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• W2070070122 abstract "Clinical stage I testicular nonseminomatous germ cell tumours (NSGCTs) are highly curable. Following orchidectomy a risk-adapted approach using active surveillance (AS), nerve-sparing retroperitoneal lymph node dissection (nsRPLND) and primary chemotherapy is recommended by the current guidelines. Clinical stage I is defined as negative or declining tumour markers to their half-life following orchidectomy and negative imaging studies of the chest, abdomen and retroperitoneum. Active surveillance can be performed in low-risk and in high-risk NSGCTs with an anticipated relapse rate of about 15% and 50%. The majority of patients will relapse with good and intermediate prognosis tumours which have to be treated with three to four cycles chemotherapy. About 25–30% of these patients will have to undergo postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for residual masses. Primary chemotherapy with one or two cycles of cisplatin (Platinol), etoposide and bleomycin (PEB) is a therapeutic option for high-risk clinical stage I NSGCT associated with a recurrence rate of only 2–3% and a minimal acute and long-term toxicity rate. nsRPLND, if performed properly, will cure about 85% of all high-risk patients with clinical stage I NSGCT without the need for chemotherapy. PC-RPLND forms an integral part of the multimodality treatment in patients with advanced testicular germ cell tumours (TGCTs). According to current guidelines and recommendations, PC-RPLND in advanced seminomas with residual tumours is only indicated if a positron emission tomography (PET) scan performed 6–8 weeks after chemotherapy is positive. In nonseminomatous TGCT, PC-RPLND is indicated for all residual radiographic lesions with negative or plateauing markers. Loss of antegrade ejaculation represents the most common long-term complication which can be prevented by a nerve-sparing or modified template resection. The relapse rate after PC-RPLND is around 12%, however it increases significantly to about 45% in cases with redo RPLND and late relapses. Patients with increasing markers should undergo salvage chemotherapy. Only select patients with elevated markers who are thought to be chemorefractory might undergo desperation PC-RPLND if all radiographically visible lesions are completely resectable. PC-RPLND requires a complex surgical approach and should be performed in experienced, tertiary referral centres only." @default.
• W2070070122 created "2016-06-24" @default.
• W2070070122 creator A5048118430 @default.
• W2070070122 creator A5087317766 @default.
• W2070070122 date "2012-05-03" @default.
• W2070070122 modified "2023-10-18" @default.
• W2070070122 title "Retroperitoneal lymphadenectomy and resection for testicular cancer: an update on best practice" @default.
• W2070070122 cites W140750605 @default.
• W2070070122 cites W1598274492 @default.
• W2070070122 cites W170472323 @default.
• W2070070122 cites W1838921188 @default.
• W2070070122 cites W1840867835 @default.
• W2070070122 cites W1866644500 @default.
• W2070070122 cites W1870544205 @default.
• W2070070122 cites W1957139198 @default.
• W2070070122 cites W1967521966 @default.
• W2070070122 cites W1968178814 @default.
• W2070070122 cites W1969569886 @default.
• W2070070122 cites W197028108 @default.
• W2070070122 cites W1973987042 @default.
• W2070070122 cites W1983747904 @default.
• W2070070122 cites W1984221389 @default.
• W2070070122 cites W1985220422 @default.
• W2070070122 cites W1987706746 @default.
• W2070070122 cites W1988598363 @default.
• W2070070122 cites W1989730401 @default.
• W2070070122 cites W1999373992 @default.
• W2070070122 cites W2000038457 @default.
• W2070070122 cites W2001346312 @default.
• W2070070122 cites W2001577692 @default.
• W2070070122 cites W2005273935 @default.
• W2070070122 cites W2006772739 @default.
• W2070070122 cites W2008804564 @default.
• W2070070122 cites W2010255514 @default.
• W2070070122 cites W2012174054 @default.
• W2070070122 cites W2017142953 @default.
• W2070070122 cites W2017927606 @default.
• W2070070122 cites W2018508517 @default.
• W2070070122 cites W2020794991 @default.
• W2070070122 cites W2021106346 @default.
• W2070070122 cites W2025016076 @default.
• W2070070122 cites W2026167589 @default.
• W2070070122 cites W2031293689 @default.
• W2070070122 cites W2034275483 @default.
• W2070070122 cites W2037271914 @default.
• W2070070122 cites W2042974128 @default.
• W2070070122 cites W2057861875 @default.
• W2070070122 cites W2058033033 @default.
• W2070070122 cites W2065722985 @default.
• W2070070122 cites W2066021065 @default.
• W2070070122 cites W2066089344 @default.
• W2070070122 cites W2070135289 @default.
• W2070070122 cites W2070761658 @default.
• W2070070122 cites W2074060480 @default.
• W2070070122 cites W2075315401 @default.
• W2070070122 cites W2080126067 @default.
• W2070070122 cites W2083683974 @default.
• W2070070122 cites W2083808201 @default.
• W2070070122 cites W2086387061 @default.
• W2070070122 cites W2087329373 @default.
• W2070070122 cites W2090083379 @default.
• W2070070122 cites W2093976357 @default.
• W2070070122 cites W2094431747 @default.
• W2070070122 cites W2099548043 @default.
• W2070070122 cites W2100896307 @default.
• W2070070122 cites W2106496119 @default.
• W2070070122 cites W2110945812 @default.
• W2070070122 cites W2111751851 @default.
• W2070070122 cites W2113419186 @default.
• W2070070122 cites W2129899774 @default.
• W2070070122 cites W2141765953 @default.
• W2070070122 cites W2145586527 @default.
• W2070070122 cites W2157263358 @default.
• W2070070122 cites W2160609571 @default.
• W2070070122 cites W2163631231 @default.
• W2070070122 cites W2165999369 @default.
• W2070070122 cites W2167768819 @default.
• W2070070122 cites W2169918231 @default.
• W2070070122 cites W2220613250 @default.
• W2070070122 cites W2253416740 @default.
• W2070070122 cites W2264832376 @default.
• W2070070122 cites W2299967106 @default.
• W2070070122 cites W2400760290 @default.
• W2070070122 cites W2418896002 @default.
• W2070070122 cites W2465248195 @default.
• W2070070122 cites W2468199091 @default.
• W2070070122 cites W3012980157 @default.
• W2070070122 cites W4236486645 @default.
• W2070070122 cites W4297914219 @default.
• W2070070122 cites W4302332384 @default.
• W2070070122 cites W2752971847 @default.
• W2070070122 doi "https://doi.org/10.1177/1756287212443170" @default.
• W2070070122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398597" @default.
• W2070070122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22852029" @default.
• W2070070122 hasPublicationYear "2012" @default.
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• W2070070122 citedByCount "49" @default.

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