FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070218639> ?p ?o ?g. }

• W2070218639 endingPage "209" @default.
• W2070218639 startingPage "204" @default.
• W2070218639 abstract "Acute promyelocytic leukemia (APL) has now become the most curable of all subtypes of acute myeloid leukemia. A cure rate of 75–80% can be anticipated with a combination of all-trans retinoic acid (ATRA) and anthracyclines. In Tunisia, the ATRA era began in 1998 with the use, consecutively, of two regimens of a combination of ATRA with anthracycline and cytarabine (APL93), and without cytarabine (LPA99). From 2004, 39 patients with confirmed APL either by t(15;17) or PML/RARA were treated by the PETHEMA LPA 99 trial. The rationale of this protocol by avoiding cytarabine is to reduce death in complete remission (CR) without increasing the incidence of relapse. Thirty-three patients achieved CR (84·6%). The remaining six patients were considered as failure due to early death: three caused by differentiation syndrome (DS) and three died from central nervous system hemorrhage. Baseline blood cell count (WBC) >10 × 109/l (P=0·26) and creatinine >1·4 mg/dl (P=0·42) were not predictive of mortality. DS was observed in 11 patients (30·5%) with a median onset time of 12 days (range: 3–23 days) and median WBC of 29 × 109/L (range: 1·2 × 109–82·7 × 109/l). DS was severe in seven cases, moderate in four, and fatal in three cases. Body mass index ≥30 (P=0·044) and baseline WBC ≥20 × 109/l (P=0·025) are independent predictors of DS. The median follow-up of this study is 36 months. Thirty patients are alive in continuous complete remission; two patients died in CR from septic shock and secondary myelodysplastic syndrome respectively; one patient died 47 months after achieving two relapses. Event free survival from diagnosis was 80% and overall survival was 82%. Our results are quite acceptable and can be improved by reducing mortality rate." @default.
• W2070218639 created "2016-06-24" @default.
• W2070218639 creator A5001276485 @default.
• W2070218639 creator A5006061526 @default.
• W2070218639 creator A5018146438 @default.
• W2070218639 creator A5019341062 @default.
• W2070218639 creator A5020118455 @default.
• W2070218639 creator A5041753374 @default.
• W2070218639 creator A5048571233 @default.
• W2070218639 creator A5051500897 @default.
• W2070218639 creator A5054783478 @default.
• W2070218639 creator A5063236502 @default.
• W2070218639 creator A5065372182 @default.
• W2070218639 creator A5072368202 @default.
• W2070218639 creator A5075314830 @default.
• W2070218639 creator A5078694734 @default.
• W2070218639 creator A5082490388 @default.
• W2070218639 creator A5085830711 @default.
• W2070218639 date "2010-08-01" @default.
• W2070218639 modified "2023-10-18" @default.
• W2070218639 title "Treatment of acute promyelocytic leukemia with PETHEMA LPA 99 protocol: a Tunisian single center experience" @default.
• W2070218639 cites W1577763442 @default.
• W2070218639 cites W1692919389 @default.
• W2070218639 cites W1790757523 @default.
• W2070218639 cites W1931891535 @default.
• W2070218639 cites W1982745688 @default.
• W2070218639 cites W1992842669 @default.
• W2070218639 cites W1997458314 @default.
• W2070218639 cites W2000846352 @default.
• W2070218639 cites W2010077098 @default.
• W2070218639 cites W2021337751 @default.
• W2070218639 cites W2023392000 @default.
• W2070218639 cites W2025338650 @default.
• W2070218639 cites W2039340233 @default.
• W2070218639 cites W2047870782 @default.
• W2070218639 cites W2055722425 @default.
• W2070218639 cites W2079175833 @default.
• W2070218639 cites W2085115829 @default.
• W2070218639 cites W2125012817 @default.
• W2070218639 cites W2128291738 @default.
• W2070218639 cites W2128764431 @default.
• W2070218639 cites W2136772335 @default.
• W2070218639 cites W2138630072 @default.
• W2070218639 cites W2143719308 @default.
• W2070218639 cites W2144635291 @default.
• W2070218639 cites W2165008927 @default.
• W2070218639 cites W2166406669 @default.
• W2070218639 cites W570370693 @default.
• W2070218639 doi "https://doi.org/10.1179/102453309x12583347114176" @default.
• W2070218639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20670478" @default.
• W2070218639 hasPublicationYear "2010" @default.
• W2070218639 type Work @default.
• W2070218639 sameAs 2070218639 @default.
• W2070218639 citedByCount "10" @default.
• W2070218639 countsByYear W20702186392013 @default.
• W2070218639 countsByYear W20702186392017 @default.
• W2070218639 countsByYear W20702186392018 @default.
• W2070218639 countsByYear W20702186392019 @default.
• W2070218639 countsByYear W20702186392020 @default.
• W2070218639 countsByYear W20702186392021 @default.
• W2070218639 countsByYear W20702186392022 @default.
• W2070218639 crossrefType "journal-article" @default.
• W2070218639 hasAuthorship W2070218639A5001276485 @default.
• W2070218639 hasAuthorship W2070218639A5006061526 @default.
• W2070218639 hasAuthorship W2070218639A5018146438 @default.
• W2070218639 hasAuthorship W2070218639A5019341062 @default.
• W2070218639 hasAuthorship W2070218639A5020118455 @default.
• W2070218639 hasAuthorship W2070218639A5041753374 @default.
• W2070218639 hasAuthorship W2070218639A5048571233 @default.
• W2070218639 hasAuthorship W2070218639A5051500897 @default.
• W2070218639 hasAuthorship W2070218639A5054783478 @default.
• W2070218639 hasAuthorship W2070218639A5063236502 @default.
• W2070218639 hasAuthorship W2070218639A5065372182 @default.
• W2070218639 hasAuthorship W2070218639A5072368202 @default.
• W2070218639 hasAuthorship W2070218639A5075314830 @default.
• W2070218639 hasAuthorship W2070218639A5078694734 @default.
• W2070218639 hasAuthorship W2070218639A5082490388 @default.
• W2070218639 hasAuthorship W2070218639A5085830711 @default.
• W2070218639 hasConcept C104317684 @default.
• W2070218639 hasConcept C121608353 @default.
• W2070218639 hasConcept C126322002 @default.
• W2070218639 hasConcept C141071460 @default.
• W2070218639 hasConcept C2776601000 @default.
• W2070218639 hasConcept C2776802502 @default.
• W2070218639 hasConcept C2778041864 @default.
• W2070218639 hasConcept C2778461978 @default.
• W2070218639 hasConcept C2778729363 @default.
• W2070218639 hasConcept C2780073493 @default.
• W2070218639 hasConcept C2780306776 @default.
• W2070218639 hasConcept C2781121885 @default.
• W2070218639 hasConcept C530470458 @default.
• W2070218639 hasConcept C55493867 @default.
• W2070218639 hasConcept C71924100 @default.
• W2070218639 hasConcept C86803240 @default.
• W2070218639 hasConcept C90924648 @default.
• W2070218639 hasConceptScore W2070218639C104317684 @default.
• W2070218639 hasConceptScore W2070218639C121608353 @default.
• W2070218639 hasConceptScore W2070218639C126322002 @default.

• next