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• W2070108439 abstract "Objective Hypertension frequently requires combination therapy to attain efficient control and to prevent cardiovascular diseases effectively. This study was conducted to determine which combination treatment is better in improving vascular damage and BP controlling. Methods 256 elderly patients with essential hypertension were randomly assigned to receive combination of amlodipine and aminoacridine (A group) or combination of amlodipine and telmisartan (B group) for 12 months. Pulse-wave velocity [PWV] and ankle–brachial pressure index [ABI], intima–media thickness (IMT) of carotid arteries were determined before and 12 months after the start of treatments. Results PWV values after 12 months of treatment in two groups were significantly decreased compared to previous values (1,840 +/− 332 cm/s to 1,652 +/− 315 cm/s, P<.001 A group; 1,851 +/− 353 cm/s to 1,492 +/− 349 cm/s, P<.001, B group), whereas ABI values and IMT were unchanged. After 12 months, mean (SD) SBP and DBP were significantly decreased from baseline in both groups (P<.001). The changes in blood pressure at month 12 did not differ significantly between the two groups. In addition, there were significantly different changes in PWV between the two groups (P<.05). Reduction in PWV by B group correlated significantly only with reduction in DBP (P<.05) and remained significant even after controlling for reduction in DBP. Reduction in PWV by A group was not independent of reduction in BP. Conclusions These results showed that treatment with combination of amlodipine and aminoacridine or combination of amlodipine and telmisartan functionally improves the stiffened arteries of elderly patients with essential hypertension, whereas treatment with combination of amlodipine and telmisartan is to be independent of its effects on BPs. Objective Hypertension frequently requires combination therapy to attain efficient control and to prevent cardiovascular diseases effectively. This study was conducted to determine which combination treatment is better in improving vascular damage and BP controlling. Methods 256 elderly patients with essential hypertension were randomly assigned to receive combination of amlodipine and aminoacridine (A group) or combination of amlodipine and telmisartan (B group) for 12 months. Pulse-wave velocity [PWV] and ankle–brachial pressure index [ABI], intima–media thickness (IMT) of carotid arteries were determined before and 12 months after the start of treatments. Results PWV values after 12 months of treatment in two groups were significantly decreased compared to previous values (1,840 +/− 332 cm/s to 1,652 +/− 315 cm/s, P<.001 A group; 1,851 +/− 353 cm/s to 1,492 +/− 349 cm/s, P<.001, B group), whereas ABI values and IMT were unchanged. After 12 months, mean (SD) SBP and DBP were significantly decreased from baseline in both groups (P<.001). The changes in blood pressure at month 12 did not differ significantly between the two groups. In addition, there were significantly different changes in PWV between the two groups (P<.05). Reduction in PWV by B group correlated significantly only with reduction in DBP (P<.05) and remained significant even after controlling for reduction in DBP. Reduction in PWV by A group was not independent of reduction in BP. Conclusions These results showed that treatment with combination of amlodipine and aminoacridine or combination of amlodipine and telmisartan functionally improves the stiffened arteries of elderly patients with essential hypertension, whereas treatment with combination of amlodipine and telmisartan is to be independent of its effects on BPs." @default.
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• W2070108439 date "2009-10-01" @default.
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• W2070108439 title "Effects of combination of amlodipine and aminoacridine or telmisartan anti-hypertension and in improving arterial stiffness in elderly patients with essential hypertension" @default.
• W2070108439 doi "https://doi.org/10.1016/j.ijcard.2009.09.328" @default.
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