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- W2070051550 abstract "Indomethacin, a specific prostaglandin synthetase inhibitor, was found to block ovulation in rats when scheduled at 1200h on day 4 of the cycle. The same regimen was ineffective at 1800h, but its antiovulatory efficacy was estimated to be about 50% when given at 1600h. An injection of indomethacin given concurrently with prostaglandin F2a allowed ovulation in 80%b of the test animals. None of the animals, irrespective of the drug schedule, became pregnant on mating with the fertile males but showed a remarkable decidual cell reaction (DCR) in response to unilateral uterine traumatization. The anti-ovulatioy or intinidation effect of indomethacin is discussed." @default.
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- W2070051550 date "1982-08-01" @default.
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- W2070051550 title "Inhibition of ovulation by indomethacin in rats" @default.
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- W2070051550 doi "https://doi.org/10.1016/0262-1746(82)90012-9" @default.
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