FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070187535> ?p ?o ?g. }

• W2070187535 endingPage "11755" @default.
• W2070187535 startingPage "11748" @default.
• W2070187535 abstract "Studies have linked sex-biased neurodevelopmental disorders, including autism and schizophrenia, with fetal antecedents such as prenatal stress. Further, these outcomes can persist into subsequent generations, raising the possibility that aspects of heritability in these diseases involve epigenetic mechanisms. Utilizing a mouse model in which we previously identified a period in early gestation when stress results in dysmasculinized and stress-sensitive male offspring, we have examined programming effects in second-generation offspring of prenatally stressed (F2-S) or control (F2-C) sires. Examination of gene expression patterns during the perinatal sensitive period, when organizational gonadal hormones establish the sexually dimorphic brain, confirmed dysmasculinization in F2-S males, where genes important in neurodevelopment showed a female-like pattern. Analyses of the epigenomic miRNA environment detected significant reductions in miR-322, miR-574, and miR-873 in the F2-S male brain, levels that were again more similar to those of control females. Increased expression of a common gene target for these three miRNAs, β-glycan, was confirmed in these males. These developmental effects were associated with the transmission of a stress-sensitive phenotype and shortened anogenital distance in adult F2-S males. As confirmation that the miRNA environment is responsive to organizational testosterone, neonatal males administered the aromatase inhibitor formestane exhibited dramatic changes in brain miRNA patterns, suggesting that miRNAs may serve a previously unappreciated role in organizing the sexually dimorphic brain. Overall, these data support the existence of a sensitive period of early gestation when epigenetic programming of the male germline can occur, permitting transmission of specific phenotypes into subsequent generations." @default.
• W2070187535 created "2016-06-24" @default.
• W2070187535 creator A5032882251 @default.
• W2070187535 creator A5051876711 @default.
• W2070187535 date "2011-08-17" @default.
• W2070187535 modified "2023-09-30" @default.
• W2070187535 title "Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage" @default.
• W2070187535 cites W1541257414 @default.
• W2070187535 cites W1968248461 @default.
• W2070187535 cites W1971680163 @default.
• W2070187535 cites W1974503699 @default.
• W2070187535 cites W1986229475 @default.
• W2070187535 cites W1994740828 @default.
• W2070187535 cites W1997033649 @default.
• W2070187535 cites W2004052823 @default.
• W2070187535 cites W2005594217 @default.
• W2070187535 cites W2013096859 @default.
• W2070187535 cites W2015739890 @default.
• W2070187535 cites W2016428032 @default.
• W2070187535 cites W2017936386 @default.
• W2070187535 cites W2022022817 @default.
• W2070187535 cites W2027703088 @default.
• W2070187535 cites W2031541200 @default.
• W2070187535 cites W2031577596 @default.
• W2070187535 cites W2035616108 @default.
• W2070187535 cites W2036509369 @default.
• W2070187535 cites W2046487222 @default.
• W2070187535 cites W2048917877 @default.
• W2070187535 cites W2052687507 @default.
• W2070187535 cites W2055386916 @default.
• W2070187535 cites W2056461989 @default.
• W2070187535 cites W2068242835 @default.
• W2070187535 cites W2070082005 @default.
• W2070187535 cites W2077777662 @default.
• W2070187535 cites W2077798470 @default.
• W2070187535 cites W2079555774 @default.
• W2070187535 cites W2080496806 @default.
• W2070187535 cites W2081040817 @default.
• W2070187535 cites W2084608054 @default.
• W2070187535 cites W2087514104 @default.
• W2070187535 cites W2088161934 @default.
• W2070187535 cites W2089284490 @default.
• W2070187535 cites W2105612107 @default.
• W2070187535 cites W2106670153 @default.
• W2070187535 cites W2111516838 @default.
• W2070187535 cites W2112851246 @default.
• W2070187535 cites W2113719555 @default.
• W2070187535 cites W2114436773 @default.
• W2070187535 cites W2114812859 @default.
• W2070187535 cites W2117837208 @default.
• W2070187535 cites W2120226638 @default.
• W2070187535 cites W2126602202 @default.
• W2070187535 cites W2127456840 @default.
• W2070187535 cites W2130674065 @default.
• W2070187535 cites W2136629435 @default.
• W2070187535 cites W2149154059 @default.
• W2070187535 cites W2150732692 @default.
• W2070187535 cites W2153554004 @default.
• W2070187535 cites W2162109306 @default.
• W2070187535 cites W2162674813 @default.
• W2070187535 cites W2166240615 @default.
• W2070187535 cites W2168538548 @default.
• W2070187535 cites W2168687126 @default.
• W2070187535 cites W4236011771 @default.
• W2070187535 doi "https://doi.org/10.1523/jneurosci.1887-11.2011" @default.
• W2070187535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3164823" @default.
• W2070187535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21849535" @default.
• W2070187535 hasPublicationYear "2011" @default.
• W2070187535 type Work @default.
• W2070187535 sameAs 2070187535 @default.
• W2070187535 citedByCount "285" @default.
• W2070187535 countsByYear W20701875352012 @default.
• W2070187535 countsByYear W20701875352013 @default.
• W2070187535 countsByYear W20701875352014 @default.
• W2070187535 countsByYear W20701875352015 @default.
• W2070187535 countsByYear W20701875352016 @default.
• W2070187535 countsByYear W20701875352017 @default.
• W2070187535 countsByYear W20701875352018 @default.
• W2070187535 countsByYear W20701875352019 @default.
• W2070187535 countsByYear W20701875352020 @default.
• W2070187535 countsByYear W20701875352021 @default.
• W2070187535 countsByYear W20701875352022 @default.
• W2070187535 countsByYear W20701875352023 @default.
• W2070187535 crossrefType "journal-article" @default.
• W2070187535 hasAuthorship W2070187535A5032882251 @default.
• W2070187535 hasAuthorship W2070187535A5051876711 @default.
• W2070187535 hasBestOaLocation W20701875351 @default.
• W2070187535 hasConcept C104317684 @default.
• W2070187535 hasConcept C105083479 @default.
• W2070187535 hasConcept C112672928 @default.
• W2070187535 hasConcept C121912465 @default.
• W2070187535 hasConcept C127716648 @default.
• W2070187535 hasConcept C134018914 @default.
• W2070187535 hasConcept C138496976 @default.
• W2070187535 hasConcept C150194340 @default.
• W2070187535 hasConcept C15744967 @default.
• W2070187535 hasConcept C190727270 @default.
• W2070187535 hasConcept C205778803 @default.

• next