FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070089477> ?p ?o ?g. }

• W2070089477 endingPage "77" @default.
• W2070089477 startingPage "72" @default.
• W2070089477 abstract "The occurrence of metachronous adrenocortical carcinoma has rarely been described. We report a case of a child with virilizing adrenocortical metachronous tumors that, despite several metastases, presented long-term survival (15 years). We analyzed in this tumor IGF2, IGF1R and FGFR4 gene expression, and evaluated the presence of p.R337H germline p53 mutation and somatic CTNNB1 mutation. IGF2 gene was over-expressed in both left (Weiss score 5) and right (Weiss 7) adrenocortical tumors. IGF1R expression levels were higher in the right adrenocortical tumor. FGFR4 over-expression was also detected in the right adrenocortical tumor. In addition, this patient harbors the germline p.R337H p53 mutation and loss of heterozygosity (LOH) was detected in the tumors. No somatic CTNNB1 mutations were found in both tumors. In conclusion, we demonstrated in this unusual case the over-expression of growth signaling pathways, which are molecular mechanisms previously related to adrenocortical tumorigenesis. Furthermore, the absence of somatic CTNNB1 mutations, which is a molecular marker of poor prognosis in adults, might be related to the long-term survival of this patient." @default.
• W2070089477 created "2016-06-24" @default.
• W2070089477 creator A5004035589 @default.
• W2070089477 creator A5007999327 @default.
• W2070089477 creator A5009999397 @default.
• W2070089477 creator A5023864103 @default.
• W2070089477 creator A5029771504 @default.
• W2070089477 creator A5044622003 @default.
• W2070089477 creator A5048394640 @default.
• W2070089477 creator A5061988106 @default.
• W2070089477 creator A5063428489 @default.
• W2070089477 date "2011-02-01" @default.
• W2070089477 modified "2023-10-18" @default.
• W2070089477 title "Clinical and molecular aspects of a pediatric metachronous adrenocortical tumor" @default.
• W2070089477 cites W1969330589 @default.
• W2070089477 cites W1977936925 @default.
• W2070089477 cites W1980615409 @default.
• W2070089477 cites W1989357724 @default.
• W2070089477 cites W1998500429 @default.
• W2070089477 cites W2002793570 @default.
• W2070089477 cites W2003721774 @default.
• W2070089477 cites W2028862042 @default.
• W2070089477 cites W2052071036 @default.
• W2070089477 cites W2059880490 @default.
• W2070089477 cites W2060854675 @default.
• W2070089477 cites W2074606948 @default.
• W2070089477 cites W2095417135 @default.
• W2070089477 cites W2103134006 @default.
• W2070089477 cites W2120663949 @default.
• W2070089477 cites W2120961400 @default.
• W2070089477 cites W2157610967 @default.
• W2070089477 cites W2409985384 @default.
• W2070089477 doi "https://doi.org/10.1590/s0004-27302011000100010" @default.
• W2070089477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21468523" @default.
• W2070089477 hasPublicationYear "2011" @default.
• W2070089477 type Work @default.
• W2070089477 sameAs 2070089477 @default.
• W2070089477 citedByCount "9" @default.
• W2070089477 countsByYear W20700894772012 @default.
• W2070089477 countsByYear W20700894772013 @default.
• W2070089477 countsByYear W20700894772014 @default.
• W2070089477 countsByYear W20700894772016 @default.
• W2070089477 countsByYear W20700894772017 @default.
• W2070089477 countsByYear W20700894772019 @default.
• W2070089477 countsByYear W20700894772020 @default.
• W2070089477 countsByYear W20700894772022 @default.
• W2070089477 crossrefType "journal-article" @default.
• W2070089477 hasAuthorship W2070089477A5004035589 @default.
• W2070089477 hasAuthorship W2070089477A5007999327 @default.
• W2070089477 hasAuthorship W2070089477A5009999397 @default.
• W2070089477 hasAuthorship W2070089477A5023864103 @default.
• W2070089477 hasAuthorship W2070089477A5029771504 @default.
• W2070089477 hasAuthorship W2070089477A5044622003 @default.
• W2070089477 hasAuthorship W2070089477A5048394640 @default.
• W2070089477 hasAuthorship W2070089477A5061988106 @default.
• W2070089477 hasAuthorship W2070089477A5063428489 @default.
• W2070089477 hasBestOaLocation W20700894771 @default.
• W2070089477 hasConcept C104317684 @default.
• W2070089477 hasConcept C109825262 @default.
• W2070089477 hasConcept C121608353 @default.
• W2070089477 hasConcept C126322002 @default.
• W2070089477 hasConcept C134305767 @default.
• W2070089477 hasConcept C13514818 @default.
• W2070089477 hasConcept C142724271 @default.
• W2070089477 hasConcept C143589142 @default.
• W2070089477 hasConcept C143998085 @default.
• W2070089477 hasConcept C180754005 @default.
• W2070089477 hasConcept C2781399356 @default.
• W2070089477 hasConcept C501734568 @default.
• W2070089477 hasConcept C502942594 @default.
• W2070089477 hasConcept C54355233 @default.
• W2070089477 hasConcept C555283112 @default.
• W2070089477 hasConcept C71924100 @default.
• W2070089477 hasConcept C86803240 @default.
• W2070089477 hasConceptScore W2070089477C104317684 @default.
• W2070089477 hasConceptScore W2070089477C109825262 @default.
• W2070089477 hasConceptScore W2070089477C121608353 @default.
• W2070089477 hasConceptScore W2070089477C126322002 @default.
• W2070089477 hasConceptScore W2070089477C134305767 @default.
• W2070089477 hasConceptScore W2070089477C13514818 @default.
• W2070089477 hasConceptScore W2070089477C142724271 @default.
• W2070089477 hasConceptScore W2070089477C143589142 @default.
• W2070089477 hasConceptScore W2070089477C143998085 @default.
• W2070089477 hasConceptScore W2070089477C180754005 @default.
• W2070089477 hasConceptScore W2070089477C2781399356 @default.
• W2070089477 hasConceptScore W2070089477C501734568 @default.
• W2070089477 hasConceptScore W2070089477C502942594 @default.
• W2070089477 hasConceptScore W2070089477C54355233 @default.
• W2070089477 hasConceptScore W2070089477C555283112 @default.
• W2070089477 hasConceptScore W2070089477C71924100 @default.
• W2070089477 hasConceptScore W2070089477C86803240 @default.
• W2070089477 hasIssue "1" @default.
• W2070089477 hasLocation W20700894771 @default.
• W2070089477 hasLocation W20700894772 @default.
• W2070089477 hasLocation W20700894773 @default.
• W2070089477 hasOpenAccess W2070089477 @default.
• W2070089477 hasPrimaryLocation W20700894771 @default.
• W2070089477 hasRelatedWork W1970798969 @default.

• next