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• W207018641 abstract "Despite their prestige, megatrials are founded upon a methodological error. This is the assumption that randomization of very large numbers of subjects can compensate for deliberately reduced levels of experimental control, but there is no trade-off between size and rigour. Randomized trials are not a 'gold standard' because no method is intrinsically valid-there are good and bad trials. Interpretation of megatrials is always difficult and requires considerable clinical and scientific knowledge. Three fundamental parameters should be considered when evaluating the applicability of a trial to clinical practice: rigour of design; representativeness of the trial population; and homogeneity of the recruited subjects." @default.
• W207018641 created "2016-06-24" @default.
• W207018641 creator A5053582079 @default.
• W207018641 date "1996-07-01" @default.
• W207018641 modified "2023-09-23" @default.
• W207018641 title "Megatrials are based on a methodological mistake." @default.
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