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- W2070144875 abstract "The environmental carcinogens N -nitrosopyrrolidine (NPYR) and N′ -nitrosonornicotine (NNN) were incubated with human liver microsomes to test for the presence of enzymes catalyzing α-hydroxylation, which is likely to be an activation mechanism for these compounds. Both nitrosamines underwent α-hydroxylation; rates were higher for NPYR than for NNN, as observed in rats. The results indicate that both NPYR and NNN can be metabolically activated by human liver microsomes." @default.
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- W2070144875 date "1979-11-01" @default.
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- W2070144875 title "α-Hydroxylation of N-nitrosopyrrolidine and N′-nitrosonornicotine by human liver microsomes" @default.
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- W2070144875 doi "https://doi.org/10.1016/0304-3835(79)90020-x" @default.
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