FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070137904> ?p ?o ?g. }

• W2070137904 endingPage "2462" @default.
• W2070137904 startingPage "2454" @default.
• W2070137904 abstract "SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cells. SAMHD1 mutations cause autoimmune Aicardi-Goutières syndrome and are found in cancers including chronic lymphocytic leukaemia. SAMHD1 is a triphosphohydrolase that depletes the cellular pool of deoxynucleoside triphosphates, thereby preventing reverse transcription of retroviral genomes. However, in vivo evidence for SAMHD1's antiviral activity has been lacking. We generated Samhd1 null mice that do not develop autoimmune disease despite displaying a type I interferon signature in spleen, macrophages and fibroblasts. Samhd1(-/-) cells have elevated deoxynucleoside triphosphate (dNTP) levels but, surprisingly, SAMHD1 deficiency did not lead to increased infection with VSV-G-pseudotyped HIV-1 vectors. The lack of restriction is likely attributable to the fact that dNTP concentrations in SAMHD1-sufficient mouse cells are higher than the KM of HIV-1 reverse transcriptase (RT). Consistent with this notion, an HIV-1 vector mutant bearing an RT with lower affinity for dNTPs was sensitive to SAMHD1-dependent restriction in cultured cells and in mice. This shows that SAMHD1 can restrict lentiviruses in vivo and that nucleotide starvation is an evolutionarily conserved antiviral mechanism." @default.
• W2070137904 created "2016-06-24" @default.
• W2070137904 creator A5008230485 @default.
• W2070137904 creator A5013758087 @default.
• W2070137904 creator A5038336747 @default.
• W2070137904 creator A5039240766 @default.
• W2070137904 creator A5043068924 @default.
• W2070137904 creator A5052252634 @default.
• W2070137904 creator A5053636210 @default.
• W2070137904 creator A5054255908 @default.
• W2070137904 creator A5055046444 @default.
• W2070137904 creator A5062505896 @default.
• W2070137904 creator A5078937992 @default.
• W2070137904 creator A5080842218 @default.
• W2070137904 date "2013-07-19" @default.
• W2070137904 modified "2023-09-23" @default.
• W2070137904 title "SAMHD1-dependent retroviral control and escape in mice" @default.
• W2070137904 cites W1964567249 @default.
• W2070137904 cites W1966903977 @default.
• W2070137904 cites W1975031262 @default.
• W2070137904 cites W1982410222 @default.
• W2070137904 cites W1983711023 @default.
• W2070137904 cites W1987480613 @default.
• W2070137904 cites W1992007798 @default.
• W2070137904 cites W2000195190 @default.
• W2070137904 cites W2000918346 @default.
• W2070137904 cites W2003789674 @default.
• W2070137904 cites W2008892095 @default.
• W2070137904 cites W2017760549 @default.
• W2070137904 cites W2019039109 @default.
• W2070137904 cites W2019388385 @default.
• W2070137904 cites W2021736427 @default.
• W2070137904 cites W2027246028 @default.
• W2070137904 cites W2027853473 @default.
• W2070137904 cites W2031476529 @default.
• W2070137904 cites W2035743151 @default.
• W2070137904 cites W2042386784 @default.
• W2070137904 cites W2045628835 @default.
• W2070137904 cites W2061850853 @default.
• W2070137904 cites W2063855257 @default.
• W2070137904 cites W2066106215 @default.
• W2070137904 cites W2069554621 @default.
• W2070137904 cites W2078786014 @default.
• W2070137904 cites W2085318117 @default.
• W2070137904 cites W2088580309 @default.
• W2070137904 cites W2097121543 @default.
• W2070137904 cites W2101507032 @default.
• W2070137904 cites W2104574305 @default.
• W2070137904 cites W2105819314 @default.
• W2070137904 cites W2111969980 @default.
• W2070137904 cites W2116778443 @default.
• W2070137904 cites W2128211133 @default.
• W2070137904 cites W2138933731 @default.
• W2070137904 cites W2142759365 @default.
• W2070137904 cites W2144623444 @default.
• W2070137904 cites W2145812105 @default.
• W2070137904 cites W2147264814 @default.
• W2070137904 cites W2148351505 @default.
• W2070137904 cites W2154792934 @default.
• W2070137904 cites W2155139766 @default.
• W2070137904 cites W2167317609 @default.
• W2070137904 cites W2262414037 @default.
• W2070137904 cites W4240753862 @default.
• W2070137904 doi "https://doi.org/10.1038/emboj.2013.163" @default.
• W2070137904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3770946" @default.
• W2070137904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23872947" @default.
• W2070137904 hasPublicationYear "2013" @default.
• W2070137904 type Work @default.
• W2070137904 sameAs 2070137904 @default.
• W2070137904 citedByCount "133" @default.
• W2070137904 countsByYear W20701379042013 @default.
• W2070137904 countsByYear W20701379042014 @default.
• W2070137904 countsByYear W20701379042015 @default.
• W2070137904 countsByYear W20701379042016 @default.
• W2070137904 countsByYear W20701379042017 @default.
• W2070137904 countsByYear W20701379042018 @default.
• W2070137904 countsByYear W20701379042019 @default.
• W2070137904 countsByYear W20701379042020 @default.
• W2070137904 countsByYear W20701379042021 @default.
• W2070137904 countsByYear W20701379042022 @default.
• W2070137904 countsByYear W20701379042023 @default.
• W2070137904 crossrefType "journal-article" @default.
• W2070137904 hasAuthorship W2070137904A5008230485 @default.
• W2070137904 hasAuthorship W2070137904A5013758087 @default.
• W2070137904 hasAuthorship W2070137904A5038336747 @default.
• W2070137904 hasAuthorship W2070137904A5039240766 @default.
• W2070137904 hasAuthorship W2070137904A5043068924 @default.
• W2070137904 hasAuthorship W2070137904A5052252634 @default.
• W2070137904 hasAuthorship W2070137904A5053636210 @default.
• W2070137904 hasAuthorship W2070137904A5054255908 @default.
• W2070137904 hasAuthorship W2070137904A5055046444 @default.
• W2070137904 hasAuthorship W2070137904A5062505896 @default.
• W2070137904 hasAuthorship W2070137904A5078937992 @default.
• W2070137904 hasAuthorship W2070137904A5080842218 @default.
• W2070137904 hasBestOaLocation W20701379042 @default.
• W2070137904 hasConcept C104317684 @default.
• W2070137904 hasConcept C143065580 @default.
• W2070137904 hasConcept C153911025 @default.

• next