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• W2070217525 abstract "Drugs targeted against lipids or their biosyntheses have proved highly effective against fungi. Polyene antibiotics such as amphotericin B bind to sterols (particularly with ergosterol), the complexes aggregate, and then form pores in the organism's membranes, thus abolishing ion gradients. Fluconazole and other related drugs inhibit specific steps in fungal sterol biosynthesis, and are effective against systemic mycoses. Parasites typically scavenge nutrients from their hosts, and metabolize them or utilize them directly for elaborating cellular structures. Thus, membranes can be formed by inserting some host-derived molecules into the bulk phase of lipid bilayers. However, it is believed that some lipids, intimately associated in domains serving important physiological functions (e.g., pumps, enzymes, signal transduction) require parasite lipids having specific three-dimensional configurations. Thus, if host lipids cannot provide the appropriate molecules, the parasite must synthesize at least a low amount of these lipids for those domains. Vital pathogen-specific lipids that are not available from the host have been described as ‘metabolic’ lipids [1, 2] because they enable the organism to function properly and proliferate. These make attractive targets for elimination of the pathogen.Studies on Pneumocystis carinii lipids have been performed on organism preparations for which purity was not rigorously defined by both qualitative and quantitative criteria [3–28]. It became apparent that extensive ground work was required before credible, reproducible and interpretable lipid biochemical data were to be obtained from organisms isolated from infected animal models. The alveolar lining in which P. carinii proliferates is bathed in lung surfactant, which is composed primarily of lipids and lesser amounts of proteins and carbohydrates. The lipids of lung surfactant are characterized by the predominance (about half) of dipalmitoylphosphatidylcholine (disaturated PC). Lung surfactant lipids [3] and proteins [9] bind avidly to P. carinii surfaces which are not removed by washing with …" @default.
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• W2070217525 date "1998-09-01" @default.
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• W2070217525 title "XVII. Lipid metabolism ofPneumocystis: toward the definition of new molecular targets" @default.
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• W2070217525 doi "https://doi.org/10.1111/j.1574-695x.1998.tb01198.x" @default.
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