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- W2070128052 abstract "The activation mechanism of G protein-coupled receptors has presented a puzzle that finally may be close to solution. These receptors have a relatively simple architecture consisting of seven transmembrane helices that contain just a handful of highly conserved amino acids, yet they respond to light and a range of chemically diverse ligands. Recent NMR structural studies on the active metarhodopsin II intermediate of the visual receptor rhodopsin, along with the recent crystal structure of the apoprotein opsin, have revealed multiple structural elements or 'switches' that must be simultaneously triggered to achieve full activation. The confluence of several required structural changes is an example of coincidence counting, which is often used by nature to regulate biological processes. In ligand-activated G protein-coupled receptors, the presence of multiple switches may provide an explanation for the differences between full, partial and inverse agonists." @default.
- W2070128052 created "2016-06-24" @default.
- W2070128052 creator A5005439938 @default.
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- W2070128052 date "2009-09-01" @default.
- W2070128052 modified "2023-10-17" @default.
- W2070128052 title "Multiple Switches in G Protein-Coupled Receptor Activation" @default.
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- W2070128052 doi "https://doi.org/10.1016/j.tips.2009.06.003" @default.
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