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• W2070136620 abstract "Abstract Creatine kinase (CK)‐catalysed ATP–phosphocreatine (PCr) exchange is considered to play a key role in energy homeostasis of the brain. This study assessed the metabolic and anatomical consequences of partial or complete depletion of this system in transgenic mice without cytosolic B‐CK (B‐CK–/–), mitochondrial ubiquitous CK (UbCKmit–/–), or both isoenzymes (CK –/–), using non‐invasive quantitative magnetic resonance (MR) imaging and spectroscopy. MR imaging revealed an increase in ventricle size in a subset of B‐CK–/– mice, but not in animals with UbCKmit or compound CK mutations. Mice lacking single CK isoenzymes had normal levels of high‐energy metabolites and tissue pH. In the brains of CK double knockouts pH and ATP and Pi levels were also normal, even though PCr had become completely undetectable. Moreover, a 20–30% decrease was observed in the level of total creatine and a similar increase in the level of neuronal N ‐acetyl‐aspartate compounds. Although CKs themselves are not evenly distributed throughout the CNS, these alterations were uniform and concordant across different brain regions. Changes in myo ‐inositol and glutamate peaks did appear to be mutation type and brain area specific. Our results challenge current models for the biological significance of the PCr–CK energy system and suggest a multifaceted role for creatine in the brain." @default.
• W2070136620 created "2016-06-24" @default.
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• W2070136620 date "2004-08-16" @default.
• W2070136620 modified "2023-10-10" @default.
• W2070136620 title "Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: a quantitative in vivo1H and 31P magnetic resonance study" @default.
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• W2070136620 doi "https://doi.org/10.1111/j.1471-4159.2004.02599.x" @default.
• W2070136620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15341516" @default.
• W2070136620 hasPublicationYear "2004" @default.
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