FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070172358> ?p ?o ?g. }

• W2070172358 endingPage "1338" @default.
• W2070172358 startingPage "1326" @default.
• W2070172358 abstract "Perinatal hypoxia-ischemia may result in long-term neurological deficits. In addition to producing neuron death, HI causes death of neural precursor cells (NPCs) in the developing brain. To characterize the molecular pathways that regulate hypoxia-induced death of NPCs, we treated a mouse neural stem cell line (C17.2 cells) and fibroblastic growth factor II-expanded primary NPCs derived from wild-type or gene-disrupted mice, with oxygen glucose deprivation or the hypoxia mimetics desferrioxamine or cobalt chloride. Neural precursor cells undergoing hypoxia exhibited time- and concentration-dependent caspase-3 activation and cell death, which was significantly reduced by treatment with a broad caspase inhibitor or protein synthesis inhibition. Bax/Bak-deficient NPCs were protected from desferrioxamine-induced death and exhibited minimal caspase-3 activation. Oxygen glucose deprivation or hypoxia-mimetic exposure also resulted in increased hypoxia-inducible factor alpha and bcl-2/adenovirus E1B 19-kd interacting protein 3 (BNIP3) expression. BNIP3 shRNA treatment failed to affect hypoxia-induced caspase-3 activation but inhibited cell death and nuclear translocation of apoptosis-inducing factor, indicating that BNIP3 is an important regulator of caspase-independent NPC death after hypoxia. These studies demonstrate that hypoxia activates both caspase-dependent and -independent NPC death pathways that are critically regulated by multiple Bcl-2 family members." @default.
• W2070172358 created "2016-06-24" @default.
• W2070172358 creator A5003163550 @default.
• W2070172358 creator A5042323656 @default.
• W2070172358 creator A5042737865 @default.
• W2070172358 creator A5055249213 @default.
• W2070172358 creator A5065236748 @default.
• W2070172358 date "2009-12-01" @default.
• W2070172358 modified "2023-10-18" @default.
• W2070172358 title "bcl-2/Adenovirus E1B 19-kd Interacting Protein 3 (BNIP3) Regulates Hypoxia-Induced Neural Precursor Cell Death" @default.
• W2070172358 cites W1580865462 @default.
• W2070172358 cites W1616121322 @default.
• W2070172358 cites W1965827991 @default.
• W2070172358 cites W1972336737 @default.
• W2070172358 cites W1978831014 @default.
• W2070172358 cites W1982500489 @default.
• W2070172358 cites W1987107175 @default.
• W2070172358 cites W1994772532 @default.
• W2070172358 cites W1995417238 @default.
• W2070172358 cites W1997248984 @default.
• W2070172358 cites W1998010000 @default.
• W2070172358 cites W2000624133 @default.
• W2070172358 cites W2005528779 @default.
• W2070172358 cites W2005868568 @default.
• W2070172358 cites W2008597649 @default.
• W2070172358 cites W2012337697 @default.
• W2070172358 cites W2012714617 @default.
• W2070172358 cites W2018149642 @default.
• W2070172358 cites W2020396176 @default.
• W2070172358 cites W2033754704 @default.
• W2070172358 cites W2040031153 @default.
• W2070172358 cites W2046499137 @default.
• W2070172358 cites W2050487189 @default.
• W2070172358 cites W2055538680 @default.
• W2070172358 cites W2066829203 @default.
• W2070172358 cites W2067471739 @default.
• W2070172358 cites W2086540681 @default.
• W2070172358 cites W2095427825 @default.
• W2070172358 cites W2095686972 @default.
• W2070172358 cites W2099926529 @default.
• W2070172358 cites W2111109862 @default.
• W2070172358 cites W2114422046 @default.
• W2070172358 cites W2122065834 @default.
• W2070172358 cites W2144243712 @default.
• W2070172358 cites W2144625075 @default.
• W2070172358 cites W2154978846 @default.
• W2070172358 cites W2158213789 @default.
• W2070172358 cites W2169533924 @default.
• W2070172358 doi "https://doi.org/10.1097/nen.0b013e3181c3b9be" @default.
• W2070172358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2791349" @default.
• W2070172358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19915483" @default.
• W2070172358 hasPublicationYear "2009" @default.
• W2070172358 type Work @default.
• W2070172358 sameAs 2070172358 @default.
• W2070172358 citedByCount "33" @default.
• W2070172358 countsByYear W20701723582012 @default.
• W2070172358 countsByYear W20701723582013 @default.
• W2070172358 countsByYear W20701723582014 @default.
• W2070172358 countsByYear W20701723582015 @default.
• W2070172358 countsByYear W20701723582016 @default.
• W2070172358 countsByYear W20701723582017 @default.
• W2070172358 countsByYear W20701723582018 @default.
• W2070172358 countsByYear W20701723582019 @default.
• W2070172358 countsByYear W20701723582020 @default.
• W2070172358 countsByYear W20701723582021 @default.
• W2070172358 countsByYear W20701723582022 @default.
• W2070172358 crossrefType "journal-article" @default.
• W2070172358 hasAuthorship W2070172358A5003163550 @default.
• W2070172358 hasAuthorship W2070172358A5042323656 @default.
• W2070172358 hasAuthorship W2070172358A5042737865 @default.
• W2070172358 hasAuthorship W2070172358A5055249213 @default.
• W2070172358 hasAuthorship W2070172358A5065236748 @default.
• W2070172358 hasBestOaLocation W20701723581 @default.
• W2070172358 hasConcept C12519072 @default.
• W2070172358 hasConcept C136834591 @default.
• W2070172358 hasConcept C153911025 @default.
• W2070172358 hasConcept C178790620 @default.
• W2070172358 hasConcept C185592680 @default.
• W2070172358 hasConcept C190283241 @default.
• W2070172358 hasConcept C28328180 @default.
• W2070172358 hasConcept C31573885 @default.
• W2070172358 hasConcept C502942594 @default.
• W2070172358 hasConcept C540031477 @default.
• W2070172358 hasConcept C55493867 @default.
• W2070172358 hasConcept C7836513 @default.
• W2070172358 hasConcept C86803240 @default.
• W2070172358 hasConcept C95444343 @default.
• W2070172358 hasConcept C98424977 @default.
• W2070172358 hasConceptScore W2070172358C12519072 @default.
• W2070172358 hasConceptScore W2070172358C136834591 @default.
• W2070172358 hasConceptScore W2070172358C153911025 @default.
• W2070172358 hasConceptScore W2070172358C178790620 @default.
• W2070172358 hasConceptScore W2070172358C185592680 @default.
• W2070172358 hasConceptScore W2070172358C190283241 @default.
• W2070172358 hasConceptScore W2070172358C28328180 @default.
• W2070172358 hasConceptScore W2070172358C31573885 @default.
• W2070172358 hasConceptScore W2070172358C502942594 @default.
• W2070172358 hasConceptScore W2070172358C540031477 @default.

• next