Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070147241> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2070147241 endingPage "306" @default.
- W2070147241 startingPage "298" @default.
- W2070147241 abstract "In order to understand the role of sympatho-adrenomedullary (SAM) system in mediating stress effect on non-specific immune responses in fishes, the splenic macrophage phagocytic and respiratory burst activities of normal and chemically sympathectomized Channa punctatus under restraint stress were studied. Chemical sympathectomy abrogated the differential effects of acute stress on diverse functions of macrophages. The SAM regulation of macrophage activities was substantiated by in vitro experiments with catecholamines, the end product of SAM system. Further, for the first time in fishes, different adrenoceptors and their precise second messenger system regulating diverse functions of macrophages by catecholamines were demonstrated. Norepinephrine (NE)/epinephrine (E) decreased the phagocytosis through beta-adrenergic receptor as only propranolol, the beta-adrenergic receptor antagonist, blocked the suppressive effect of NE/E. However, dopamine (DA) regulates phagocytosis solely via the dopaminergic receptor. The DA effect was mimicked by DA receptor agonists, apomorphine and bromocryptine. Adenylate cyclase system linked to beta-adrenoceptor/dopaminergic receptor seems to be involved in mediating the effect of catecholamine on phagocytosis since db cAMP inhibited the phagocytosis in a dose-dependent manner. In case of superoxide production, only phenoxybenzamine, an alpha-adrenergic receptor antagonist, was seen effective in blocking the stimulatory effect of NE/E. Further, Ca2+ as second messenger system coupled to alpha1-adrenergic receptor was shown to mediate this effect since phospholipase C (PLC) inhibitor, U73122 and intracellular calcium chelating agent, BAPTA-AM downregulated the NE/E-induced superoxide production. The role of calcium in modulation of superoxide production was also emphasized using calcium ionophore A23187." @default.
- W2070147241 created "2016-06-24" @default.
- W2070147241 creator A5032926833 @default.
- W2070147241 creator A5046145756 @default.
- W2070147241 date "2008-01-01" @default.
- W2070147241 modified "2023-09-25" @default.
- W2070147241 title "Role of adrenoceptor-coupled second messenger system in sympatho-adrenomedullary modulation of splenic macrophage functions in live fish Channa punctatus" @default.
- W2070147241 cites W1946129634 @default.
- W2070147241 cites W1966629080 @default.
- W2070147241 cites W1968249667 @default.
- W2070147241 cites W1980139290 @default.
- W2070147241 cites W1988248058 @default.
- W2070147241 cites W2001479170 @default.
- W2070147241 cites W2008679028 @default.
- W2070147241 cites W2016751159 @default.
- W2070147241 cites W2019552715 @default.
- W2070147241 cites W2031335839 @default.
- W2070147241 cites W2037097386 @default.
- W2070147241 cites W2039529214 @default.
- W2070147241 cites W2040883320 @default.
- W2070147241 cites W2043076168 @default.
- W2070147241 cites W2050907042 @default.
- W2070147241 cites W2053855870 @default.
- W2070147241 cites W2055841837 @default.
- W2070147241 cites W2059586870 @default.
- W2070147241 cites W2061743376 @default.
- W2070147241 cites W2063344555 @default.
- W2070147241 cites W2079500751 @default.
- W2070147241 cites W2083585533 @default.
- W2070147241 cites W2095094541 @default.
- W2070147241 cites W2108402828 @default.
- W2070147241 cites W2109811381 @default.
- W2070147241 cites W2130837258 @default.
- W2070147241 cites W2136061619 @default.
- W2070147241 cites W2142072453 @default.
- W2070147241 cites W2150476886 @default.
- W2070147241 cites W2164732799 @default.
- W2070147241 cites W2187292460 @default.
- W2070147241 doi "https://doi.org/10.1016/j.ygcen.2007.05.008" @default.
- W2070147241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17574246" @default.
- W2070147241 hasPublicationYear "2008" @default.
- W2070147241 type Work @default.
- W2070147241 sameAs 2070147241 @default.
- W2070147241 citedByCount "33" @default.
- W2070147241 countsByYear W20701472412012 @default.
- W2070147241 countsByYear W20701472412013 @default.
- W2070147241 countsByYear W20701472412014 @default.
- W2070147241 countsByYear W20701472412015 @default.
- W2070147241 countsByYear W20701472412016 @default.
- W2070147241 countsByYear W20701472412017 @default.
- W2070147241 countsByYear W20701472412018 @default.
- W2070147241 countsByYear W20701472412019 @default.
- W2070147241 countsByYear W20701472412020 @default.
- W2070147241 countsByYear W20701472412021 @default.
- W2070147241 countsByYear W20701472412022 @default.
- W2070147241 crossrefType "journal-article" @default.
- W2070147241 hasAuthorship W2070147241A5032926833 @default.
- W2070147241 hasAuthorship W2070147241A5046145756 @default.
- W2070147241 hasConcept C126322002 @default.
- W2070147241 hasConcept C134018914 @default.
- W2070147241 hasConcept C163235415 @default.
- W2070147241 hasConcept C170493617 @default.
- W2070147241 hasConcept C2776885963 @default.
- W2070147241 hasConcept C2778122271 @default.
- W2070147241 hasConcept C55493867 @default.
- W2070147241 hasConcept C71924100 @default.
- W2070147241 hasConcept C86803240 @default.
- W2070147241 hasConceptScore W2070147241C126322002 @default.
- W2070147241 hasConceptScore W2070147241C134018914 @default.
- W2070147241 hasConceptScore W2070147241C163235415 @default.
- W2070147241 hasConceptScore W2070147241C170493617 @default.
- W2070147241 hasConceptScore W2070147241C2776885963 @default.
- W2070147241 hasConceptScore W2070147241C2778122271 @default.
- W2070147241 hasConceptScore W2070147241C55493867 @default.
- W2070147241 hasConceptScore W2070147241C71924100 @default.
- W2070147241 hasConceptScore W2070147241C86803240 @default.
- W2070147241 hasIssue "2" @default.
- W2070147241 hasLocation W20701472411 @default.
- W2070147241 hasLocation W20701472412 @default.
- W2070147241 hasOpenAccess W2070147241 @default.
- W2070147241 hasPrimaryLocation W20701472411 @default.
- W2070147241 hasRelatedWork W1996846474 @default.
- W2070147241 hasRelatedWork W2018368842 @default.
- W2070147241 hasRelatedWork W2033472167 @default.
- W2070147241 hasRelatedWork W2034583712 @default.
- W2070147241 hasRelatedWork W2052453588 @default.
- W2070147241 hasRelatedWork W2061429094 @default.
- W2070147241 hasRelatedWork W2063619316 @default.
- W2070147241 hasRelatedWork W2126532023 @default.
- W2070147241 hasRelatedWork W2169225653 @default.
- W2070147241 hasRelatedWork W2414846389 @default.
- W2070147241 hasVolume "155" @default.
- W2070147241 isParatext "false" @default.
- W2070147241 isRetracted "false" @default.
- W2070147241 magId "2070147241" @default.
- W2070147241 workType "article" @default.