Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070067046> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2070067046 endingPage "319" @default.
- W2070067046 startingPage "314" @default.
- W2070067046 abstract "A bstract : Thrombopoietin, the long sought primary regulator of thrombopoiesis, was cloned four years ago. In addition to its fulfilling most, if not all, of the expected biological activities relating to megakaryocyte and platelet development, the availability of the recombinant hormone and reagents to characterize its receptor have allowed detailed investigation of additional biological activities. In cultures of purified populations of candidate stem cells, thrombopoietin supports the survival, and aubments the proliferation of hematopoietic stem cells when present together with interleukin‐3 or steel factor. The progeny of such cultures are not skewed in their developmental potential; colony‐forming cells of all lineages arise from thrombopoietion‐stimulated stem cells. Evidence for an important effect of thrombopoietin on stem cell physiology in vivo are equally compelling. Genetic elimination of thrombopoietin or its receptor leads to a profound reduction not only of megakaryocytes and platelets, but also of committed myeloid progenitors of all types, primitive progenitors and hematopoietic stem cells. When administered to animals, thrombopoietin profoundly stimulates thrombopoiesis and enhances the number of hematopoietic progenitor cells of all lineages, and when used in most animal models of myelosuppressive therapy, accelerates the recovery of platelet, erythrocyte and leukocyte production. Thus, thrombopoietin appears to be more than a lineage‐restricted growth factor." @default.
- W2070067046 created "2016-06-24" @default.
- W2070067046 creator A5008851883 @default.
- W2070067046 date "1999-04-01" @default.
- W2070067046 modified "2023-09-27" @default.
- W2070067046 title "Thrombopoietin and Hematopoietic Stem Cell Development" @default.
- W2070067046 cites W134922517 @default.
- W2070067046 cites W137557781 @default.
- W2070067046 cites W143865877 @default.
- W2070067046 cites W1552274890 @default.
- W2070067046 cites W193519295 @default.
- W2070067046 cites W1965375035 @default.
- W2070067046 cites W1971833736 @default.
- W2070067046 cites W19721907 @default.
- W2070067046 cites W1983612778 @default.
- W2070067046 cites W1992704301 @default.
- W2070067046 cites W1996093792 @default.
- W2070067046 cites W1997632886 @default.
- W2070067046 cites W2009966623 @default.
- W2070067046 cites W2010196417 @default.
- W2070067046 cites W2022261377 @default.
- W2070067046 cites W2058575876 @default.
- W2070067046 cites W2062853747 @default.
- W2070067046 cites W2074972102 @default.
- W2070067046 cites W2083466354 @default.
- W2070067046 cites W2088255007 @default.
- W2070067046 cites W2088340306 @default.
- W2070067046 cites W2143531841 @default.
- W2070067046 cites W2151582425 @default.
- W2070067046 cites W2162839120 @default.
- W2070067046 cites W2230842386 @default.
- W2070067046 cites W2256952023 @default.
- W2070067046 cites W2263191133 @default.
- W2070067046 cites W2266255187 @default.
- W2070067046 cites W2272909078 @default.
- W2070067046 cites W2273652336 @default.
- W2070067046 cites W2281631393 @default.
- W2070067046 cites W2343448346 @default.
- W2070067046 cites W2406589751 @default.
- W2070067046 cites W84916623 @default.
- W2070067046 doi "https://doi.org/10.1111/j.1749-6632.1999.tb08475.x" @default.
- W2070067046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10372133" @default.
- W2070067046 hasPublicationYear "1999" @default.
- W2070067046 type Work @default.
- W2070067046 sameAs 2070067046 @default.
- W2070067046 citedByCount "33" @default.
- W2070067046 countsByYear W20700670462015 @default.
- W2070067046 countsByYear W20700670462016 @default.
- W2070067046 countsByYear W20700670462017 @default.
- W2070067046 crossrefType "journal-article" @default.
- W2070067046 hasAuthorship W2070067046A5008851883 @default.
- W2070067046 hasConcept C109159458 @default.
- W2070067046 hasConcept C201750760 @default.
- W2070067046 hasConcept C2022786 @default.
- W2070067046 hasConcept C203014093 @default.
- W2070067046 hasConcept C2776958478 @default.
- W2070067046 hasConcept C2777863708 @default.
- W2070067046 hasConcept C2779282312 @default.
- W2070067046 hasConcept C2779705218 @default.
- W2070067046 hasConcept C28328180 @default.
- W2070067046 hasConcept C502942594 @default.
- W2070067046 hasConcept C86803240 @default.
- W2070067046 hasConcept C95444343 @default.
- W2070067046 hasConceptScore W2070067046C109159458 @default.
- W2070067046 hasConceptScore W2070067046C201750760 @default.
- W2070067046 hasConceptScore W2070067046C2022786 @default.
- W2070067046 hasConceptScore W2070067046C203014093 @default.
- W2070067046 hasConceptScore W2070067046C2776958478 @default.
- W2070067046 hasConceptScore W2070067046C2777863708 @default.
- W2070067046 hasConceptScore W2070067046C2779282312 @default.
- W2070067046 hasConceptScore W2070067046C2779705218 @default.
- W2070067046 hasConceptScore W2070067046C28328180 @default.
- W2070067046 hasConceptScore W2070067046C502942594 @default.
- W2070067046 hasConceptScore W2070067046C86803240 @default.
- W2070067046 hasConceptScore W2070067046C95444343 @default.
- W2070067046 hasIssue "1" @default.
- W2070067046 hasLocation W20700670461 @default.
- W2070067046 hasLocation W20700670462 @default.
- W2070067046 hasOpenAccess W2070067046 @default.
- W2070067046 hasPrimaryLocation W20700670461 @default.
- W2070067046 hasRelatedWork W130975678 @default.
- W2070067046 hasRelatedWork W1974516599 @default.
- W2070067046 hasRelatedWork W2070067046 @default.
- W2070067046 hasRelatedWork W2079384847 @default.
- W2070067046 hasRelatedWork W2116628453 @default.
- W2070067046 hasRelatedWork W2145139769 @default.
- W2070067046 hasRelatedWork W2187342268 @default.
- W2070067046 hasRelatedWork W3182217228 @default.
- W2070067046 hasRelatedWork W4247981861 @default.
- W2070067046 hasRelatedWork W628443920 @default.
- W2070067046 hasVolume "872" @default.
- W2070067046 isParatext "false" @default.
- W2070067046 isRetracted "false" @default.
- W2070067046 magId "2070067046" @default.
- W2070067046 workType "article" @default.