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- W2070147758 abstract "Purpose To analyse quantitatively retinal microglia signs of activation after two weeks of laser-induced ocular hypertension (OHT) in OHT-eyes and their contralateral eyes Methods Adult albino Swiss mice were assigned to two groups: naïve (n=6) and lasered (n=9). Anti-Iba1 was used in retinal whole-mounts to analyse microglial number and the area covered by each microglial cell (arbor area) Results In naïve, contralateral and OHT-eye microglia were distributed throughout the retina in the photoreceptor layer (PRL), outer plexiform layer (OPL), inner plexiform layer (IPL), nerve-fibre layer (NFL) and ganglion-cell layer (GCL). In comparison with naïve, contralateral eyes and OHT-eyes showed a significant increase in the number of microglial (p<0.05 and p<0.001, respectively) and in the area of the retina occupied by microglial cells in the NFL GCL (p<0.01 and p<0.001 respectively). OHT eyes exhibited significantly higher values than did contralateral eyes for microglial number (p<0.001) and for the area of the retina occupied by microglial cells in the NFL-GCL (p<0.001). In comparison with naïve, the microglial arbor area in the OPL and IPL was decreased in both OHT eyes (p<0.001 in both instances) and in contralateral untreated eyes (p<0.05 and p<0.001, respectively) Conclusion Two weeks of laser-induced OHT induce an increase of microglia number and retraction of processes beyond the GCL both in OHT eyes as well as in contralateral normotensive untreated eyes. Differences between the two groups could help to elucidate glaucoma pathophysiology. (OFTARED Grant RD12/0034/0002 and RD12/0034/0014)" @default.
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- W2070147758 date "2014-08-20" @default.
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- W2070147758 title "Microglia activation in mice retina contralateral to experimental glaucoma: increased cell number and retraction of processes beyond GCL" @default.
- W2070147758 doi "https://doi.org/10.1111/j.1755-3768.2014.s006.x" @default.
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