FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070036562> ?p ?o ?g. }

• W2070036562 endingPage "144" @default.
• W2070036562 startingPage "140" @default.
• W2070036562 abstract "An appreciable increase in G(M3) with a concomitant decrease in some neolacto-series gangliosides was observed during differentiation of human colonic carcinoma HCT 116 cells induced by a differentiating agent. When the cells were treated with brefeldin A (BFA), a striking increase in de novo biosynthesis of G(M3) and a decrease in biosynthesis of neolactoseries gangliosides were observed after 6 h. Clear morphological changes to differentiated epithelial cells and an arrest of cells in the G0/G1 phase of the cell cycle were observed after 1 day of treatment. Then the cells were led to apoptosis. This activity was not affected by forskolin, which antagonizes the effects of BFA on protein transport and the Golgi apparatus. These results suggest that the differentiation-inducing activity of BFA might be due to its modulatory effect on ganglioside biosynthesis, and that a specific change in ganglioside pattern is an essential prerequisite for induction of differentiation, providing a novel target for differentiation therapy of cancer." @default.
• W2070036562 created "2016-06-24" @default.
• W2070036562 creator A5016221594 @default.
• W2070036562 creator A5019290673 @default.
• W2070036562 creator A5043126305 @default.
• W2070036562 creator A5074690632 @default.
• W2070036562 creator A5090298018 @default.
• W2070036562 date "1999-06-17" @default.
• W2070036562 modified "2023-09-26" @default.
• W2070036562 title "Induction of terminal differentiation and apoptosis in human colonic carcinoma cells by brefeldin A, a drug affecting ganglioside biosynthesis" @default.
• W2070036562 cites W120861911 @default.
• W2070036562 cites W148478075 @default.
• W2070036562 cites W1519577579 @default.
• W2070036562 cites W1537101375 @default.
• W2070036562 cites W1549953248 @default.
• W2070036562 cites W1583126439 @default.
• W2070036562 cites W1605606871 @default.
• W2070036562 cites W1680920356 @default.
• W2070036562 cites W1832017107 @default.
• W2070036562 cites W1980205434 @default.
• W2070036562 cites W198050042 @default.
• W2070036562 cites W1981573030 @default.
• W2070036562 cites W2017615910 @default.
• W2070036562 cites W2049618391 @default.
• W2070036562 cites W2058352411 @default.
• W2070036562 cites W2059428912 @default.
• W2070036562 cites W2084609653 @default.
• W2070036562 cites W2085937559 @default.
• W2070036562 cites W2094396583 @default.
• W2070036562 cites W2161639145 @default.
• W2070036562 cites W2169790726 @default.
• W2070036562 cites W2400642417 @default.
• W2070036562 cites W4232679028 @default.
• W2070036562 cites W4252240411 @default.
• W2070036562 doi "https://doi.org/10.1016/s0014-5793(99)00709-7" @default.
• W2070036562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10403391" @default.
• W2070036562 hasPublicationYear "1999" @default.
• W2070036562 type Work @default.
• W2070036562 sameAs 2070036562 @default.
• W2070036562 citedByCount "35" @default.
• W2070036562 countsByYear W20700365622013 @default.
• W2070036562 countsByYear W20700365622017 @default.
• W2070036562 countsByYear W20700365622019 @default.
• W2070036562 countsByYear W20700365622020 @default.
• W2070036562 countsByYear W20700365622021 @default.
• W2070036562 crossrefType "journal-article" @default.
• W2070036562 hasAuthorship W2070036562A5016221594 @default.
• W2070036562 hasAuthorship W2070036562A5019290673 @default.
• W2070036562 hasAuthorship W2070036562A5043126305 @default.
• W2070036562 hasAuthorship W2070036562A5074690632 @default.
• W2070036562 hasAuthorship W2070036562A5090298018 @default.
• W2070036562 hasConcept C104317684 @default.
• W2070036562 hasConcept C119062480 @default.
• W2070036562 hasConcept C148738053 @default.
• W2070036562 hasConcept C1491633281 @default.
• W2070036562 hasConcept C185592680 @default.
• W2070036562 hasConcept C190283241 @default.
• W2070036562 hasConcept C202751555 @default.
• W2070036562 hasConcept C2776601000 @default.
• W2070036562 hasConcept C2777331542 @default.
• W2070036562 hasConcept C2779276759 @default.
• W2070036562 hasConcept C2779982571 @default.
• W2070036562 hasConcept C2781121885 @default.
• W2070036562 hasConcept C2781373781 @default.
• W2070036562 hasConcept C54355233 @default.
• W2070036562 hasConcept C553450214 @default.
• W2070036562 hasConcept C55493867 @default.
• W2070036562 hasConcept C81885089 @default.
• W2070036562 hasConcept C86803240 @default.
• W2070036562 hasConcept C95444343 @default.
• W2070036562 hasConceptScore W2070036562C104317684 @default.
• W2070036562 hasConceptScore W2070036562C119062480 @default.
• W2070036562 hasConceptScore W2070036562C148738053 @default.
• W2070036562 hasConceptScore W2070036562C1491633281 @default.
• W2070036562 hasConceptScore W2070036562C185592680 @default.
• W2070036562 hasConceptScore W2070036562C190283241 @default.
• W2070036562 hasConceptScore W2070036562C202751555 @default.
• W2070036562 hasConceptScore W2070036562C2776601000 @default.
• W2070036562 hasConceptScore W2070036562C2777331542 @default.
• W2070036562 hasConceptScore W2070036562C2779276759 @default.
• W2070036562 hasConceptScore W2070036562C2779982571 @default.
• W2070036562 hasConceptScore W2070036562C2781121885 @default.
• W2070036562 hasConceptScore W2070036562C2781373781 @default.
• W2070036562 hasConceptScore W2070036562C54355233 @default.
• W2070036562 hasConceptScore W2070036562C553450214 @default.
• W2070036562 hasConceptScore W2070036562C55493867 @default.
• W2070036562 hasConceptScore W2070036562C81885089 @default.
• W2070036562 hasConceptScore W2070036562C86803240 @default.
• W2070036562 hasConceptScore W2070036562C95444343 @default.
• W2070036562 hasIssue "1-2" @default.
• W2070036562 hasLocation W20700365621 @default.
• W2070036562 hasLocation W20700365622 @default.
• W2070036562 hasOpenAccess W2070036562 @default.
• W2070036562 hasPrimaryLocation W20700365621 @default.
• W2070036562 hasRelatedWork W1853819535 @default.
• W2070036562 hasRelatedWork W1967712753 @default.
• W2070036562 hasRelatedWork W1968774879 @default.
• W2070036562 hasRelatedWork W2000021860 @default.

• next