Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070187840> ?p ?o ?g. }
- W2070187840 endingPage "353" @default.
- W2070187840 startingPage "338" @default.
- W2070187840 abstract "In the past few years, a variety of methods have been developed to allow the in vitro evolution of a range of biomolecules including novel and improved biocatalysts (enzymes). These methods for directed evolution differ in the size and characteristics of the gene repertoire, in the way of linking genotype and phenotype, and in the selection approach. Selections for enzymes can be performed indirectly (for binding of a transition-state analogue or mechanism-based inhibitor), and directly using either intramolecular single-turnover selections (e.g. with SELEX) or the normal (intermolecular, multiple turnover) mode of enzymatic reactions. Each of these methods has distinct strengths and weaknesses. The best system (or combinations of systems) to use depends on the specific target for evolution and the evolutionary distance that needs to be crossed." @default.
- W2070187840 created "2016-06-24" @default.
- W2070187840 creator A5002186164 @default.
- W2070187840 creator A5022018631 @default.
- W2070187840 date "2000-08-01" @default.
- W2070187840 modified "2023-10-10" @default.
- W2070187840 title "Man-made enzymes — from design to in vitro compartmentalisation" @default.
- W2070187840 cites W147400386 @default.
- W2070187840 cites W1532707731 @default.
- W2070187840 cites W1556223086 @default.
- W2070187840 cites W1606431180 @default.
- W2070187840 cites W1612553237 @default.
- W2070187840 cites W1807028851 @default.
- W2070187840 cites W190572224 @default.
- W2070187840 cites W1964192335 @default.
- W2070187840 cites W1967558028 @default.
- W2070187840 cites W1968345646 @default.
- W2070187840 cites W1972607828 @default.
- W2070187840 cites W1973626200 @default.
- W2070187840 cites W1975403706 @default.
- W2070187840 cites W1975934174 @default.
- W2070187840 cites W1976112153 @default.
- W2070187840 cites W1976783038 @default.
- W2070187840 cites W1977709085 @default.
- W2070187840 cites W1978992872 @default.
- W2070187840 cites W1981147068 @default.
- W2070187840 cites W1992045296 @default.
- W2070187840 cites W1992179441 @default.
- W2070187840 cites W1995498328 @default.
- W2070187840 cites W1998238795 @default.
- W2070187840 cites W1999033892 @default.
- W2070187840 cites W2003681056 @default.
- W2070187840 cites W2006174330 @default.
- W2070187840 cites W2010537388 @default.
- W2070187840 cites W2012920894 @default.
- W2070187840 cites W2016103121 @default.
- W2070187840 cites W2024383780 @default.
- W2070187840 cites W2028370433 @default.
- W2070187840 cites W2033473419 @default.
- W2070187840 cites W2034561494 @default.
- W2070187840 cites W2037086572 @default.
- W2070187840 cites W2037890761 @default.
- W2070187840 cites W2038479082 @default.
- W2070187840 cites W2044350743 @default.
- W2070187840 cites W2044610162 @default.
- W2070187840 cites W2046338062 @default.
- W2070187840 cites W2048662250 @default.
- W2070187840 cites W2049617243 @default.
- W2070187840 cites W2049624805 @default.
- W2070187840 cites W2051297909 @default.
- W2070187840 cites W2056374924 @default.
- W2070187840 cites W2056892778 @default.
- W2070187840 cites W2060728728 @default.
- W2070187840 cites W2064604291 @default.
- W2070187840 cites W2064648471 @default.
- W2070187840 cites W2066756255 @default.
- W2070187840 cites W2066857567 @default.
- W2070187840 cites W2067863128 @default.
- W2070187840 cites W2068374159 @default.
- W2070187840 cites W2070082076 @default.
- W2070187840 cites W2070495288 @default.
- W2070187840 cites W2073911234 @default.
- W2070187840 cites W2074588113 @default.
- W2070187840 cites W2075266254 @default.
- W2070187840 cites W2078068760 @default.
- W2070187840 cites W2081682162 @default.
- W2070187840 cites W2082177555 @default.
- W2070187840 cites W2086758152 @default.
- W2070187840 cites W2088104795 @default.
- W2070187840 cites W2088185425 @default.
- W2070187840 cites W2090210801 @default.
- W2070187840 cites W2098915542 @default.
- W2070187840 cites W2100554362 @default.
- W2070187840 cites W2105480051 @default.
- W2070187840 cites W2114288212 @default.
- W2070187840 cites W2122689364 @default.
- W2070187840 cites W2134816300 @default.
- W2070187840 cites W2149005864 @default.
- W2070187840 cites W2156972574 @default.
- W2070187840 cites W2167689124 @default.
- W2070187840 cites W226553228 @default.
- W2070187840 cites W2779327081 @default.
- W2070187840 cites W2953232085 @default.
- W2070187840 cites W2953356374 @default.
- W2070187840 cites W4211045835 @default.
- W2070187840 cites W4234644610 @default.
- W2070187840 cites W4236164162 @default.
- W2070187840 doi "https://doi.org/10.1016/s0958-1669(00)00109-9" @default.
- W2070187840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10975453" @default.
- W2070187840 hasPublicationYear "2000" @default.
- W2070187840 type Work @default.
- W2070187840 sameAs 2070187840 @default.
- W2070187840 citedByCount "120" @default.
- W2070187840 countsByYear W20701878402012 @default.
- W2070187840 countsByYear W20701878402013 @default.
- W2070187840 countsByYear W20701878402014 @default.
- W2070187840 countsByYear W20701878402015 @default.
- W2070187840 countsByYear W20701878402016 @default.