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- W2070147153 abstract "(BY CABLE.) IN the early days of my investigations in connexion with insulin, I predicted that whenever glycogen occurred in Nature an insulin-like substance would also be found. Putting this theory to the test, I obtained positive results first with clam tissue, and later with yeast. This result was obtained during the latter part of January. In the light of this latter result, my mode of reasoning was changed. If yeast contains an insulin-like hormone, other plants may also contain it. Extracts of tissue of a variety of the higher plants were, therefore, prepared, and the effect of subcutaneous injection of these extracts upon the blood sugar of the normal rabbit was ascertained. The effect of certain plant extracts upon the blood sugar of depancreated dogs was also studied. Extracts made from onion tops, onion roots, barley roots and sprouted grain, green wheat leaves, bean tops, and lettuce were found to produce marked hyperglycaemia in normal rabbits. The day following the administration of an extract of green onion tops to a depancreated dog with a blood sugar of 0.190 per cent., a blood sugar of 0.090 per cent. was observed. The results of this investigation were communicated to the Society for Experimental Biology and Medicine at the meeting in New York City on March 21, when I suggested the name “Glucokinin” for this new plant hormone. Since that date I notice in NATURE of March 10 a letter by Messrs. Winter and Smith stating that they have obtained positive results with yeast extracts. These authors would, therefore, share coincident priority with me in this particular." @default.
- W2070147153 created "2016-06-24" @default.
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- W2070147153 date "1923-04-01" @default.
- W2070147153 modified "2023-09-28" @default.
- W2070147153 title "Effect of Plant Extracts on Blood Sugar" @default.
- W2070147153 doi "https://doi.org/10.1038/111571b0" @default.
- W2070147153 hasPublicationYear "1923" @default.
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