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• W2070086938 abstract "Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neutralizes ∼98% of tested viruses. An analysis of sera from 78 healthy HIV-1-infected donors demonstrated that 27% contained MPER-specific antibodies and 8% contained 10E8-like specificities. In contrast to other neutralizing MPER antibodies, 10E8 did not bind phospholipids, was not autoreactive, and bound cell-surface envelope. The structure of 10E8 in complex with the complete MPER revealed a site of vulnerability comprising a narrow stretch of highly conserved gp41-hydrophobic residues and a critical arginine or lysine just before the transmembrane region. Analysis of resistant HIV-1 variants confirmed the importance of these residues for neutralization. The highly conserved MPER is a target of potent, non-self-reactive neutralizing antibodies, suggesting that HIV-1 vaccines should aim to induce antibodies to this region of HIV-1 envelope glycoprotein. A novel neutralizing antibody from a healthy HIV-1-infected donor that is specific for the membrane proximal region of gp41 is reported; the antibody has high potency and breadth, is not autoreactive and does not bind phospholipids. Jinghe Huang et al. report a novel neutralizing antibody from a healthy HIV-1-infected donor that is specific for the membrane-proximal region of gp41. The antibody has high potency and breadth, is not autoreactive and does not bind phospholipids. This work demonstrates a conserved site of gp41 vulnerability that is an important target antigen for HIV neutralization, with implications for efforts to elicit broadly neutralizing antibodies with vaccines." @default.
• W2070086938 created "2016-06-24" @default.
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• W2070086938 date "2012-09-18" @default.
• W2070086938 modified "2023-10-18" @default.
• W2070086938 title "Broad and potent neutralization of HIV-1 by a gp41-specific human antibody" @default.
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• W2070086938 doi "https://doi.org/10.1038/nature11544" @default.
• W2070086938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4854285" @default.
• W2070086938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23151583" @default.
• W2070086938 hasPublicationYear "2012" @default.
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