FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070038352> ?p ?o ?g. }

• W2070038352 endingPage "462" @default.
• W2070038352 startingPage "453" @default.
• W2070038352 abstract "The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia both hind limbs were occluded with tourniquets. Following ischemia period for 60 min, the tourniquets were removed allowing reperfusion for 120 min. The IR group received 0.5 ml of saline while the IR + AB group received 3-AB (10 mg kg−1 intraperitoneally). The IR + DMSO group was given 0.5 ml 10% DMSO 30 min before the removal of the tourniquets. The control group received 0.5 ml saline and the AB group received 0.5 ml 3-AB (10 mg kg−1) intraperitoneally. At the end of the reperfusion period, mid-line sternotomy was performed. Blood samples were taken with cardiac puncture. Bronchoalveolar lavage (BAL) of the left lung was performed with saline. Right lung was preserved for histopathological evaluation and biochemical examination. Lung tissue malondialdehyde (MDA) and 3-nitrotyrosine levels, myeloperoxidase and Na+/K+ ATP-ase activities, wet to dry weight ratios, and plasma and BAL fluid MDA levels were determined. Histopathological evaluation was performed, too. Hind limb IR caused significant increase in the lung tissue 3-NT to total tyrosine ratio (p = 0.014), wet to dry weight ratio (p = 0.000), MPO activity (p = 0.000), and MDA levels (p = 0.000). The animals treated with 3-AB showed a statistically significant decrease in these values (p < 0.05). Na+/K+ ATP-ase activity which was found to be decreased significantly with IR, returned to near normal levels with 3-AB treatment. Additionally, lung tissue injury in IR group characterized with moderate interstitial congestion and neutrophil infiltration, showed remarkable amelioration following 3-AB treatment. Our results strongly support the view that poly(ADP-ribose) polymerase (PARP) plays an important role in the inflammatory process in hind limb I/R-induced lung injury and as a PARP inhibitor, 3-AB seems to have a potential to treat this inflammatory injury." @default.
• W2070038352 created "2016-06-24" @default.
• W2070038352 creator A5000390546 @default.
• W2070038352 creator A5000582479 @default.
• W2070038352 creator A5008310786 @default.
• W2070038352 creator A5009008422 @default.
• W2070038352 creator A5019673982 @default.
• W2070038352 creator A5041951997 @default.
• W2070038352 creator A5050819756 @default.
• W2070038352 creator A5054524534 @default.
• W2070038352 creator A5078134634 @default.
• W2070038352 date "2005-05-01" @default.
• W2070038352 modified "2023-10-06" @default.
• W2070038352 title "Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats" @default.
• W2070038352 cites W1584549675 @default.
• W2070038352 cites W1775749144 @default.
• W2070038352 cites W1813752852 @default.
• W2070038352 cites W1924225405 @default.
• W2070038352 cites W1964531991 @default.
• W2070038352 cites W1965693998 @default.
• W2070038352 cites W1967727360 @default.
• W2070038352 cites W1970184435 @default.
• W2070038352 cites W1970890994 @default.
• W2070038352 cites W1972155611 @default.
• W2070038352 cites W1975255909 @default.
• W2070038352 cites W1979363274 @default.
• W2070038352 cites W1994314886 @default.
• W2070038352 cites W1995715636 @default.
• W2070038352 cites W1997253947 @default.
• W2070038352 cites W2004103693 @default.
• W2070038352 cites W2005357317 @default.
• W2070038352 cites W2005706069 @default.
• W2070038352 cites W2009781172 @default.
• W2070038352 cites W2012464463 @default.
• W2070038352 cites W2015705072 @default.
• W2070038352 cites W2016939768 @default.
• W2070038352 cites W2020500551 @default.
• W2070038352 cites W2023047703 @default.
• W2070038352 cites W2023908986 @default.
• W2070038352 cites W2030297534 @default.
• W2070038352 cites W2033562010 @default.
• W2070038352 cites W2034703108 @default.
• W2070038352 cites W2035611840 @default.
• W2070038352 cites W2037190481 @default.
• W2070038352 cites W2038371393 @default.
• W2070038352 cites W2042569561 @default.
• W2070038352 cites W2044161738 @default.
• W2070038352 cites W2057706543 @default.
• W2070038352 cites W2061298493 @default.
• W2070038352 cites W2064572570 @default.
• W2070038352 cites W2086978501 @default.
• W2070038352 cites W2094266637 @default.
• W2070038352 cites W2096741239 @default.
• W2070038352 cites W2100569416 @default.
• W2070038352 cites W2108504830 @default.
• W2070038352 cites W2145991206 @default.
• W2070038352 cites W2148359763 @default.
• W2070038352 cites W2157016693 @default.
• W2070038352 cites W2159181061 @default.
• W2070038352 cites W2300459514 @default.
• W2070038352 doi "https://doi.org/10.1016/j.phrs.2004.11.007" @default.
• W2070038352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15749460" @default.
• W2070038352 hasPublicationYear "2005" @default.
• W2070038352 type Work @default.
• W2070038352 sameAs 2070038352 @default.
• W2070038352 citedByCount "54" @default.
• W2070038352 countsByYear W20700383522012 @default.
• W2070038352 countsByYear W20700383522013 @default.
• W2070038352 countsByYear W20700383522014 @default.
• W2070038352 countsByYear W20700383522015 @default.
• W2070038352 countsByYear W20700383522016 @default.
• W2070038352 countsByYear W20700383522017 @default.
• W2070038352 countsByYear W20700383522018 @default.
• W2070038352 countsByYear W20700383522019 @default.
• W2070038352 countsByYear W20700383522020 @default.
• W2070038352 countsByYear W20700383522021 @default.
• W2070038352 countsByYear W20700383522022 @default.
• W2070038352 crossrefType "journal-article" @default.
• W2070038352 hasAuthorship W2070038352A5000390546 @default.
• W2070038352 hasAuthorship W2070038352A5000582479 @default.
• W2070038352 hasAuthorship W2070038352A5008310786 @default.
• W2070038352 hasAuthorship W2070038352A5009008422 @default.
• W2070038352 hasAuthorship W2070038352A5019673982 @default.
• W2070038352 hasAuthorship W2070038352A5041951997 @default.
• W2070038352 hasAuthorship W2070038352A5050819756 @default.
• W2070038352 hasAuthorship W2070038352A5054524534 @default.
• W2070038352 hasAuthorship W2070038352A5078134634 @default.
• W2070038352 hasConcept C126322002 @default.
• W2070038352 hasConcept C134018914 @default.
• W2070038352 hasConcept C142724271 @default.
• W2070038352 hasConcept C16685009 @default.
• W2070038352 hasConcept C185592680 @default.
• W2070038352 hasConcept C2776151105 @default.
• W2070038352 hasConcept C2777397205 @default.
• W2070038352 hasConcept C2777714996 @default.
• W2070038352 hasConcept C2777961210 @default.
• W2070038352 hasConcept C2778401633 @default.
• W2070038352 hasConcept C42219234 @default.

• next