FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070181971> ?p ?o ?g. }

• W2070181971 endingPage "143" @default.
• W2070181971 startingPage "136" @default.
• W2070181971 abstract "A single cell division is governed by the catalytic reactions of cyclins and cyclin-dependent kinases (CDKs). Stem cells are unique in that they can differentiate into tissue-specific cell types (lineage commitment) during cell division (self-renewal). In this study, we analyzed changes in the differentiation potency of adipose tissue-derived stem cells (ADSCs) according to the number of spontaneous cell divisions. We used low passage number (p3) to late passage number (p60) adipose-derived stem cells (ADSCs) as our model system. A preliminary investigation of the typical stem cell phenotypes revealed that CD44 expression decreased remarkably as the passage number of the ADSCs increased. Further examinations revealed that the higher the cell passage number, the lower the cell proliferation capability, differentiation potency, and expression of stem cell transcriptional factors and cell cycle regulators such as cyclins E, A, B, CDK2, and CDK1/CDC2. To verify if the observed changes in differentiation potency according to the number of cell divisions were related to cell cycle regulators, p3 ADSCs were treated with the selective CDK2 and CDK1/CDC2 inhibitor Purvalanol A. Inhibitor treatment of p3 ADSCs induced changes in the morphology, differentiation potency, and pattern of stem cell transcriptional factor expression so that these low passage ADSCs more closely resembled high-passage ADSCs. Collectively, our results indicate that cell cycle regulators control the differentiation potency of ADSCs, and provide insights into the cell biology and differentiation potency of ADSCs according to the number of cell divisions." @default.
• W2070181971 created "2016-06-24" @default.
• W2070181971 creator A5022211470 @default.
• W2070181971 creator A5024324972 @default.
• W2070181971 creator A5025571797 @default.
• W2070181971 creator A5039231309 @default.
• W2070181971 creator A5056337221 @default.
• W2070181971 creator A5081007211 @default.
• W2070181971 creator A5086338684 @default.
• W2070181971 creator A5090001130 @default.
• W2070181971 date "2011-10-01" @default.
• W2070181971 modified "2023-09-26" @default.
• W2070181971 title "Cell cycle regulators are critical for maintaining the differentiation potential and immaturity in adipogenesis of adipose-derived stem cells" @default.
• W2070181971 cites W1977898297 @default.
• W2070181971 cites W1977905227 @default.
• W2070181971 cites W1990419270 @default.
• W2070181971 cites W2001915094 @default.
• W2070181971 cites W2013614359 @default.
• W2070181971 cites W2016931709 @default.
• W2070181971 cites W2017251212 @default.
• W2070181971 cites W2022489847 @default.
• W2070181971 cites W2031586120 @default.
• W2070181971 cites W2052569390 @default.
• W2070181971 cites W2055156816 @default.
• W2070181971 cites W2059259123 @default.
• W2070181971 cites W2065460430 @default.
• W2070181971 cites W2067063540 @default.
• W2070181971 cites W2069810199 @default.
• W2070181971 cites W2074742085 @default.
• W2070181971 cites W2085259589 @default.
• W2070181971 cites W2095085916 @default.
• W2070181971 cites W2097049188 @default.
• W2070181971 cites W2107503723 @default.
• W2070181971 cites W2107575419 @default.
• W2070181971 cites W2115062578 @default.
• W2070181971 cites W2115356458 @default.
• W2070181971 cites W2125928172 @default.
• W2070181971 cites W2142046859 @default.
• W2070181971 cites W2167553081 @default.
• W2070181971 cites W2169792947 @default.
• W2070181971 cites W2173497140 @default.
• W2070181971 cites W2325068802 @default.
• W2070181971 cites W4229982617 @default.
• W2070181971 doi "https://doi.org/10.1016/j.diff.2011.06.002" @default.
• W2070181971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21764208" @default.
• W2070181971 hasPublicationYear "2011" @default.
• W2070181971 type Work @default.
• W2070181971 sameAs 2070181971 @default.
• W2070181971 citedByCount "21" @default.
• W2070181971 countsByYear W20701819712012 @default.
• W2070181971 countsByYear W20701819712013 @default.
• W2070181971 countsByYear W20701819712015 @default.
• W2070181971 countsByYear W20701819712016 @default.
• W2070181971 countsByYear W20701819712017 @default.
• W2070181971 countsByYear W20701819712018 @default.
• W2070181971 countsByYear W20701819712020 @default.
• W2070181971 countsByYear W20701819712021 @default.
• W2070181971 countsByYear W20701819712022 @default.
• W2070181971 countsByYear W20701819712023 @default.
• W2070181971 crossrefType "journal-article" @default.
• W2070181971 hasAuthorship W2070181971A5022211470 @default.
• W2070181971 hasAuthorship W2070181971A5024324972 @default.
• W2070181971 hasAuthorship W2070181971A5025571797 @default.
• W2070181971 hasAuthorship W2070181971A5039231309 @default.
• W2070181971 hasAuthorship W2070181971A5056337221 @default.
• W2070181971 hasAuthorship W2070181971A5081007211 @default.
• W2070181971 hasAuthorship W2070181971A5086338684 @default.
• W2070181971 hasAuthorship W2070181971A5090001130 @default.
• W2070181971 hasConcept C104317684 @default.
• W2070181971 hasConcept C120089663 @default.
• W2070181971 hasConcept C120504264 @default.
• W2070181971 hasConcept C122927707 @default.
• W2070181971 hasConcept C124320809 @default.
• W2070181971 hasConcept C134018914 @default.
• W2070181971 hasConcept C148738053 @default.
• W2070181971 hasConcept C1491633281 @default.
• W2070181971 hasConcept C171089720 @default.
• W2070181971 hasConcept C198826908 @default.
• W2070181971 hasConcept C20875687 @default.
• W2070181971 hasConcept C2780932548 @default.
• W2070181971 hasConcept C28328180 @default.
• W2070181971 hasConcept C29537977 @default.
• W2070181971 hasConcept C54355233 @default.
• W2070181971 hasConcept C86803240 @default.
• W2070181971 hasConcept C95444343 @default.
• W2070181971 hasConceptScore W2070181971C104317684 @default.
• W2070181971 hasConceptScore W2070181971C120089663 @default.
• W2070181971 hasConceptScore W2070181971C120504264 @default.
• W2070181971 hasConceptScore W2070181971C122927707 @default.
• W2070181971 hasConceptScore W2070181971C124320809 @default.
• W2070181971 hasConceptScore W2070181971C134018914 @default.
• W2070181971 hasConceptScore W2070181971C148738053 @default.
• W2070181971 hasConceptScore W2070181971C1491633281 @default.
• W2070181971 hasConceptScore W2070181971C171089720 @default.
• W2070181971 hasConceptScore W2070181971C198826908 @default.
• W2070181971 hasConceptScore W2070181971C20875687 @default.
• W2070181971 hasConceptScore W2070181971C2780932548 @default.
• W2070181971 hasConceptScore W2070181971C28328180 @default.

• next