FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070115283> ?p ?o ?g. }

• W2070115283 endingPage "11079" @default.
• W2070115283 startingPage "11074" @default.
• W2070115283 abstract "Tuberous sclerosis (TSC) is an autosomally dominant neurocutaneous disease notable for its high comorbidity with autism in human patients. Studies of murine models of tuberous sclerosis have found defects in cognition and learning, but thus far have not uncovered deficits in social behaviors relevant to autism. To explore social communication and interaction in TSC2 heterozygous mice, we recorded ultrasonic vocalizations (USV) and found that although both wild-type (WT) and heterozygous pups born to WT dams showed similar call rates and patterns, baseline vocalization rates were elevated in pups born to heterozygous dams. Further analysis revealed several robust features of maternal potentiation in all but WT pups born to heterozygous dams. This lack of potentiation is suggestive of defects in mother–pup social interaction during or before the reunion period between WT pups and heterozygous dams. Intriguingly, male pups of both genotypes born to heterozygous dams showed particularly heightened call rates and burst patterns. Because our maternal retrieval experiments revealed that TSC2 +/− dams exhibited improved defensive reactions against intruders and highly efficient pup retrieval performance, the alterations in their pups’ USVs and maternal potentiation do not appear to result from poor maternal care. These findings suggest that a pup's interaction with its mother strongly influences the pup's vocal communication, revealing an intriguing dependence of this social behavior on TSC2 gene dosage of both parties involved. Our study of this murine model thus uncovers social abnormalities that arise from TSC haploinsufficiency and are suggestive of autism." @default.
• W2070115283 created "2016-06-24" @default.
• W2070115283 creator A5037141307 @default.
• W2070115283 creator A5041305380 @default.
• W2070115283 creator A5066421476 @default.
• W2070115283 creator A5088929865 @default.
• W2070115283 date "2010-06-01" @default.
• W2070115283 modified "2023-10-05" @default.
• W2070115283 title "Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism" @default.
• W2070115283 cites W1545137587 @default.
• W2070115283 cites W1581893277 @default.
• W2070115283 cites W1965065820 @default.
• W2070115283 cites W1974726084 @default.
• W2070115283 cites W1981366587 @default.
• W2070115283 cites W1983867657 @default.
• W2070115283 cites W1989779456 @default.
• W2070115283 cites W1992946532 @default.
• W2070115283 cites W1995456557 @default.
• W2070115283 cites W2006296034 @default.
• W2070115283 cites W2014102714 @default.
• W2070115283 cites W2024866859 @default.
• W2070115283 cites W2028834304 @default.
• W2070115283 cites W2029810183 @default.
• W2070115283 cites W2034728437 @default.
• W2070115283 cites W2035212224 @default.
• W2070115283 cites W2044748977 @default.
• W2070115283 cites W2045723788 @default.
• W2070115283 cites W2053434663 @default.
• W2070115283 cites W2069499439 @default.
• W2070115283 cites W2099464916 @default.
• W2070115283 cites W2129381979 @default.
• W2070115283 cites W2129910485 @default.
• W2070115283 cites W2134138119 @default.
• W2070115283 cites W2153617971 @default.
• W2070115283 cites W2160242809 @default.
• W2070115283 cites W2162203550 @default.
• W2070115283 cites W4211261982 @default.
• W2070115283 cites W4386007749 @default.
• W2070115283 cites W80780854 @default.
• W2070115283 doi "https://doi.org/10.1073/pnas.1005620107" @default.
• W2070115283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890736" @default.
• W2070115283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20534473" @default.
• W2070115283 hasPublicationYear "2010" @default.
• W2070115283 type Work @default.
• W2070115283 sameAs 2070115283 @default.
• W2070115283 citedByCount "124" @default.
• W2070115283 countsByYear W20701152832012 @default.
• W2070115283 countsByYear W20701152832013 @default.
• W2070115283 countsByYear W20701152832014 @default.
• W2070115283 countsByYear W20701152832015 @default.
• W2070115283 countsByYear W20701152832016 @default.
• W2070115283 countsByYear W20701152832017 @default.
• W2070115283 countsByYear W20701152832018 @default.
• W2070115283 countsByYear W20701152832019 @default.
• W2070115283 countsByYear W20701152832020 @default.
• W2070115283 countsByYear W20701152832021 @default.
• W2070115283 countsByYear W20701152832022 @default.
• W2070115283 countsByYear W20701152832023 @default.
• W2070115283 crossrefType "journal-article" @default.
• W2070115283 hasAuthorship W2070115283A5037141307 @default.
• W2070115283 hasAuthorship W2070115283A5041305380 @default.
• W2070115283 hasAuthorship W2070115283A5066421476 @default.
• W2070115283 hasAuthorship W2070115283A5088929865 @default.
• W2070115283 hasBestOaLocation W20701152831 @default.
• W2070115283 hasConcept C104317684 @default.
• W2070115283 hasConcept C118552586 @default.
• W2070115283 hasConcept C127716648 @default.
• W2070115283 hasConcept C138496976 @default.
• W2070115283 hasConcept C153471976 @default.
• W2070115283 hasConcept C15744967 @default.
• W2070115283 hasConcept C170493617 @default.
• W2070115283 hasConcept C180754005 @default.
• W2070115283 hasConcept C205778803 @default.
• W2070115283 hasConcept C25274449 @default.
• W2070115283 hasConcept C2778980267 @default.
• W2070115283 hasConcept C2779422105 @default.
• W2070115283 hasConcept C42407357 @default.
• W2070115283 hasConcept C54355233 @default.
• W2070115283 hasConcept C62478195 @default.
• W2070115283 hasConcept C68838962 @default.
• W2070115283 hasConcept C86554907 @default.
• W2070115283 hasConcept C86803240 @default.
• W2070115283 hasConceptScore W2070115283C104317684 @default.
• W2070115283 hasConceptScore W2070115283C118552586 @default.
• W2070115283 hasConceptScore W2070115283C127716648 @default.
• W2070115283 hasConceptScore W2070115283C138496976 @default.
• W2070115283 hasConceptScore W2070115283C153471976 @default.
• W2070115283 hasConceptScore W2070115283C15744967 @default.
• W2070115283 hasConceptScore W2070115283C170493617 @default.
• W2070115283 hasConceptScore W2070115283C180754005 @default.
• W2070115283 hasConceptScore W2070115283C205778803 @default.
• W2070115283 hasConceptScore W2070115283C25274449 @default.
• W2070115283 hasConceptScore W2070115283C2778980267 @default.
• W2070115283 hasConceptScore W2070115283C2779422105 @default.
• W2070115283 hasConceptScore W2070115283C42407357 @default.
• W2070115283 hasConceptScore W2070115283C54355233 @default.
• W2070115283 hasConceptScore W2070115283C62478195 @default.
• W2070115283 hasConceptScore W2070115283C68838962 @default.

• next