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- W2070070981 abstract "Using oligonucleotide-based drugs to modulate gene expression has opened a new avenue for drug discovery. In particular small interfering RNAs (siRNAs) are being rapidly recognized as promising therapeutic tools, but their poor bioavailability limits the full realization of their clinical potential. In recent years, cumulating evidence has emerged for the role of membrane vesicles, secreted by most cells and found in all body fluids, as key mediators of information transmission between cells. Importantly, a sub-group of these termed exosomes, have recently been shown to contain various RNA species and to mediate their horizontal transfer to neighbouring- or distant recipient cells. Here, we provide a brief overview on membrane vesicles and their role in exchange of genetic information. We also describe how these natural carriers of genetic material can be harnessed to overcome the obstacle of poor delivery and allow efficient systemic delivery of exogenous siRNA across biological barriers such as the blood–brain barrier." @default.
- W2070070981 created "2016-06-24" @default.
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- W2070070981 date "2013-03-01" @default.
- W2070070981 modified "2023-10-18" @default.
- W2070070981 title "Exosomes for targeted siRNA delivery across biological barriers" @default.
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- W2070070981 cites W1874379912 @default.
- W2070070981 cites W1916491745 @default.
- W2070070981 cites W1964146045 @default.
- W2070070981 cites W1964232997 @default.
- W2070070981 cites W1967367827 @default.
- W2070070981 cites W1972365386 @default.
- W2070070981 cites W1974035668 @default.
- W2070070981 cites W1974303227 @default.
- W2070070981 cites W1977208217 @default.
- W2070070981 cites W1978227190 @default.
- W2070070981 cites W1980593265 @default.
- W2070070981 cites W1980792888 @default.
- W2070070981 cites W1981872108 @default.
- W2070070981 cites W1985175917 @default.
- W2070070981 cites W1991390602 @default.
- W2070070981 cites W1992481740 @default.
- W2070070981 cites W1996126319 @default.
- W2070070981 cites W1997269140 @default.
- W2070070981 cites W2008161734 @default.
- W2070070981 cites W2014455148 @default.
- W2070070981 cites W2014509855 @default.
- W2070070981 cites W2014753621 @default.
- W2070070981 cites W2014969441 @default.
- W2070070981 cites W2021861291 @default.
- W2070070981 cites W2027167191 @default.
- W2070070981 cites W2028989051 @default.
- W2070070981 cites W2030621748 @default.
- W2070070981 cites W2030701238 @default.
- W2070070981 cites W2038783205 @default.
- W2070070981 cites W2042751187 @default.
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- W2070070981 cites W2060221489 @default.
- W2070070981 cites W2066234893 @default.
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- W2070070981 cites W2076315676 @default.
- W2070070981 cites W2083249633 @default.
- W2070070981 cites W2086275775 @default.
- W2070070981 cites W2089150369 @default.
- W2070070981 cites W2090175640 @default.
- W2070070981 cites W2093402994 @default.
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- W2070070981 cites W2096018896 @default.
- W2070070981 cites W2097645517 @default.
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- W2070070981 cites W2106583271 @default.
- W2070070981 cites W2107008239 @default.
- W2070070981 cites W2108541168 @default.
- W2070070981 cites W2111560326 @default.
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- W2070070981 cites W2122099309 @default.
- W2070070981 cites W2124304994 @default.
- W2070070981 cites W2127677388 @default.
- W2070070981 cites W2131523986 @default.
- W2070070981 cites W2132484800 @default.
- W2070070981 cites W2143743183 @default.
- W2070070981 cites W2147116051 @default.
- W2070070981 cites W2147526777 @default.
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- W2070070981 cites W2150761119 @default.
- W2070070981 cites W2155366992 @default.
- W2070070981 cites W2156107625 @default.
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- W2070070981 cites W2167806590 @default.
- W2070070981 cites W2548381372 @default.
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- W2070070981 doi "https://doi.org/10.1016/j.addr.2012.08.008" @default.
- W2070070981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22921840" @default.
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