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- W2070184849 abstract "Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function." @default.
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- W2070184849 date "2007-07-20" @default.
- W2070184849 modified "2023-10-04" @default.
- W2070184849 title "Patched1 Regulates Hedgehog Signaling at the Primary Cilium" @default.
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- W2070184849 doi "https://doi.org/10.1126/science.1139740" @default.
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