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• W2070036135 abstract "A review of the literature in both animals and humans reveals that changes in sex hormone have often been associated with changes in behavioral and mental abilities. Previously published research from our laboratory, and others, provides strong evidence that P300 (latency) event-related potential (ERP), a marker of neuronal processing speed, is an accurate predictor of early memory impairment in both males and females across a wide age range. It is our hypothesis, given the vast literature on the subject, that coupling growth hormones (insulin-like growth factor-I, (IGF-I) and insulin-like growth factor binding protein 3 (IGF-BP3)), P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting. To support this hypothesis, we utilized structural equation modeling (SEM) parameter estimates to determine the relationship between aging and memory, as mediated by growth hormone (GH) levels (indirectly measured through the insulin-like growth factor system), P300 latency and TOVA, putative neurocognitive predictors tested in this study. An SEM was developed hypothesizing a causal directive path, leading from age to memory, mediated by IGF-1 and IGF-BP3, P300 latency (speed), and TOVA decrements. An increase in age was accompanied by a decrease in IGF-1 and IGF-BP3, an increase in P300 latency, a prolongation in TOVA response time, and a decrease in memory functioning. Moreover, independent of age, decreases in IGF-1 and IGF-BP3, were accompanied by increases in P300 latency, and were accompanied by increases in TOVA response time. Finally, increases in P300 latency were accompanied by decreased memory function, both directly and indirectly through mediation of TOVA response time. In summary, this is the first report utilizing SEM to reveal the finding that aging affects memory function negatively through mediation of decreased IGF-1 and IGF-BP3, and increased P300 latency (delayed attention and processing speed)." @default.
• W2070036135 created "2016-06-24" @default.
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• W2070036135 date "2007-05-12" @default.
• W2070036135 modified "2023-09-25" @default.
• W2070036135 title "Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: Evidence supported by structural equation modeling (SEM) parameter estimates" @default.
• W2070036135 cites W1486663554 @default.
• W2070036135 cites W1511713572 @default.
• W2070036135 cites W1568526783 @default.
• W2070036135 cites W157734437 @default.
• W2070036135 cites W171118067 @default.
• W2070036135 cites W1922007189 @default.
• W2070036135 cites W1965154263 @default.
• W2070036135 cites W1965648040 @default.
• W2070036135 cites W1966766716 @default.
• W2070036135 cites W1968216390 @default.
• W2070036135 cites W1969732796 @default.
• W2070036135 cites W1970996040 @default.
• W2070036135 cites W1973578390 @default.
• W2070036135 cites W1975578384 @default.
• W2070036135 cites W1975829688 @default.
• W2070036135 cites W1975928107 @default.
• W2070036135 cites W1977374270 @default.
• W2070036135 cites W1977676423 @default.
• W2070036135 cites W1978425813 @default.
• W2070036135 cites W1978768469 @default.
• W2070036135 cites W1979505121 @default.
• W2070036135 cites W1981843591 @default.
• W2070036135 cites W1985670156 @default.
• W2070036135 cites W1987307065 @default.
• W2070036135 cites W1988940818 @default.
• W2070036135 cites W1989643757 @default.
• W2070036135 cites W1989849487 @default.
• W2070036135 cites W1994477783 @default.
• W2070036135 cites W1999131363 @default.
• W2070036135 cites W1999664376 @default.
• W2070036135 cites W2001229549 @default.
• W2070036135 cites W2002263024 @default.
• W2070036135 cites W2002762623 @default.
• W2070036135 cites W2005574634 @default.
• W2070036135 cites W2008056503 @default.
• W2070036135 cites W2010891475 @default.
• W2070036135 cites W2011078956 @default.
• W2070036135 cites W2011607937 @default.
• W2070036135 cites W2011837326 @default.
• W2070036135 cites W2012425859 @default.
• W2070036135 cites W2012820064 @default.
• W2070036135 cites W2013761387 @default.
• W2070036135 cites W2018201949 @default.
• W2070036135 cites W2021585613 @default.
• W2070036135 cites W2024157577 @default.
• W2070036135 cites W2024249305 @default.
• W2070036135 cites W2024673490 @default.
• W2070036135 cites W2027150507 @default.
• W2070036135 cites W2027731006 @default.
• W2070036135 cites W2028547764 @default.
• W2070036135 cites W2030637641 @default.
• W2070036135 cites W2034175214 @default.
• W2070036135 cites W2035959692 @default.
• W2070036135 cites W2037837127 @default.
• W2070036135 cites W2040316206 @default.
• W2070036135 cites W2041776485 @default.
• W2070036135 cites W2041995932 @default.
• W2070036135 cites W2042354818 @default.
• W2070036135 cites W2046321337 @default.
• W2070036135 cites W2052654884 @default.
• W2070036135 cites W2057019373 @default.
• W2070036135 cites W2057888134 @default.
• W2070036135 cites W2063988650 @default.
• W2070036135 cites W2066385861 @default.
• W2070036135 cites W2066558048 @default.
• W2070036135 cites W2066789280 @default.
• W2070036135 cites W2067728536 @default.
• W2070036135 cites W2068411486 @default.
• W2070036135 cites W2074078257 @default.
• W2070036135 cites W2074257075 @default.
• W2070036135 cites W2075568717 @default.
• W2070036135 cites W2076942375 @default.
• W2070036135 cites W2077647993 @default.
• W2070036135 cites W2080334719 @default.
• W2070036135 cites W2083172499 @default.
• W2070036135 cites W2084915564 @default.
• W2070036135 cites W2085279737 @default.
• W2070036135 cites W2085826558 @default.
• W2070036135 cites W2086716919 @default.
• W2070036135 cites W2088617390 @default.
• W2070036135 cites W2090724400 @default.

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