Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070067157> ?p ?o ?g. }
- W2070067157 endingPage "599" @default.
- W2070067157 startingPage "583" @default.
- W2070067157 abstract "Introduction: Solid lipid particles were introduced in the early 1990s as an alternative drug carrier system to emulsions, liposomes and polymeric microparticles. Although lipid nanoparticles have been the object of a substantial number of reviews, fewer are available on lipid microparticles (LMs), despite their distinct advantages, including biocompatibility, ease of production and characterisation, extended release properties and high loading.Areas covered: This review presents an overview of the advantages and drawbacks of LMs, that is, lipid-based particles with dimensions in the micrometre range. Specific focus is on the role of the main excipients used for LM formulations, lipids and surfactants and their effects on LM properties. An update on preparation techniques and characterisation methods are also presented, with particular emphasis on more recent technologies. The interaction of LMs with biological systems and with cells in particular is reviewed. The various LM administration routes are examined, with special attention to most recent applications (i.e., pulmonary and nasal delivery).Expert opinion: LMs represent attractive and versatile carrier systems; however, their pharmaceutical applicability has been rather limited. Investigation on the use of LMs for less-established administration routes, such as pulmonary delivery, may provide further interest within the area of LM-based systems, both in industry and in the clinic." @default.
- W2070067157 created "2016-06-24" @default.
- W2070067157 creator A5012646235 @default.
- W2070067157 creator A5052084406 @default.
- W2070067157 creator A5087142025 @default.
- W2070067157 date "2014-11-13" @default.
- W2070067157 modified "2023-10-14" @default.
- W2070067157 title "Solid lipid microparticles as an approach to drug delivery" @default.
- W2070067157 cites W1207293441 @default.
- W2070067157 cites W1579046626 @default.
- W2070067157 cites W1964026121 @default.
- W2070067157 cites W1964838591 @default.
- W2070067157 cites W1966606719 @default.
- W2070067157 cites W1966926920 @default.
- W2070067157 cites W1968539417 @default.
- W2070067157 cites W1973685311 @default.
- W2070067157 cites W1975560755 @default.
- W2070067157 cites W1976131488 @default.
- W2070067157 cites W1980803266 @default.
- W2070067157 cites W1981207284 @default.
- W2070067157 cites W1983104695 @default.
- W2070067157 cites W1983692314 @default.
- W2070067157 cites W1983817091 @default.
- W2070067157 cites W1988608079 @default.
- W2070067157 cites W1990137645 @default.
- W2070067157 cites W1991132162 @default.
- W2070067157 cites W1994274507 @default.
- W2070067157 cites W1997059713 @default.
- W2070067157 cites W2000537326 @default.
- W2070067157 cites W2001566221 @default.
- W2070067157 cites W2001984505 @default.
- W2070067157 cites W2002738924 @default.
- W2070067157 cites W2002854972 @default.
- W2070067157 cites W2009919363 @default.
- W2070067157 cites W2010063869 @default.
- W2070067157 cites W2011900552 @default.
- W2070067157 cites W2012272386 @default.
- W2070067157 cites W2012288596 @default.
- W2070067157 cites W2014972837 @default.
- W2070067157 cites W2016014805 @default.
- W2070067157 cites W2016711291 @default.
- W2070067157 cites W2018892161 @default.
- W2070067157 cites W2019649784 @default.
- W2070067157 cites W2020331396 @default.
- W2070067157 cites W2023283179 @default.
- W2070067157 cites W2024634456 @default.
- W2070067157 cites W2026514347 @default.
- W2070067157 cites W2027414332 @default.
- W2070067157 cites W2028258807 @default.
- W2070067157 cites W2028316064 @default.
- W2070067157 cites W2028761028 @default.
- W2070067157 cites W2030609925 @default.
- W2070067157 cites W2030747032 @default.
- W2070067157 cites W2033498149 @default.
- W2070067157 cites W2034221979 @default.
- W2070067157 cites W2035505238 @default.
- W2070067157 cites W2039883530 @default.
- W2070067157 cites W2041122272 @default.
- W2070067157 cites W2043941772 @default.
- W2070067157 cites W2044985759 @default.
- W2070067157 cites W2045260358 @default.
- W2070067157 cites W2046536977 @default.
- W2070067157 cites W2047372391 @default.
- W2070067157 cites W2049511402 @default.
- W2070067157 cites W2050555768 @default.
- W2070067157 cites W2050970201 @default.
- W2070067157 cites W2051292995 @default.
- W2070067157 cites W2052768789 @default.
- W2070067157 cites W2053960556 @default.
- W2070067157 cites W2054189154 @default.
- W2070067157 cites W2054435240 @default.
- W2070067157 cites W2055659352 @default.
- W2070067157 cites W2058979628 @default.
- W2070067157 cites W2070055453 @default.
- W2070067157 cites W2070174418 @default.
- W2070067157 cites W2071306094 @default.
- W2070067157 cites W2072373568 @default.
- W2070067157 cites W2073753849 @default.
- W2070067157 cites W2076903550 @default.
- W2070067157 cites W2077050915 @default.
- W2070067157 cites W2077976314 @default.
- W2070067157 cites W2079208766 @default.
- W2070067157 cites W2079890162 @default.
- W2070067157 cites W2081080885 @default.
- W2070067157 cites W2081834609 @default.
- W2070067157 cites W2082812699 @default.
- W2070067157 cites W2089479233 @default.
- W2070067157 cites W2095578934 @default.
- W2070067157 cites W2102289029 @default.
- W2070067157 cites W2103833136 @default.
- W2070067157 cites W2107488576 @default.
- W2070067157 cites W2107883084 @default.
- W2070067157 cites W2125172175 @default.
- W2070067157 cites W2130651259 @default.
- W2070067157 cites W2137397041 @default.
- W2070067157 cites W2141085937 @default.
- W2070067157 cites W2141162588 @default.
- W2070067157 cites W2142788272 @default.