency to do either, this is considered a measure of memory. In a second experiment, rats were fed either a high-fat diet or control diet for 16 weeks, then randomly assigned to running wheel access or sedentary condition, and TWAA memory was tested once a week for 7 weeks of exercise intervention.Both groups of exercised animals had improved memory as indicated by reduced latency to avoid and escape shock, and increased avoid and escape episodes (p<0.05). Exposure to a high-fat diet resulted in poor performance during both the acquisition and retrieval phases of the memory test as compared to controls. Exercise reversed high-fat diet-induced memory impairment, and increased brain-derived neurotrophic factor (BDNF) in neurons of the hippocampal CA3 region.These data suggest that exercise improves memory retrieval, particularly with respect to avoiding aversive stimuli, and may be beneficial in protecting against diet induced cognitive decline, likely via elevated BDNF in neurons of the CA3 region." @default.
• W2070035507 created "2016-06-24" @default.
• W2070035507 creator A5010432612 @default.
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• W2070035507 creator A5090515985 @default.
• W2070035507 date "2014-10-01" @default.
• W2070035507 modified "2023-09-26" @default.
• W2070035507 title "Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons" @default.
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• W2070035507 doi "https://doi.org/10.1016/j.nlm.2014.04.006" @default.
• W2070035507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143428" @default.
• W2070035507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24755094" @default.
• W2070035507 hasPublicationYear "2014" @default.
• W2070035507 type Work @default.

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