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- W2070050104 abstract "Chlorpromazine, chlorpromazine free radical and a sulfhydryl inhibitor, p-hydroxymercuribenzoate, were compared for their effects on several biochemical phenomena associated with membrane function. Chlorpromazine free radical was slightly more potent than chlorpromazine in inhibiting calcium accumulation by rat brain microsomes, but less potent in protecting synaptosomes from osmotic shock, and in inhibiting synaptosomal uptake of dopamine and norepinephrine. p-Hydroxymercuribenzoate failed to protect synaptosomes from osmotic shock. It was less effective than chlorpromazine and chlorpromazine free radical in inhibiting synaptosomal uptake of catecholamines. The present data indicate that biochemical effects of chlorpromazine such as the protection of synaptosomal membrane from osmotic shock and the inhibition of synaptosomal uptake of dopamine and norepinephrine are caused by chlorpromazine itself but not by chlorpromazine free radical. Although chlorpromazine free radical was a more potent inhibitor of synaptosomal calcium uptake than chlorpromazine, the free radical was a more potent inhibitor of synaptosomal calcium uptake than chlorpromazine, the differences in potency were markedly smaller than those on microsomal Na+, K+-ATPase previously reported from this laboratory." @default.
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- W2070050104 date "1976-08-01" @default.
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- W2070050104 title "Comparative effects of chlorpromazine and its free radical on membrane functions" @default.
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- W2070050104 doi "https://doi.org/10.1016/0006-2952(76)90410-x" @default.
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