Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070143629> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2070143629 endingPage "1784" @default.
- W2070143629 startingPage "1779" @default.
- W2070143629 abstract "Although enzyme-hydrolyzed silk fibroin has been reported to enhance cognitive function before, it has been still unknown which peptides can improve memory. Here we report that amino acid sequences of three novel peptides were identified from fibroin hydrolysate. Fibroin hydrolysate was obtained by hydrolysis with protease after partial hydrolysis with 5M CaCl2. Synthesized peptides derived from these sequences improved scopolamine-induced memory impairments in mice. We confirmed this hydrolysate had effects that improved learning and memory abilities by performing the Rey-Kim test. From this hydrolysate of silk fibroin, amino acid sequences of eight peptides were identified by LC-MS/MS. Three peptides (GAGAGTGSSGFGPY, GAGAGSGAGSGAGAGSGAGAGY, and SGAGSGAGAGSGAGAGSGA) were synthesized to investigate whether they could improve memory. Passive avoidance test and Morris water maze test were performed, and all peptides showed memory-enhancing abilities on scopolamine-induced memory impairments in mice. In this study, we identified three novel peptides that could improve memory, and that silk fibroin hydrolysate was a mixture of various active peptides that could enhance memory." @default.
- W2070143629 created "2016-06-24" @default.
- W2070143629 creator A5007867229 @default.
- W2070143629 creator A5030458503 @default.
- W2070143629 creator A5039216409 @default.
- W2070143629 creator A5047872140 @default.
- W2070143629 date "2013-12-28" @default.
- W2070143629 modified "2023-09-29" @default.
- W2070143629 title "Memory-Enhancing Effects of Silk Fibroin-Derived Peptides in Scopolamine-Treated Mice" @default.
- W2070143629 cites W1966626818 @default.
- W2070143629 cites W1990717494 @default.
- W2070143629 cites W2004658920 @default.
- W2070143629 cites W2005987631 @default.
- W2070143629 cites W2013912398 @default.
- W2070143629 cites W2026278687 @default.
- W2070143629 cites W2044984549 @default.
- W2070143629 cites W2048455450 @default.
- W2070143629 cites W2056590688 @default.
- W2070143629 cites W2076828256 @default.
- W2070143629 cites W2113007777 @default.
- W2070143629 cites W2158728496 @default.
- W2070143629 cites W2334012401 @default.
- W2070143629 cites W2401671915 @default.
- W2070143629 cites W2520052202 @default.
- W2070143629 cites W2520927805 @default.
- W2070143629 cites W2799379448 @default.
- W2070143629 doi "https://doi.org/10.4014/jmb.1308.08059" @default.
- W2070143629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24043122" @default.
- W2070143629 hasPublicationYear "2013" @default.
- W2070143629 type Work @default.
- W2070143629 sameAs 2070143629 @default.
- W2070143629 citedByCount "13" @default.
- W2070143629 countsByYear W20701436292016 @default.
- W2070143629 countsByYear W20701436292017 @default.
- W2070143629 countsByYear W20701436292018 @default.
- W2070143629 countsByYear W20701436292020 @default.
- W2070143629 countsByYear W20701436292021 @default.
- W2070143629 countsByYear W20701436292022 @default.
- W2070143629 crossrefType "journal-article" @default.
- W2070143629 hasAuthorship W2070143629A5007867229 @default.
- W2070143629 hasAuthorship W2070143629A5030458503 @default.
- W2070143629 hasAuthorship W2070143629A5039216409 @default.
- W2070143629 hasAuthorship W2070143629A5047872140 @default.
- W2070143629 hasBestOaLocation W20701436291 @default.
- W2070143629 hasConcept C122302759 @default.
- W2070143629 hasConcept C159985019 @default.
- W2070143629 hasConcept C185592680 @default.
- W2070143629 hasConcept C192562407 @default.
- W2070143629 hasConcept C206767735 @default.
- W2070143629 hasConcept C2779281246 @default.
- W2070143629 hasConcept C2780431358 @default.
- W2070143629 hasConcept C28800991 @default.
- W2070143629 hasConcept C515207424 @default.
- W2070143629 hasConcept C55493867 @default.
- W2070143629 hasConcept C94412978 @default.
- W2070143629 hasConceptScore W2070143629C122302759 @default.
- W2070143629 hasConceptScore W2070143629C159985019 @default.
- W2070143629 hasConceptScore W2070143629C185592680 @default.
- W2070143629 hasConceptScore W2070143629C192562407 @default.
- W2070143629 hasConceptScore W2070143629C206767735 @default.
- W2070143629 hasConceptScore W2070143629C2779281246 @default.
- W2070143629 hasConceptScore W2070143629C2780431358 @default.
- W2070143629 hasConceptScore W2070143629C28800991 @default.
- W2070143629 hasConceptScore W2070143629C515207424 @default.
- W2070143629 hasConceptScore W2070143629C55493867 @default.
- W2070143629 hasConceptScore W2070143629C94412978 @default.
- W2070143629 hasIssue "12" @default.
- W2070143629 hasLocation W20701436291 @default.
- W2070143629 hasLocation W20701436292 @default.
- W2070143629 hasOpenAccess W2070143629 @default.
- W2070143629 hasPrimaryLocation W20701436291 @default.
- W2070143629 hasRelatedWork W2031688766 @default.
- W2070143629 hasRelatedWork W2141606379 @default.
- W2070143629 hasRelatedWork W2320528171 @default.
- W2070143629 hasRelatedWork W2350584382 @default.
- W2070143629 hasRelatedWork W2371472158 @default.
- W2070143629 hasRelatedWork W2375260602 @default.
- W2070143629 hasRelatedWork W2390593822 @default.
- W2070143629 hasRelatedWork W2941624622 @default.
- W2070143629 hasRelatedWork W3203983557 @default.
- W2070143629 hasRelatedWork W573548917 @default.
- W2070143629 hasVolume "23" @default.
- W2070143629 isParatext "false" @default.
- W2070143629 isRetracted "false" @default.
- W2070143629 magId "2070143629" @default.
- W2070143629 workType "article" @default.