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• W2070041054 abstract "<i>Pseudomonas</i><i>aeruginosa</i><i>(PA)</i> is a Gram-negative bacterial pathogen commonly associated with chronic lung infections. Previously, we have identified several <i>PA </i>virulence factors that are important for resistance to the surfactant protein-A (SP-A), a pulmonary innate immunity protein that mediates bacterial opsonization and membrane permeabilization. In this study, we demonstrate that the type IV pilus (Tfp) is important in the resistance of <i>PA</i> to the antibacterial effects of SP-A. The Tfp-deficient mutant <i>&#x0394;pilA</i> is severely attenuated in an acute pneumonia model of infection in the lungs of wild-type mice, but is virulent in the lungs of SP-A^-/- mice. The <i>&#x0394;pilA</i> bacteria are more susceptible to SP-A-mediated aggregation and opsonization. In addition, the integrity of the outer membranes of <i>&#x0394;pilA</i> bacteria is compromised, rendering them more susceptible to SP-A-mediated membrane permeabilization. By comparing Tfp extension and retraction mutants, we demonstrate that the increased susceptibility of <i>&#x0394;pilA</i> to SP-A-mediated opsonization requires the total absence of Tfp from <i>PA</i> cells. Finally, we provide evidence of increased expression of nonpilus adhesin OprH that may serve as an SP-A ligand, resulting in increased phagocytosis and preferential pulmonary clearance of <i>&#x0394;pilA</i>." @default.
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• W2070041054 date "2013-09-25" @default.
• W2070041054 modified "2023-09-23" @default.
• W2070041054 title "Type IV Pilus of <b><i>Pseudomonas</i></b><b><i>aeruginosa</i></b> Confers Resistance to Antimicrobial Activities of the Pulmonary Surfactant Protein-A" @default.
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• W2070041054 doi "https://doi.org/10.1159/000354304" @default.
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