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- W2070057951 abstract "Abstract Subcutaneous injections of O,O'-diacetylapomorphine, at doses of 0.1 to 10.0 mg kg , produced stereotyped gnawing behaviour in the rat, indistinguishable from that induced by apomorphine. The dose-response relationship and time course of this effect were similar for the two drugs, although the ester appeared to be somewhat more potent and longer-lasting at higher doses. While apomorphine had no behavioural effects when given orally at doses up to 100 mg kg , diacetylapomorphine produced discernible stereotypy at oral doses as low as 10 mg kg . The injection of diacetylapomorphine into animals previously lesioned electrothermally in the left nigro-striatal tract provoked turning behaviour toward the side contralateral to the lesions, with an effectiveness similar to that of apomorphine. Apomorphine, but not diacetylapomorphine, stimulated the production of cyclic AMP when incubated with homogenates of corpus striatum. In analogous experiments, N,N-dimethyldopamine, but not its ester, O,O'-diacetyl-N,N-dimethyldopamine (another apparent agonist of central dopamine receptors in vivo), also stimulated the production of cyclic AMP in homogenates, and a similar failure to stimulate the production of cyclic AMP was obtained with O,O'-dibenzylapomorphine, which had prolonged behavioural effects in vivo. These results are compatible with the conclusion that catechol esters of certain structural analogues of dopamine can be hydrolysed in vivo to yield free catechols capable of stimulating central dopamine receptors." @default.
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- W2070057951 title "Esters of apomorphine and N,N-dimethyldopamine as agonists of dopamine receptors in the rat brain in vivo" @default.
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- W2070057951 doi "https://doi.org/10.1016/0028-3908(75)90097-0" @default.
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