FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070182333> ?p ?o ?g. }

• W2070182333 endingPage "559" @default.
• W2070182333 startingPage "549" @default.
• W2070182333 abstract "In rat brainstem slices, we investigated the interaction between platelet-activating factor and group I metabotropic glutamate receptors in mediating long-term potentiation within the medial vestibular nuclei. We analysed the N1 field potential wave evoked in the ventral portion of the medial vestibular nuclei by primary vestibular afferent stimulation. The group I metabotropic glutamate receptor antagonist, (R,S)-1-aminoindan-1,5-dicarboxylic acid, prevented long-term potentiation induced by a platelet-activating factor analogue [1-O-hexadecyl-2-O-(methylcarbamyl)-sn-glycero-3-phosphocoline], as well as the full development of potentiation, induced by high-frequency stimulation under the blocking agent for synaptosomal platelet-activating factor receptors (ginkolide B), at drug washout. However, potentiation directly induced by the group I glutamate metabotropic receptor agonist, (R,S)-3,5-dihydroxyphenylglycine, was reduced by ginkolide B. These findings suggest that platelet-activating factor, whether exogenous or released following potentiation induction, exerts its effect through presynaptic group I metabotropic glutamate receptors, mediating the increase of glutamate release. In addition, we found that this mechanism, which led to full potentiation through presynaptic group I metabotropic glutamate receptor activation, was inactivated soon after application of potentiation-inducing stimulus. In fact, the long-lasting block of the platelet-activating factor and metabotropic glutamate receptors prevented the full potentiation development and the induced potentiation progressively declined to null. Moreover, ginkolide B, given when high-frequency-dependent potentiation was established, only reduced it within 5 min after potentiation induction. We conclude that to fully develop vestibular long-term potentiation requires presynaptic events. Platelet-activating factor, released after the activation of postsynaptic mechanisms which induce potentiation, is necessary for coupling postsynaptic and presynaptic phenomena, through the activation of group I metabotropic glutamate receptors, and its action lasts only for a short period. If this coupling does not occur, a full and long-lasting potentiation cannot develop." @default.
• W2070182333 created "2016-06-24" @default.
• W2070182333 creator A5020195488 @default.
• W2070182333 creator A5054013069 @default.
• W2070182333 creator A5072441186 @default.
• W2070182333 creator A5076005340 @default.
• W2070182333 date "1999-09-01" @default.
• W2070182333 modified "2023-10-17" @default.
• W2070182333 title "Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei" @default.
• W2070182333 cites W1567947832 @default.
• W2070182333 cites W1912993735 @default.
• W2070182333 cites W1963963391 @default.
• W2070182333 cites W1969357031 @default.
• W2070182333 cites W1970938545 @default.
• W2070182333 cites W1971229560 @default.
• W2070182333 cites W1974496822 @default.
• W2070182333 cites W1980528531 @default.
• W2070182333 cites W1980803132 @default.
• W2070182333 cites W1985363115 @default.
• W2070182333 cites W1988378335 @default.
• W2070182333 cites W1992349983 @default.
• W2070182333 cites W1995919912 @default.
• W2070182333 cites W1996241414 @default.
• W2070182333 cites W1998961405 @default.
• W2070182333 cites W2000407663 @default.
• W2070182333 cites W2001738424 @default.
• W2070182333 cites W2003058141 @default.
• W2070182333 cites W2005744880 @default.
• W2070182333 cites W2007231856 @default.
• W2070182333 cites W2012831549 @default.
• W2070182333 cites W2014472421 @default.
• W2070182333 cites W2021312182 @default.
• W2070182333 cites W2021720787 @default.
• W2070182333 cites W2023732918 @default.
• W2070182333 cites W2024235867 @default.
• W2070182333 cites W2035245157 @default.
• W2070182333 cites W2036347256 @default.
• W2070182333 cites W2039267613 @default.
• W2070182333 cites W2039498326 @default.
• W2070182333 cites W2040021502 @default.
• W2070182333 cites W2043166209 @default.
• W2070182333 cites W2049317842 @default.
• W2070182333 cites W2049511526 @default.
• W2070182333 cites W2050419480 @default.
• W2070182333 cites W2051473177 @default.
• W2070182333 cites W2054488262 @default.
• W2070182333 cites W2058148599 @default.
• W2070182333 cites W2062058376 @default.
• W2070182333 cites W2063798305 @default.
• W2070182333 cites W2066235362 @default.
• W2070182333 cites W2070094949 @default.
• W2070182333 cites W2085712046 @default.
• W2070182333 cites W2086045560 @default.
• W2070182333 cites W2102268999 @default.
• W2070182333 cites W2157365188 @default.
• W2070182333 cites W2199540394 @default.
• W2070182333 doi "https://doi.org/10.1016/s0306-4522(99)00284-5" @default.
• W2070182333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10579215" @default.
• W2070182333 hasPublicationYear "1999" @default.
• W2070182333 type Work @default.
• W2070182333 sameAs 2070182333 @default.
• W2070182333 citedByCount "21" @default.
• W2070182333 countsByYear W20701823332012 @default.
• W2070182333 crossrefType "journal-article" @default.
• W2070182333 hasAuthorship W2070182333A5020195488 @default.
• W2070182333 hasAuthorship W2070182333A5054013069 @default.
• W2070182333 hasAuthorship W2070182333A5072441186 @default.
• W2070182333 hasAuthorship W2070182333A5076005340 @default.
• W2070182333 hasConcept C160268369 @default.
• W2070182333 hasConcept C169760540 @default.
• W2070182333 hasConcept C170493617 @default.
• W2070182333 hasConcept C185592680 @default.
• W2070182333 hasConcept C207951395 @default.
• W2070182333 hasConcept C25274449 @default.
• W2070182333 hasConcept C26702167 @default.
• W2070182333 hasConcept C41653306 @default.
• W2070182333 hasConcept C49051014 @default.
• W2070182333 hasConcept C55493867 @default.
• W2070182333 hasConcept C61174792 @default.
• W2070182333 hasConcept C73009533 @default.
• W2070182333 hasConcept C86803240 @default.
• W2070182333 hasConcept C98274493 @default.
• W2070182333 hasConceptScore W2070182333C160268369 @default.
• W2070182333 hasConceptScore W2070182333C169760540 @default.
• W2070182333 hasConceptScore W2070182333C170493617 @default.
• W2070182333 hasConceptScore W2070182333C185592680 @default.
• W2070182333 hasConceptScore W2070182333C207951395 @default.
• W2070182333 hasConceptScore W2070182333C25274449 @default.
• W2070182333 hasConceptScore W2070182333C26702167 @default.
• W2070182333 hasConceptScore W2070182333C41653306 @default.
• W2070182333 hasConceptScore W2070182333C49051014 @default.
• W2070182333 hasConceptScore W2070182333C55493867 @default.
• W2070182333 hasConceptScore W2070182333C61174792 @default.
• W2070182333 hasConceptScore W2070182333C73009533 @default.
• W2070182333 hasConceptScore W2070182333C86803240 @default.
• W2070182333 hasConceptScore W2070182333C98274493 @default.
• W2070182333 hasIssue "2" @default.
• W2070182333 hasLocation W20701823331 @default.

• next