FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070133063> ?p ?o ?g. }

• W2070133063 endingPage "42" @default.
• W2070133063 startingPage "29" @default.
• W2070133063 abstract "The purpose of this study was to elucidate likely signal transduction pathways in activated bovine neutrophils, by comparing the effects of various inhibitors on the bovine neutrophil respiratory burst and degranulation in vitro. The protein kinase C(PKC) inhibitors staurosporine, and chelerythine, and the beta-adrenergic receptor antagonist DL-propranolol, markedly inhibited opsonized zymosan (OZ) stimulated luminol-dependent chemiluminescence (LDCL). The G-protein inhibitor pertussis toxin (PT), the protein tyrosine inhibitor genistein, and the calcium channel blocker verapamil also reduced LDCL in a dose-dependent manner. In contrast, the lipoxygenase inhibitor zileuton had only a slight effect, and the cyclooxygenase inhibitor indomethacin had no effect on LDCL. The effects of these inhibitors on degranulation was also examined. Staurosporine, propranolol, and pertussis toxin significantly decreased primary granule (beta-glucosaminidase) release in response to OZ. These inhibitors also significantly reduced both phorbol myristate acetate (PMA)-induced primary and secondary granule (lactoferrin) release. Regulation of secondary granule (lactoferrin) release was complex, as it was significantly depressed by propranolol, enhanced by PT and unaffected by staurosporine. These findings suggest that PKC, beta-adrenergic receptors, G-proteins, protein tyrosine kinase(s) and Ca(2+) uptake, may all be involved in some part of the process of bovine neutrophil activation. Moreover, stimulation of LDCL and degranulation may be mediated through distinct signal transduction pathways." @default.
• W2070133063 created "2016-06-24" @default.
• W2070133063 creator A5042611019 @default.
• W2070133063 creator A5057148322 @default.
• W2070133063 date "1996-03-01" @default.
• W2070133063 modified "2023-10-14" @default.
• W2070133063 title "Regulation of luminol-dependent chemiluminescence and degranulation by bovine neutrophils stimulated with opsonized zymosan" @default.
• W2070133063 cites W1491708792 @default.
• W2070133063 cites W1514367439 @default.
• W2070133063 cites W1559915299 @default.
• W2070133063 cites W1573552209 @default.
• W2070133063 cites W1861921958 @default.
• W2070133063 cites W1970895296 @default.
• W2070133063 cites W1983724323 @default.
• W2070133063 cites W1986107507 @default.
• W2070133063 cites W1993762331 @default.
• W2070133063 cites W2008236339 @default.
• W2070133063 cites W2014832613 @default.
• W2070133063 cites W2029841670 @default.
• W2070133063 cites W2035619818 @default.
• W2070133063 cites W2037128614 @default.
• W2070133063 cites W2049856962 @default.
• W2070133063 cites W2060426330 @default.
• W2070133063 cites W2060885622 @default.
• W2070133063 cites W2061606516 @default.
• W2070133063 cites W2062657900 @default.
• W2070133063 cites W2072256028 @default.
• W2070133063 cites W2078270196 @default.
• W2070133063 cites W2083453155 @default.
• W2070133063 cites W2085547973 @default.
• W2070133063 cites W2092020175 @default.
• W2070133063 cites W2121243970 @default.
• W2070133063 cites W2181459194 @default.
• W2070133063 cites W2183893427 @default.
• W2070133063 cites W2333950786 @default.
• W2070133063 cites W2334955217 @default.
• W2070133063 cites W2337579403 @default.
• W2070133063 cites W2337738982 @default.
• W2070133063 cites W2431006461 @default.
• W2070133063 cites W47709512 @default.
• W2070133063 doi "https://doi.org/10.1016/0165-2427(95)05485-5" @default.
• W2070133063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9157684" @default.
• W2070133063 hasPublicationYear "1996" @default.
• W2070133063 type Work @default.
• W2070133063 sameAs 2070133063 @default.
• W2070133063 citedByCount "18" @default.
• W2070133063 countsByYear W20701330632015 @default.
• W2070133063 crossrefType "journal-article" @default.
• W2070133063 hasAuthorship W2070133063A5042611019 @default.
• W2070133063 hasAuthorship W2070133063A5057148322 @default.
• W2070133063 hasConcept C126322002 @default.
• W2070133063 hasConcept C134018914 @default.
• W2070133063 hasConcept C153911025 @default.
• W2070133063 hasConcept C170493617 @default.
• W2070133063 hasConcept C184235292 @default.
• W2070133063 hasConcept C195794163 @default.
• W2070133063 hasConcept C202751555 @default.
• W2070133063 hasConcept C2778870864 @default.
• W2070133063 hasConcept C2779084600 @default.
• W2070133063 hasConcept C2780043322 @default.
• W2070133063 hasConcept C49773422 @default.
• W2070133063 hasConcept C49802076 @default.
• W2070133063 hasConcept C55493867 @default.
• W2070133063 hasConcept C62478195 @default.
• W2070133063 hasConcept C71924100 @default.
• W2070133063 hasConcept C80631254 @default.
• W2070133063 hasConcept C86803240 @default.
• W2070133063 hasConcept C97029542 @default.
• W2070133063 hasConcept C98274493 @default.
• W2070133063 hasConceptScore W2070133063C126322002 @default.
• W2070133063 hasConceptScore W2070133063C134018914 @default.
• W2070133063 hasConceptScore W2070133063C153911025 @default.
• W2070133063 hasConceptScore W2070133063C170493617 @default.
• W2070133063 hasConceptScore W2070133063C184235292 @default.
• W2070133063 hasConceptScore W2070133063C195794163 @default.
• W2070133063 hasConceptScore W2070133063C202751555 @default.
• W2070133063 hasConceptScore W2070133063C2778870864 @default.
• W2070133063 hasConceptScore W2070133063C2779084600 @default.
• W2070133063 hasConceptScore W2070133063C2780043322 @default.
• W2070133063 hasConceptScore W2070133063C49773422 @default.
• W2070133063 hasConceptScore W2070133063C49802076 @default.
• W2070133063 hasConceptScore W2070133063C55493867 @default.
• W2070133063 hasConceptScore W2070133063C62478195 @default.
• W2070133063 hasConceptScore W2070133063C71924100 @default.
• W2070133063 hasConceptScore W2070133063C80631254 @default.
• W2070133063 hasConceptScore W2070133063C86803240 @default.
• W2070133063 hasConceptScore W2070133063C97029542 @default.
• W2070133063 hasConceptScore W2070133063C98274493 @default.
• W2070133063 hasIssue "1-2" @default.
• W2070133063 hasLocation W20701330631 @default.
• W2070133063 hasLocation W20701330632 @default.
• W2070133063 hasOpenAccess W2070133063 @default.
• W2070133063 hasPrimaryLocation W20701330631 @default.
• W2070133063 hasRelatedWork W1964508588 @default.
• W2070133063 hasRelatedWork W1989732178 @default.
• W2070133063 hasRelatedWork W2015873606 @default.
• W2070133063 hasRelatedWork W2050734598 @default.
• W2070133063 hasRelatedWork W2088777770 @default.

• next