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• W2070109729 abstract "Type 2 diabetes, which accounts for 90-95% of all cases of diabetes, is a growing epidemic that places a severe burden on health care systems, especially in developing countries. Because of both the scale of the problem and the current epidemic growth of diabetes, it is a priority to find new approaches to better understand and treat this disease. Gastrointestinal surgery may provide new opportunities in the fight against diabetes. Conventional gastrointestinal operations for morbid obesity have been shown to dramatically improve type 2 diabetes, resulting in normal blood glucose and glycosylated hemoglobin levels, with discontinuation of all diabetes-related medications. Return to euglycemia and normal insulin levels are observed within days after surgery, suggesting that weight loss alone cannot entirely explain why surgery improves diabetes. Recent experimental studies point toward the rearrangement of gastrointestinal anatomy as a primary mediator of the surgical control of diabetes, suggesting a role of the small bowel in the pathophysiology of the disease. This article presents available evidence in support of the hypothesis that type 2 diabetes may be an operable disease characterized by a component of intestinal dysfunction." @default.
• W2070109729 created "2016-06-24" @default.
• W2070109729 creator A5015829737 @default.
• W2070109729 date "2008-02-01" @default.
• W2070109729 modified "2023-10-15" @default.
• W2070109729 title "Is Type 2 Diabetes an Operable Intestinal Disease?" @default.
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• W2070109729 doi "https://doi.org/10.2337/dc08-s271" @default.
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