FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070053008> ?p ?o ?g. }

• W2070053008 endingPage "692" @default.
• W2070053008 startingPage "684" @default.
• W2070053008 abstract "The kinetics of the specific irreversible reaction of a snake neurotoxin, alpha-bungarotoxin, with the acetylcholine receptor of electroplax membrane preparations have been investigated. The effects of activators (decamethonium, carbamylcholine) and inhibitors (alpha-bungarotoxin, d-tubocurarine) of neural transmission on this reaction have been measured and the following new information obtained. (1) The irreversible reaction is preceded by the reversible formation of toxin-receptor complexes. (2) Two types of receptor binding site exist. d-Tubocurarine directly competes with the toxin for one type of binding site. Decamethonium and carbamylcholine are noncompetitive inhibitors of the toxin reaction. (3) The data are inconsistent with binding sites on separate and distinct molecules or with preexisting nonequivalent binding sites. A simple model is proposed to explain both the kinetic data and equilibrium measurements which indicated that activators and inhibitors of neural transmission compete for only one-half of the receptor sites available to them. The model proposes that for the compounds investigated the binding sites of activators do not overlap with those of inhibitors and the ligand-induced conformational changes of the receptor result in changes in the affinities of the binding sites. The model is simple and is based on mechanisms which have been found to be valid for many well-characterized regulatory enzymes." @default.
• W2070053008 created "2016-06-24" @default.
• W2070053008 creator A5018000621 @default.
• W2070053008 creator A5057891886 @default.
• W2070053008 creator A5069315069 @default.
• W2070053008 creator A5072817001 @default.
• W2070053008 creator A5090443562 @default.
• W2070053008 date "1977-02-22" @default.
• W2070053008 modified "2023-10-17" @default.
• W2070053008 title "Allosteric interactions between the membrane-bound acetylcholine receptor and chemical mediators. Kinetic studies" @default.
• W2070053008 cites W1158770474 @default.
• W2070053008 cites W1506578135 @default.
• W2070053008 cites W170584368 @default.
• W2070053008 cites W1970396499 @default.
• W2070053008 cites W1982218403 @default.
• W2070053008 cites W1984726704 @default.
• W2070053008 cites W1988622146 @default.
• W2070053008 cites W1992714515 @default.
• W2070053008 cites W1995559873 @default.
• W2070053008 cites W1998093640 @default.
• W2070053008 cites W1999099179 @default.
• W2070053008 cites W2005392755 @default.
• W2070053008 cites W2005845627 @default.
• W2070053008 cites W2009652285 @default.
• W2070053008 cites W2018203974 @default.
• W2070053008 cites W2020966761 @default.
• W2070053008 cites W2024990200 @default.
• W2070053008 cites W2030346033 @default.
• W2070053008 cites W2031530213 @default.
• W2070053008 cites W2035070135 @default.
• W2070053008 cites W2037251446 @default.
• W2070053008 cites W2040995573 @default.
• W2070053008 cites W2041092154 @default.
• W2070053008 cites W2053413143 @default.
• W2070053008 cites W2055889678 @default.
• W2070053008 cites W2072323381 @default.
• W2070053008 cites W2077557340 @default.
• W2070053008 cites W2079901359 @default.
• W2070053008 cites W2093145040 @default.
• W2070053008 cites W2111301002 @default.
• W2070053008 cites W2134218003 @default.
• W2070053008 cites W2153930508 @default.
• W2070053008 cites W2294969525 @default.
• W2070053008 cites W3181267633 @default.
• W2070053008 cites W49259708 @default.
• W2070053008 cites W572404395 @default.
• W2070053008 doi "https://doi.org/10.1021/bi00623a020" @default.
• W2070053008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/836808" @default.
• W2070053008 hasPublicationYear "1977" @default.
• W2070053008 type Work @default.
• W2070053008 sameAs 2070053008 @default.
• W2070053008 citedByCount "45" @default.
• W2070053008 crossrefType "journal-article" @default.
• W2070053008 hasAuthorship W2070053008A5018000621 @default.
• W2070053008 hasAuthorship W2070053008A5057891886 @default.
• W2070053008 hasAuthorship W2070053008A5069315069 @default.
• W2070053008 hasAuthorship W2070053008A5072817001 @default.
• W2070053008 hasAuthorship W2070053008A5090443562 @default.
• W2070053008 hasConcept C107824862 @default.
• W2070053008 hasConcept C116569031 @default.
• W2070053008 hasConcept C123419017 @default.
• W2070053008 hasConcept C12554922 @default.
• W2070053008 hasConcept C166342909 @default.
• W2070053008 hasConcept C170493617 @default.
• W2070053008 hasConcept C181199279 @default.
• W2070053008 hasConcept C185592680 @default.
• W2070053008 hasConcept C2777186327 @default.
• W2070053008 hasConcept C2778506399 @default.
• W2070053008 hasConcept C2780283098 @default.
• W2070053008 hasConcept C2780358027 @default.
• W2070053008 hasConcept C2909005528 @default.
• W2070053008 hasConcept C55493867 @default.
• W2070053008 hasConcept C71240020 @default.
• W2070053008 hasConcept C80161118 @default.
• W2070053008 hasConcept C86803240 @default.
• W2070053008 hasConceptScore W2070053008C107824862 @default.
• W2070053008 hasConceptScore W2070053008C116569031 @default.
• W2070053008 hasConceptScore W2070053008C123419017 @default.
• W2070053008 hasConceptScore W2070053008C12554922 @default.
• W2070053008 hasConceptScore W2070053008C166342909 @default.
• W2070053008 hasConceptScore W2070053008C170493617 @default.
• W2070053008 hasConceptScore W2070053008C181199279 @default.
• W2070053008 hasConceptScore W2070053008C185592680 @default.
• W2070053008 hasConceptScore W2070053008C2777186327 @default.
• W2070053008 hasConceptScore W2070053008C2778506399 @default.
• W2070053008 hasConceptScore W2070053008C2780283098 @default.
• W2070053008 hasConceptScore W2070053008C2780358027 @default.
• W2070053008 hasConceptScore W2070053008C2909005528 @default.
• W2070053008 hasConceptScore W2070053008C55493867 @default.
• W2070053008 hasConceptScore W2070053008C71240020 @default.
• W2070053008 hasConceptScore W2070053008C80161118 @default.
• W2070053008 hasConceptScore W2070053008C86803240 @default.
• W2070053008 hasIssue "4" @default.
• W2070053008 hasLocation W20700530081 @default.
• W2070053008 hasLocation W20700530082 @default.
• W2070053008 hasOpenAccess W2070053008 @default.
• W2070053008 hasPrimaryLocation W20700530081 @default.
• W2070053008 hasRelatedWork W1859726139 @default.

• next