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- W20701370 endingPage "166" @default.
- W20701370 startingPage "133" @default.
- W20701370 abstract "The first part of this chapter is dedicated to nonredox metabolic reactions of functionalization (phase I), in other words reactions of hydrolysis. The innumerable hydrolases known or suspected to act on drugs and other xenobiotics are summarized. This is followed by a short review of the substrates of these hydrolases, namely esters, amides, and peptides, with a number of medicinally relevant examples selected for discussion. Epoxide hydrolases are considered next together with their substrates, namely arene oxides and alkene oxides. The major part of the chapter covers conjugation (phase II) reactions. First, criteria are defined that characterize metabolic reactions of conjugation. Discussed here are major and lesser reactions of conjugation, namely methylation, sulfation, phosphorylation, glucuronidation, acetylation, and glutathione conjugation. A special section is dedicated to the conjugation of foreign carboxylic acids to coenzyme A and to the various secondary pathways open to such acyl-CoA conjugates, namely amino acid conjugation, formation of hybrid triglycerides and cholesteryl esters, β-oxidation, and the chiral inversion of profens. For all reactions of conjugation, the emphasis is first on the enzymes involved (transferases), then on their target groups and substrates. The chapter ends with a brief discussion pointing to some analogies and differences between phase I and II reactions." @default.
- W20701370 created "2016-06-24" @default.
- W20701370 creator A5080796605 @default.
- W20701370 date "2007-01-01" @default.
- W20701370 modified "2023-10-07" @default.
- W20701370 title "Principles of Drug Metabolism 2: Hydrolysis and Conjugation Reactions" @default.
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