FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070136421> ?p ?o ?g. }

• W2070136421 endingPage "429" @default.
• W2070136421 startingPage "424" @default.
• W2070136421 abstract "The major histocompatibility complex (MHC) region on chromosome 6p21.3 is suspected to host susceptibility loci for HIV-related Kaposi's sarcoma (HIV-KS). A nested case-control study in the Multicenter AIDS Cohort Study was designed to conduct fine genetic association mapping across central MHC. Individuals co-infected with HIV-1 and human herpes virus-8 who later developed KS were defined as cases (n=354) and were matched 1:1 with co-infected KS-free controls. We report data for new independent MHC class II and III susceptibility loci. In particular, class II HLA-DMB emerged as a strong candidate, with the intronic variant rs6902982 A>G associated with a fourfold increase of risk (odds ratio (OR)=4.09; 95% confidence interval (CI)=1.90-8.80; P=0.0003). A striking multiplicative effect on the estimated risk was associated with further carriage of two non-synonymous variants, rs1800453 A>G (Asp697Gly) and rs4148880 A>G (Ile393Val), in the linked TAP1 gene (OR=10.5; 95% CI=2.54-43.6; P=0.0012). The class III susceptibility variant is moderately associated with HIV-KS and lies within a 120-kb-long haplotype (OR=1.52; 95% CI=1.01-2.28; P=0.047) formed by rs7029 A>G (GPANK1 3' untranslated region), rs1065356 G>A (LY6G6C), rs3749953 A>G (MSH5-SAPCD1 read through) and rs707926 G>A (VARS). Our data suggest that antigen processing by MHC class II molecules is a target pathway in the pathogenesis of HIV-KS." @default.
• W2070136421 created "2016-06-24" @default.
• W2070136421 creator A5035161117 @default.
• W2070136421 creator A5038573016 @default.
• W2070136421 creator A5068578553 @default.
• W2070136421 creator A5071063677 @default.
• W2070136421 creator A5075524664 @default.
• W2070136421 creator A5075967215 @default.
• W2070136421 date "2014-07-10" @default.
• W2070136421 modified "2023-09-27" @default.
• W2070136421 title "SNP screening of central MHC-identified HLA-DMB as a candidate susceptibility gene for HIV-related Kaposi’s sarcoma" @default.
• W2070136421 cites W1492343766 @default.
• W2070136421 cites W1520790482 @default.
• W2070136421 cites W1984899257 @default.
• W2070136421 cites W1985106018 @default.
• W2070136421 cites W1987852476 @default.
• W2070136421 cites W1989011018 @default.
• W2070136421 cites W2012535996 @default.
• W2070136421 cites W2021218886 @default.
• W2070136421 cites W2023718204 @default.
• W2070136421 cites W2032438721 @default.
• W2070136421 cites W2033092968 @default.
• W2070136421 cites W2041769222 @default.
• W2070136421 cites W2062265566 @default.
• W2070136421 cites W2063999310 @default.
• W2070136421 cites W2070127549 @default.
• W2070136421 cites W2084607178 @default.
• W2070136421 cites W2095645580 @default.
• W2070136421 cites W2107141980 @default.
• W2070136421 cites W2131940574 @default.
• W2070136421 cites W2137472196 @default.
• W2070136421 cites W2145813884 @default.
• W2070136421 cites W2164433153 @default.
• W2070136421 cites W2165667820 @default.
• W2070136421 cites W2168308593 @default.
• W2070136421 cites W2170821252 @default.
• W2070136421 cites W4235116950 @default.
• W2070136421 doi "https://doi.org/10.1038/gene.2014.42" @default.
• W2070136421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4174341" @default.
• W2070136421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25008864" @default.
• W2070136421 hasPublicationYear "2014" @default.
• W2070136421 type Work @default.
• W2070136421 sameAs 2070136421 @default.
• W2070136421 citedByCount "18" @default.
• W2070136421 countsByYear W20701364212015 @default.
• W2070136421 countsByYear W20701364212016 @default.
• W2070136421 countsByYear W20701364212018 @default.
• W2070136421 countsByYear W20701364212019 @default.
• W2070136421 countsByYear W20701364212020 @default.
• W2070136421 countsByYear W20701364212021 @default.
• W2070136421 countsByYear W20701364212022 @default.
• W2070136421 countsByYear W20701364212023 @default.
• W2070136421 crossrefType "journal-article" @default.
• W2070136421 hasAuthorship W2070136421A5035161117 @default.
• W2070136421 hasAuthorship W2070136421A5038573016 @default.
• W2070136421 hasAuthorship W2070136421A5068578553 @default.
• W2070136421 hasAuthorship W2070136421A5071063677 @default.
• W2070136421 hasAuthorship W2070136421A5075524664 @default.
• W2070136421 hasAuthorship W2070136421A5075967215 @default.
• W2070136421 hasBestOaLocation W20701364211 @default.
• W2070136421 hasConcept C104317684 @default.
• W2070136421 hasConcept C126322002 @default.
• W2070136421 hasConcept C135763542 @default.
• W2070136421 hasConcept C139275648 @default.
• W2070136421 hasConcept C147483822 @default.
• W2070136421 hasConcept C153209595 @default.
• W2070136421 hasConcept C156957248 @default.
• W2070136421 hasConcept C159047783 @default.
• W2070136421 hasConcept C170627219 @default.
• W2070136421 hasConcept C188280979 @default.
• W2070136421 hasConcept C197754878 @default.
• W2070136421 hasConcept C203014093 @default.
• W2070136421 hasConcept C207936829 @default.
• W2070136421 hasConcept C2522874641 @default.
• W2070136421 hasConcept C2776452011 @default.
• W2070136421 hasConcept C2779898580 @default.
• W2070136421 hasConcept C2780727368 @default.
• W2070136421 hasConcept C54355233 @default.
• W2070136421 hasConcept C69991583 @default.
• W2070136421 hasConcept C71924100 @default.
• W2070136421 hasConcept C86803240 @default.
• W2070136421 hasConceptScore W2070136421C104317684 @default.
• W2070136421 hasConceptScore W2070136421C126322002 @default.
• W2070136421 hasConceptScore W2070136421C135763542 @default.
• W2070136421 hasConceptScore W2070136421C139275648 @default.
• W2070136421 hasConceptScore W2070136421C147483822 @default.
• W2070136421 hasConceptScore W2070136421C153209595 @default.
• W2070136421 hasConceptScore W2070136421C156957248 @default.
• W2070136421 hasConceptScore W2070136421C159047783 @default.
• W2070136421 hasConceptScore W2070136421C170627219 @default.
• W2070136421 hasConceptScore W2070136421C188280979 @default.
• W2070136421 hasConceptScore W2070136421C197754878 @default.
• W2070136421 hasConceptScore W2070136421C203014093 @default.
• W2070136421 hasConceptScore W2070136421C207936829 @default.
• W2070136421 hasConceptScore W2070136421C2522874641 @default.
• W2070136421 hasConceptScore W2070136421C2776452011 @default.
• W2070136421 hasConceptScore W2070136421C2779898580 @default.
• W2070136421 hasConceptScore W2070136421C2780727368 @default.

• next